Patents by Inventor Christof Fattinger

Christof Fattinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10684227
    Abstract: A method for the detection of binding affinities comprises providing a device having a planar waveguide (2) arranged on a substrate (3) and an optical coupler (4). Coherent light (1) of a predetermined wavelength is coupled into the planar waveguide (2) such that the coherent light propagates along the planar waveguide (2), with an evanescent field (6) of the coherent light propagating along an outer surface (5) of the planar waveguide (2). Target samples (8) attached to binding sites (7) are arranged along a plurality of predetermined lines (9) on the outer surface (5) of the planar waveguide (2). At a predetermined detection location, light of the evanescent field which is scattered by target samples (8) bound to binding sites (7) arranged along the predetermined lines (9) is detected.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: June 16, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Christof Fattinger
  • Publication number: 20180364174
    Abstract: A method for the detection of binding affinities comprises providing a device having a planar waveguide (2) arranged on a substrate (3) and an optical coupler (4). Coherent light (1) of a predetermined wavelength is coupled into the planar waveguide (2) such that the coherent light propagates along the planar waveguide (2), with an evanescent field (6) of the coherent light propagating along an outer surface (5) of the planar waveguide (2). Target samples (8) attached to binding sites (7) are arranged along a plurality of predetermined lines (9) on the outer surface (5) of the planar waveguide (2). At a predetermined detection location, light of the evanescent field which is scattered by target samples (8) bound to binding sites (7) arranged along the predetermined lines (9) is detected.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 20, 2018
    Inventor: Christof Fattinger
  • Patent number: 10156524
    Abstract: A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: December 18, 2018
    Assignee: Hoffmann-La-Roche Inc.
    Inventor: Christof Fattinger
  • Patent number: 10060917
    Abstract: A device (1) for use in the detection of binding affinities comprises a planar waveguide (2) arranged on a substrate (22). The waveguide (2) has an outer surface (21) and a plurality of incoupling lines (31) for coupling a beam of coherent light into the waveguide (2) such that a parallel beam of coherent light (62) propagates along the waveguide (2). The incoupling lines (31) are curved and have an increasing distance between adjacent incoupling lines (31). A divergent beam of coherent light (61) of a predetermined wavelength is coupled into the waveguide (2) such that it propagates along the waveguide (2). A plurality of binding sites (51) is attached to the outer surface (21) along at least one further plurality of diffraction lines arranged in an outcoupling section of the waveguide (2). These diffraction lines comprise a plurality of curved outcoupling lines (41) having a decreasing distance between adjacent outcoupling lines.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: August 28, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Christof Fattinger
  • Patent number: 10006866
    Abstract: A device for use in the detection of binding affinities comprises a planar waveguide (2) arranged on a substrate (3), and an optical coupler (4) for coupling coherent light (1) of a predetermined wavelength into the planar waveguide. The coherent light propagates through the planar waveguide (2) with an evanescent field (6) propagating along an outer surface (5) of the planar waveguide. The outer surface (5) of the planar waveguide comprises binding sites (7) thereon capable of binding target samples (8) to the binding sites (7) such that light of the evanescent field (6) is scattered by target samples (8) bound to the binding sites (7). The binding sites (7) are arranged along a plurality of predetermined lines (9) which are arranged such that the scattered light constructively interferes at a predetermined detection location with a difference in optical path length which is an integer multiple of the predetermined wavelength.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: June 26, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Christof Fattinger
  • Patent number: 9636680
    Abstract: Sample handling system for handling samples contained in tubes (4), each tube (4) having a hollow body, a closed bottom and an open top for accessing the sample contained in the tube (4). The system comprises a micro-plate (1) comprising at least one grid insert (2) having a plurality of compartments. Each compartment comprises one or more side walls laterally confining a through-hole for receiving a said tube (4). The through-hole has a top opening and a bottom opening and extends between the top opening and the bottom opening. A frame (3) to which the at least one separate grid insert (2) is to be attached to form the micro-plate (1). The frame (3) laterally confines a through-opening which is dimensioned to allow for accessing each compartment (21) of the attached at least one grid insert (2) from above and from below. This allows for moving such tube (4) into and out of each compartment (21) through each of the top opening (202) and the bottom opening (203) of the through-hole (201).
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: May 2, 2017
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Christof Fattinger, Tom Kissling, Thomas Zumstein
  • Patent number: 9446408
    Abstract: A system for dispensing a sample into a buffer liquid includes a pressure chamber having pressure supply means for generating an overpressure within the pressure chamber. An inlet capillary supplies a buffer liquid to an outlet end arranged in the pressure chamber, and an outlet capillary discharges the buffer liquid from the pressure chamber. The outlet capillary has an inlet end in the pressure chamber facing the outlet end of the inlet capillary to form a capillary gap. A dispenser having a dispensing end is in the pressure chamber at the capillary gap to allow the sample at the dispensing end to be dispensed into the buffer liquid entering the outlet capillary inlet end. The pressure chamber includes a sample port that allows the dispenser to be moved into and out of the pressure chamber.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: September 20, 2016
    Assignee: F. Hoffman-La Roche AG
    Inventors: Peter Berndt, Christof Fattinger, Roger Steiner
  • Patent number: 9405069
    Abstract: According to the invention there is provided a method for preparing the outer surface (11) of the planar waveguide (1) for binding target samples along the plurality of predetermined lines (4). The method comprises the following steps. Providing a planar waveguide (1) with an outer surface (11) adapted for attachment of a head group (21) of a linker molecule (2) to the outer surface (11). Sequentially applying at least one plurality of linker molecules (2, 5) to the outer surface (11). Each plurality of the at least one plurality of linker molecules (2, 5) assembles to form an individual layer of linker molecules (2, 5) with individual layers formed one above the other starting from the outer surface (11) of the planar waveguide (1). Each linker molecule (2, 5) comprises a functional group (22, 52) and the head group (21, 51) which is capable of attaching to the outer surface (11) of the planar waveguide (1) or to the functional groups (22) of the preceding layer of linker molecules (2).
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: August 2, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventor: Christof Fattinger
  • Publication number: 20160161477
    Abstract: A device (1) for use in the detection of binding affinities comprises a planar waveguide (2) arranged on a substrate (22). The waveguide (2) has an outer surface (21) and a plurality of incoupling lines (31) for coupling a beam of coherent light into the waveguide (2) such that a parallel beam of coherent light (62) propagates along the waveguide (2). The incoupling lines (31) are curved and have an increasing distance between adjacent incoupling lines (31). A divergent beam of coherent light (61) of a predetermined wavelength is coupled into the waveguide (2) such that it propagates along the waveguide (2). A plurality of binding sites (51) is attached to the outer surface (21) along at least one further plurality of diffraction lines arranged in an outcoupling section of the waveguide (2). These diffraction lines comprise a plurality of curved outcoupling lines (41) having a decreasing distance between adjacent outcoupling lines.
    Type: Application
    Filed: July 11, 2014
    Publication date: June 9, 2016
    Inventor: Christof Fattinger
  • Publication number: 20160139115
    Abstract: A device (1) for use in the detection of binding affinities comprises a substrate (2) devoid of a waveguide. The substrate (2) has a planar surface (21) having arranged thereon a plurality of binding sites (31) capable of binding with a target molecule (32). The binding sites (31) are arranged along a plurality of adjacently arranged curved lines (4). The lines are spaced from one another by a distance to in operation cause a beam of coherent light (51) of a predetermined wavelength incident on the binding sites (31) with the bound target molecule (32) to be diffracted in a manner such that diffracted portions (61) interfere at a predetermined detection location (62) with a difference in optical path length which is a multiple integer of the predetermined wavelength of the coherent light. The device further comprises a beam stop (7) arranged to prevent propagation of non-diffracted portions (63) of the incident beam of coherent light (51) to the detection location (62).
    Type: Application
    Filed: July 14, 2014
    Publication date: May 19, 2016
    Inventor: Christof Fattinger
  • Patent number: 9267933
    Abstract: A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: February 23, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christof Fattinger, Patrick Iaiza, Tom Kissling, Dieter Voegelin, Thomas Zumstein, Claudia Mcginnis
  • Patent number: 9201084
    Abstract: A robotic microplate storage system includes a freezer room having freezing units and a first robot for moving and removing microplates into and out of the freezing unit. The first robot can also transfer microplates to a processing station, where the microplates are stored in a microplate recipient within the freezing unit. The storage system may also include at least one processing room which is thermally separated from the freezer room. Each processing room may include a processing station having a tube transfer module and a second robot for moving the microplates between the microplate recipients and the tube transfer module. The first robot may be designed such that it is only capable of removing a microplate recipient from and moving it into a freezing unit as well as transferring it from a freezing unit to a processing station or vice versa.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: December 1, 2015
    Assignee: F. HOFFMAN-LA ROCHE AG
    Inventors: Christof Fattinger, Remo Anton Hochstrasser, Dieter Voegelin, Thomas Zumstein
  • Publication number: 20150338579
    Abstract: According to the invention there is provided a method for preparing the outer surface (11) of the planar waveguide (1) for binding target samples along the plurality of predetermined lines (4). The method comprises the following steps. Providing a planar waveguide (1) with an outer surface (11) adapted for attachment of a head group (21) of a linker molecule (2) to the outer surface (11). Sequentially applying at least one plurality of linker molecules (2, 5) to the outer surface (11). Each plurality of the at least one plurality of linker molecules (2, 5) assembles to form an individual layer of linker molecules (2, 5) with individual layers formed one above the other starting from the outer surface (11) of the planar waveguide (1). Each linker molecule (2, 5) comprises a functional group (22, 52) and the head group (21, 51) which is capable of attaching to the outer surface (11) of the planar waveguide (1) or to the functional groups (22) of the preceding layer of linker molecules (2).
    Type: Application
    Filed: January 17, 2014
    Publication date: November 26, 2015
    Inventor: Christof Fattinger
  • Publication number: 20150276612
    Abstract: A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines.
    Type: Application
    Filed: December 3, 2013
    Publication date: October 1, 2015
    Inventor: Christof Fattinger
  • Publication number: 20150238966
    Abstract: A system for dispensing a sample (5) into a buffer liquid comprises a pressure chamber (1) having pressure supply means for generating an overpressure within the pressure chamber. An inlet capillary (2) is provided for supplying a buffer liquid (9) to an outlet end (6) arranged in the pressure chamber. Also, an outlet capillary (3) is provided for discharging buffer liquid and/or sample from the pressure chamber. The outlet capillary (3) has an inlet end (7) arranged in the pressure chamber (1) facing the outlet end (6) of the inlet capillary (2) to form a capillary gap (8). A dispenser (4) having a dispensing end (10) is arranged in the pressure chamber (1) at the capillary gap (8) to allow the sample (5) at the dispensing end (10) to be dispensed from the dispensing end (10) into the buffer liquid entering the inlet end (7) of the outlet capillary (3).
    Type: Application
    Filed: September 6, 2013
    Publication date: August 27, 2015
    Inventors: Peter Berndt, Christof Fattinger, Roger Steiner
  • Publication number: 20150017078
    Abstract: Sample handling system for handling samples contained in tubes (4), each tube (4) having a hollow body, a closed bottom and an open top for accessing the sample contained in the tube (4). The system comprises a micro-plate (1) comprising at least one grid insert (2) having a plurality of compartments. Each compartment comprises one or more side walls laterally confining a through-hole for receiving a said tube (4). The through-hole has a top opening and a bottom opening and extends between the top opening and the bottom opening. A frame (3) to which the at least one separate grid insert (2) is to be attached to form the micro-plate (1). The frame (3) laterally confines a through-opening which is dimensioned to allow for accessing each compartment (21) of the attached at least one grid insert (2) from above and from below. This allows for moving such tube (4) into and out of each compartment (21) through each of the top opening (202) and the bottom opening (203) of the through-hole (201).
    Type: Application
    Filed: February 1, 2013
    Publication date: January 15, 2015
    Applicant: F. HOFFMANN-LA ROCHE AG
    Inventors: Christof Fattinger, Tom Kissling, Thomas Zumstein
  • Publication number: 20140363901
    Abstract: A device for use in the detection of binding affinities comprises a planar waveguide (2) arranged on a substrate (3), and an optical coupler (4) for coupling coherent light (1) of a predetermined wavelength into the planar waveguide. The coherent light propagates through the planar waveguide (2) with an evanescent field (6) propagating along an outer surface (5) of the planar waveguide. The outer surface (5) of the planar waveguide comprises binding sites (7) thereon capable of binding target samples (8) to the binding sites (7) such that light of the evanescent field (6) is scattered by target samples (8) bound to the binding sites (7). The binding sites (7) are arranged along a plurality of predetermined lines (9) which are arranged such that the scattered light constructively interferes at a predetermined detection location with a difference in optical path length which is an integer multiple of the predetermined wavelength.
    Type: Application
    Filed: January 17, 2013
    Publication date: December 11, 2014
    Applicant: Hoffmann-La Roche Inc.
    Inventor: Christof Fattinger
  • Publication number: 20140106395
    Abstract: A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).
    Type: Application
    Filed: March 2, 2012
    Publication date: April 17, 2014
    Inventors: Christof Fattinger, Patrick Iaiza, Tom Kissling, Dieter Voegelin, Thomas Zumstein, Claudia Mcginnis
  • Publication number: 20120276575
    Abstract: A unit (10) for the preparation of cells contained in a liquid comprises a storage chamber (20) configured to store the liquid containing the cells and to release the stored liquid via an exit opening (22) upon the application of a predetermined external force, in particular a centrifugal force. A passage (30) adjacently arranged to the exit opening (22) has a cross-section larger than that of the exit opening (22). The wall at the transition from the exit opening (22) to the passage (30) forms an edge (32). The unit further comprises an observation member (50) for receiving the released liquid and an absorbing means (40) arranged adjacent to the observation member (50) between the passage (30) and the observation member (50). The absorbing means (40) has an aperture (42) allowing the released liquid to travel onto the observation member (50), and removes the liquid so as to leave the cells on the observation member (50) for observation.
    Type: Application
    Filed: December 20, 2010
    Publication date: November 1, 2012
    Inventors: Christof Fattinger, Rene Rietmann, Dieter Voegelin
  • Publication number: 20100086440
    Abstract: In some embodiments of the present disclosure, a robotic storage system for storing microplates carrying a plurality of sample tubes is provided and may comprise a freezer room having a plurality of freezing units and a first robot being capable of removing a microplate from and moving a microplate into a freezing unit. The first robot may be further capable of transferring the microplate to a processing station, where the microplates are stored in the freezing units such that a plurality of microplates are arranged one above the other in a microplate recipient. The robotic storage system may also include at least one processing room and means for thermally separating the processing room from the freezer room. Each processing room may include a processing station having at least one tube transfer module as well as a second robot for moving the microplates between the microplate recipients and the at least one tube transfer module.
    Type: Application
    Filed: September 30, 2009
    Publication date: April 8, 2010
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Christof Fattinger, Remo Anton Hochstrasser, Dieter Voegelin, Thomas Zumstein