Patents by Inventor Christine E. Schmidt

Christine E. Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11058802
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: July 13, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Publication number: 20210187070
    Abstract: Disclosed herein is a method of treating a subject for a disease, disorder, or condition that involves administering to the subject a composition comprising a secretome derived from electrically stimulated cells. Also disclosed herein is an enhanced secretome produced by a process comprising collecting cells from a subject, culturing the cells in a serum free medium for at least 1 day while stimulating the cells with electric pulses, and collecting the secretome produced by the electrically-stimulated cells. Also disclosed herein is a pharmaceutical composition comprising an enhanced secretome derived from electrically stimulated cells contained within a biocompatible hydrogel in an amount effective to treat a disease or disorder.
    Type: Application
    Filed: August 1, 2019
    Publication date: June 24, 2021
    Inventors: Christine E. Schmidt, Sahba Mobini
  • Publication number: 20210178024
    Abstract: The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.
    Type: Application
    Filed: January 29, 2021
    Publication date: June 17, 2021
    Inventors: CARLOS RINALDI, CHRISTINE E. SCHMIDT, CHRISTOPHER LACKO, ZIN Z. KHAING, ANDREW GARCIA
  • Patent number: 11007278
    Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: May 18, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Hardy, Christine E. Schmidt
  • Publication number: 20210069388
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Application
    Filed: November 19, 2020
    Publication date: March 11, 2021
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Publication number: 20210046125
    Abstract: Described herein are methods of producing decellularized tissue hydrogels. In some aspects, the decellularized tissue hydrogels can contain one or more extracellular matrix proteins. Also described herein are methods of making the decellularized tissue hydrogels. Also described herein are methods of using the decellularized tissue hydrogels. In some aspects, the decellularized tissue hydrogels or a pre-gel solution can be administered to a subject.
    Type: Application
    Filed: February 21, 2019
    Publication date: February 18, 2021
    Inventors: Nikunj Agrawal, Jonathan Griffin, Christine E. Schmidt, Michaela W. McCrary, Deanna Bousalis, Young Hye Song
  • Patent number: 10918767
    Abstract: The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: February 16, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Carlos Rinaldi, Christine E. Schmidt, Christopher Lacko, Zin Z. Khaing, Andrew Garcia
  • Patent number: 10898609
    Abstract: Provided herein are methods of producing an acellular tissue product wherein the method can include the step of inducing apoptosis and washing the tissue after induction of apoptosis with a tonic solution. Also provided herein are acellular tissue products produced by the methods provided herein and methods of administering the acellular tissue products to a subject in need thereof.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: January 26, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Christine E. Schmidt, Rebecca Ann Wachs, Robert Chase Cornelison
  • Patent number: 10850011
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: December 1, 2020
    Assignee: Board of Regents, The University of Texas
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Publication number: 20200316220
    Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
    Type: Application
    Filed: April 9, 2020
    Publication date: October 8, 2020
    Inventors: John HARDY, Christine E. SCHMIDT
  • Publication number: 20200215317
    Abstract: Wireless and non-wireless drug delivery integrated circuits, systems, and methods of delivering therapeutic pharmaceutical compounds are provided. The system can include a control module, a wireless drug delivery integrated circuit, a first electrode and a second electrode that are both attached to the wireless drug delivery integrated circuit, an electroactive polymer, and a pharmaceutical compound. The electroactive polymer and the pharmaceutical compound can be formed as films on one of the electrodes and, when placed in a solution, a voltage potential can be applied across the electrodes causing the pharmaceutical compound to be released into the solution.
    Type: Application
    Filed: February 17, 2017
    Publication date: July 9, 2020
    Inventors: Byul Hur, John Hardy, William R. Eisenstadt, Christine E. Schmidt
  • Publication number: 20200181570
    Abstract: A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue.
    Type: Application
    Filed: February 12, 2020
    Publication date: June 11, 2020
    Inventors: John HARDY, Christine E. SCHMIDT
  • Patent number: 10653798
    Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 19, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Hardy, Christine E. Schmidt
  • Patent number: 10597636
    Abstract: A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: March 24, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Hardy, Christine E. Schmidt
  • Publication number: 20200054875
    Abstract: Tissue-engineered nerve scaffolds, articles for up-selecting desired cell proliferation and down-selecting undesired cell proliferation, and methods of manufacturing the same are provided. The tissue-engineered nerve scaffold includes a hydrogel having a surface. The surface has a topography including a micropattern defined by a plurality of spaced features attached to or projected into the hydrogel. The micropattern facilitates attachment and alignment of neural cells and reduces attachment and alignment of cells associated with scar-tissue formation and encapsulation.
    Type: Application
    Filed: February 13, 2018
    Publication date: February 20, 2020
    Inventors: Sahba MOBINI, Christine E. SCHMIDT, Anthony B. BRENNAN, Cary A. KULIASHA, Jack JUDY
  • Publication number: 20190314558
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Application
    Filed: May 1, 2019
    Publication date: October 17, 2019
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Publication number: 20190216987
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Application
    Filed: March 20, 2019
    Publication date: July 18, 2019
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Patent number: 10314950
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: June 11, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Patent number: 10272184
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: April 30, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Publication number: 20180338765
    Abstract: Tissue-engineered electronic peripheral nerve interface (TEENI) devices, methods of using TEENI devices, and systems using TEENI devices are provided. In particular, TEENI devices include a support member having a length, at least one thread set comprising a plurality thread set arms having a plurality of electronic leads running through the thread set arms and being fully encapsulated within the support member, and a plurality of electrodes fixed to the plurality of thread set arms.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventors: Jack JUDY, Christine E. SCHMIDT, Kevin OTTO, Carlos RINALDI, Cary A. KULIASHA