Patents by Inventor Christine E. Schmidt

Christine E. Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180338765
    Abstract: Tissue-engineered electronic peripheral nerve interface (TEENI) devices, methods of using TEENI devices, and systems using TEENI devices are provided. In particular, TEENI devices include a support member having a length, at least one thread set comprising a plurality thread set arms having a plurality of electronic leads running through the thread set arms and being fully encapsulated within the support member, and a plurality of electrodes fixed to the plurality of thread set arms.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventors: Jack JUDY, Christine E. SCHMIDT, Kevin OTTO, Carlos RINALDI, Cary A. KULIASHA
  • Publication number: 20180207318
    Abstract: Provided herein are methods of producing an acellular tissue product wherein the method can include the step of inducing apoptosis and washing the tissue after induction of apoptosis with a tonic solution. Also provided herein are acellular tissue products produced by the methods provided herein and methods of administering the acellular tissue products to a subject in need thereof.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 26, 2018
    Inventors: CHRISTINE E. SCHMIDT, REBECCA ANN WACHS, ROBERT CHASE CORNELISON
  • Publication number: 20180140718
    Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
    Type: Application
    Filed: June 1, 2016
    Publication date: May 24, 2018
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: JOHN HARDY, CHRISTINE E. SCHMIDT
  • Publication number: 20180133372
    Abstract: The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.
    Type: Application
    Filed: May 11, 2016
    Publication date: May 17, 2018
    Inventors: CARLOS RINALDI, CHRISTINE E. SCHMIDT, CHRISTOPHER LACKO, ZIN Z. KHAING, ANDREW GARCIA
  • Publication number: 20170312397
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Application
    Filed: May 16, 2017
    Publication date: November 2, 2017
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Patent number: 9783637
    Abstract: A biodegradable electroactive material can be doped with a drug and the drug can be delivered to a living subject by stimulating the material with an electrical potential. The material (in this case a polymer) has an electrochemically responsive oligoaniline block terminated with a carboxylic acid moiety and is linked to an alcohol-terminated diol by an ester bond. Advantageously, the diol is PEG-400, PEG-2000, PCL-530, or PCL-2000.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: October 10, 2017
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Hardy, Christine E. Schmidt
  • Publication number: 20170252491
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Application
    Filed: May 17, 2017
    Publication date: September 7, 2017
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Patent number: 9662424
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: May 30, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Patent number: 9656001
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 23, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Patent number: 9597429
    Abstract: The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more sulfobetaines and an anionic surface-active detergent and washing the tissue replacement in serial solutions of the buffered salt to remove excess detergent. The natural, cell-free tissue replacement may be a nerve graft that supports axonal regeneration, guides the axons toward the distal nerve end and/or is immunologically tolerated. Other forms of the invention are a composition and kit prepared by the method of making a native, cell-free tissue replacement. The present invention may be modified for use in diagnostic, therapeutic, and prophylactic applications.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: March 21, 2017
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Christine E. Schmidt, Terry Hudson
  • Publication number: 20160083692
    Abstract: A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue.
    Type: Application
    Filed: September 19, 2014
    Publication date: March 24, 2016
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: John Hardy, Christine E. Schmidt
  • Publication number: 20160015866
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Application
    Filed: July 20, 2015
    Publication date: January 21, 2016
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Publication number: 20150320915
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Application
    Filed: December 11, 2013
    Publication date: November 12, 2015
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Publication number: 20150265712
    Abstract: A biodegradable electroactive material can be doped with a drug and the drug can be delivered to a living subject by stimulating the material with an electrical potential. The material (in this case a polymer) has an electrochemically responsive oligoaniline block terminated with a carboxylic acid moiety and is linked to an alcohol-terminated diol by an ester bond. Advantageously, the diol is PEG-400, PEG-2000, PCL-530, or PCL-2000.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 24, 2015
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: John Hardy, Christine E. Schmidt
  • Patent number: 9095558
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: August 4, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Patent number: 8946194
    Abstract: The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: February 3, 2015
    Assignee: Board of Regents, University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Publication number: 20140248325
    Abstract: The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more sulfobetaines and an anionic surface-active detergent and washing the tissue replacement in serial solutions of the buffered salt to remove excess detergent. The natural, cell-free tissue replacement may be a nerve graft that supports axonal regeneration, guides the axons toward the distal nerve end and/or is immunologically tolerated. Other forms of the invention are a composition and kit prepared by the method of making a native, cell-free tissue replacement. The present invention may be modified for use in diagnostic, therapeutic, and prophylactic applications.
    Type: Application
    Filed: May 9, 2014
    Publication date: September 4, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventors: Christine E. Schmidt, Terry Hudson
  • Patent number: 8668863
    Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: March 11, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Scott Zawko, Christine E. Schmidt
  • Publication number: 20120088832
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Applicant: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt, Daniel Peterson
  • Publication number: 20120088735
    Abstract: The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Applicant: The Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt