Abstract: A method of analysing a sample containing biological cells to detect the presence of a plurality of biomolecules, or a plurality of sequences within a biomolecule or biomolecules. The sample is lysed and introduced in the chamber of a cartridge comprising multiple chambers and an analysis unit. The sample is displaced to the analysis unit where isothermal or thermo-cycled pre-amplification is performed on the sample. Pre-amplification is followed by isothermal or thermo-cycled amplification to identify the presence of said plurality of biomolecules or sequences, or of a plurality of second biomolecules or sequences derived from the first mentioned plurality of biomolecules or sequences in a short time frame.

Abstract: A method of analysing a sample comprising nucleic acid. The method includes introducing the sample into a discrete container that is prefilled with a lysis buffer. Agitating the container to assist with lysing to release nucleic acid. Extracting a lysed sample from the container and introducing the lysed sample into a sample chamber of a disposable cartridge. Mixing the lysed sample with a dilution buffer in the sample chamber to obtain a first mixture. Fluidly connecting the sample chamber to a mixing chamber. “Displacing the first mixture from the sample chamber to the mixing chamber. Fluidly connecting the mixing chamber to a mastermix chamber containing a mastermix. Displacing the first mixture to obtain a second mixture.” Displacing the second mixture from the mastermix chamber to an analysis unit. Operating the analysis unit to identify the nucleic acid or other nucleic acids derived from the nucleic acid.

Abstract: A method of allowing a user to scan products and obtain product recommendations based on the user's personal biological/genetic data, using a cartridge to perform a test on the data in conjunction with a test control system into which the cartridge is plugged. A user account is created and is associated with a cartridge ID that is read from the cartridge by the tablet and is also read using the wearable user device and passed via the test control system to a server when the wearable user device is coupled to the test control system. The test control system communicates test results to the server which analyses the test results to generate analysis results. The analysis results are then downloaded to the wearable user device via the test control system or some other channel. Product codes are also downloaded and stored to the wearable user device.

Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.

Abstract: A method of adaptively determining one or more compensation factors in a closed-loop insulin delivery system comprising a continuous glucose level sensor, an insulin pump, and an insulin reservoir, where the system determines an insulin meal bolus taking into account an estimated amount of carbohydrates to be ingested, CHO, a difference between a currently sensed glucose level, G, and a glucose set point, Gsp, and at least one compensation factor, ICR.

Abstract: A disposable cartridge comprising a sample receiving chamber for receiving a human or animal sample and an analysis unit (AU) having a multiplicity of reaction sites for providing a detectable indication of the presence in said sample of (a) one or more viral or bacterial nucleic acid sequences; and (b) one or more defined single nucleotide polymorphisms in the human or animal genome.

Abstract: A computer-implemented method of comparing one or more genetic traits of two users. Each user has a wearable device storing data indicative of the one or more genetic traits, the data having been obtained by an analysis of a biological sample provided by the user. The method comprises: transmitting the data indicative of the one or more genetic traits from a first of the wearable devices to a first computer device using a short-range wireless data connection; transmitting the data from the first computer device to a second computer device over a data network; transmitting the data from the second computer device to a second of the wearable devices over a short-range wireless data connection; and comparing the data from the first wearable device with the data stored on the second wearable device to determine whether there is a match between the users' one or more genetic traits.

Abstract: A computer implemented method is for providing user devices with alternative content. The method includes: defining a plurality of search parameters; crawling the world wide web or selected parts thereof, or searching predefined web sites, to identify content matching one or more of said search parameters; generating image triggers by extracting the identified content or generating digital fingerprints indicative of the identified content; storing the image triggers in a database, together with respective alternative content or alternative content identifiers; receiving an image captured from a printed or displayed medium at an end user device; searching the captured image to identify a presence of at least one of the image triggers in the captured image; and causing alternative content corresponding to the at least one of the image triggers to be displayed or presented at the end user device, or a respective other device associated with the end user device.

Abstract: A computer-implemented method of comparing one or more genetic traits of two users. Each user has a wearable device storing data indicative of the one or more genetic traits, the data having been obtained by an analysis of a biological sample provided by the user. The method comprises: transmitting the data indicative of the one or more genetic traits from a first of the wearable devices to a first computer device using a short-range wireless data connection; transmitting the data from the first computer device to a second computer device over a data network; transmitting the data from the second computer device to a second of the wearable devices over a short-range wireless data connection; and comparing the data from the first wearable device with the data stored on the second wearable device to determine whether there is a match between the users' one or more genetic traits.

Abstract: The present invention relates to the use of pooled samples to optimise the efficiency and utility of a rapid, lab-free point-of-care test. It is applicable in particular, though not necessarily, to tests for SARS-CoV-2.

Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.

Abstract: A method of allowing a user to scan products and obtain product recommendations based on the user's personal biological/genetic data, using a cartridge to perform a test on the data in conjunction with a test control system into which the cartridge is plugged. A user account is created and is associated with a cartridge ID that is read from the cartridge by the tablet and is also read using the wearable user device and passed via the test control system to a server when the wearable user device is coupled to the test control system. The test control system communicates test results to the server which analyses the test results to generate analysis results. The analysis results are then downloaded to the wearable user device via the test control system or some other channel. Product codes are also downloaded and stored to the wearable user device.

Abstract: The present invention relates to the use of pooled samples to optimise the efficiency and utility of a rapid, lab-free point-of-care test. It is applicable in particular, though not necessarily, to tests for SARS-CoV-2.

Abstract: A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.

Abstract: A computer-implemented method of comparing one or more genetic traits of two users. Each user has a wearable device storing data indicative of the one or more genetic traits, the data having been obtained by an analysis of a biological sample provided by the user. The method comprises: transmitting the data indicative of the one or more genetic traits from a first of the wearable devices to a first computer device using a short-range wireless data connection; transmitting the data from the first computer device to a second computer device over a data network; transmitting the data from the second computer device to a second of the wearable devices over a short-range wireless data connection; and comparing the data from the first wearable device with the data stored on the second wearable device to determine whether there is a match between the users' one or more genetic traits.

Abstract: A wrist-worn device comprises a band or strap for attaching the device to a wearer's wrist; a product code reader comprising at least one optical component; a sensor; and a processor. The sensor is configured in use to detect rotation of the device indicative of a rotation of the device around a longitudinal axis of the wearer's wrist. The processor is coupled to the sensor and to the product code reader and is configured in use to activate the optical component, or place the device in a state in which a predefined subsequent action or actions can activate the optical component, when the sensor detects a rotation of the device over at least a predefined angle.

Abstract: A wearable device comprising a memory storing a database of product codes and associated product recommendations derived from personalised biological information, a product code reader for reading a product code or data from a product, and a processor for using a read product code or read data to perform a look-up in the database to obtain a product recommendation for the associated product. The wearable device further comprises an indicator for providing an indication of the obtained product recommendation to a wearer of the device.

Abstract: A computer-implemented method of comparing one or more genetic traits of two users. Each user has a wearable device storing data indicative of the one or more genetic traits, the data having been obtained by an analysis of a biological sample provided by the user. The method comprises: transmitting the data indicative of the one or more genetic traits from a first of the wearable devices to a first computer device using a short-range wireless data connection; transmitting the data from the first computer device to a second computer device over a data network; transmitting the data from the second computer device to a second of the wearable devices over a short-range wireless data connection; and comparing the data from the first wearable device with the data stored on the second wearable device to determine whether there is a match between the users' one or more genetic traits.

Abstract: A wrist-worn device having the form of a continuous loop. The device comprises a plurality of elongate links, each link comprising at least one magnet, the links being connected to form a chain with neighbouring links being pivotable with respect to one another about a pivot axis that is substantially radial with respect to said loop. The magnets of neighbouring links have a respective positioning and polarity to provide an attractive force between the pair of neighbouring links when the pair of neighbouring links are in a side-by-side arrangement, whereby the chain of links has a first configuration in which the links are retained by the attractive force in the side-by-side arrangement, and a second configuration of greater length than the first configuration.

Abstract: A surface or bulk acoustic wave device can be implanted in or worn on a human or animal body to monitor various parameters thereof. The device comprises a pair of interdigitated transducers spaced apart over the surface of a piezo-electric substrate that is exposed to the parameter to be monitored. The device is interrogated by a radio-frequency signal being supplied to one of the transducers and detected after reflection by the other transducer. The parameter is measured by comparison of the supplied and received signals.