Abstract: A method for spatiotemporal control of electrical energy consumption of a telecommunications network dependent on conditions in a power grid that is responsible for supplying the telecommunications network in space and time, includes detection of an overload on a power grid due to too high power supply by exchanging of information between the power grid monitoring unit and the telecommunications control unit, and an increase in power consumption by the telecommunications network in the spatial area, through configuration of the telecommunications network components in this spatial area by the power grid monitoring unit for the period of too high power supply.

Abstract: The present invention relates to novel crystalline forms of ceftaroline fosamil and to methods for their preparation. Furthermore the present invention relates to the use of the novel forms of ceftaroline fosamil for the preparation of an antibiotic medicament. In addition the present invention relates to pharmaceutical compositions comprising an effective amount of the novel forms of ceftaroline fosamil and to methods of preparing the same. Finally the present invention relates to pharmaceutical combinations comprising an effective amount of the novel forms of ceftaroline fosamil and ?-lactamase inhibitors.

Abstract: The present invention relates to non-stoichiometric crystalline hydrates of 1-(?-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene, processes for their preparation, and their use as medicaments. In addition the present invention relates to pharmaceutical compositions comprising an effective amount of the novel crystalline hydrates.

Abstract: A rotor wheel for a turbomachine, particularly a radial turbomachine, having a rotor wheel face and a shrink collar adjoining the rotor wheel face for shrinking onto a rotor of the turbomachine and a circumferential groove between the rotor wheel face and the shrink collar.

Abstract: The invention relates to a mass-spectrometric method to determine microbial resistances to antibiotics, in which the microbes are cultured in a medium comprising an antibiotic, and a mass spectrum of the microbes is acquired after they have been cultured. The method is characterized by the fact that any microbial growth taking place during the culture is mass-spectrometrically determined with the aid of a reference substance, which is added in a dosed amount and is co-measured in the mass spectrum, wherein a growth in microbes indicates the resistance to the antibiotic.

Abstract: A method for adaptive configuration of a transmission signal in a coherent Wavelength-Division Multiplexing-Passive Optical Network (WDM-PON) having an optical line termination and a plurality of end nodes includes: (a) generating, by at least m lasers, the transmission signal; (b) monitoring the ka active end nodes; (c) if the number of active end nodes is reduced to ka?(m?1)*p: reassigning active end nodes associated with a spectral range of a laser to be switched off to a respective free spectral range of another laser, announcing the new assignment of the spectral ranges by transmitting a message to one or more end nodes assigned to the laser to be switched off, and switching off the laser to be switched off; and (d) if the number of active end nodes increases to ka>m*p: switching on an additional laser.

Abstract: The present invention relates to novel polymorphic forms of Saxagliptin Hydrochloride. The present invention also relates to methods of making polymorphic forms of Saxagliptin Hydrochloride.

Abstract: The invention relates to an amorphous form of telaprevir, its preparation via novel crystalline Form C of telaprevir (also referred to as “crystalline Form C” or “Form C”), and telaprevir compositions comprising said amorphous form and Form C. Furthermore, the present invention relates to the use of said amorphous telaprevir, telaprevir composition and Form C of telaprevir for the preparation of medicaments such as anti-hepatitis C medicaments. Moreover, the present invention relates to pharmaceutical compositions and dosage forms comprising a pharmaceutically effective amount of said novel forms for use in treating patients suffering from hepatitis C virus.

Abstract: A coupling arrangement between a fluid reservoir and a main brake cylinder for a motor vehicle brake system includes two coupling arms with one coupling aperture each on one of the fluid reservoir or main brake cylinder. The other of the fluid reservoir or main brake cylinder has a mounting portion with a receiving aperture. The coupling apertures and the receiving aperture are aligned with each other along a common axis and accept a coupling bolt. The coupling bolt is configured with a cylindrical shank portion and at least one radially protruding detent projection. At least one of the coupling arms includes a support portion, which has a support surface that radially supports the cylindrical shank portion. Part of the support portion is configured to be elastically deformable with the detent projection to produce a detent connection. The remaining part of the support portion is configured to be substantially deformation-resistant.

Abstract: Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful in predicting CF disease progression and assessing a CF subject's response to therapy.

Abstract: A method for spatiotemporal control of electrical energy consumption of a telecommunications network dependent on conditions in a power grid that is responsible for supplying the telecommunications network in space and time, includes detection of an overload on a power grid due to too high power supply by exchanging of information between the power grid monitoring unit and the telecommunications control unit, and an increase in power consumption by the telecommunications network in the spatial area, through configuration of the telecommunications network components in this spatial area by the power grid monitoring unit for the period of too high power supply.

Abstract: A method for adaptive configuration of a transmission signal in a coherent Wavelength-Division Multiplexing-Passive Optical Network (WDM-PON) having an optical line termination and a plurality of end nodes includes: (a) generating, by at least m lasers, the transmission signal; (b) monitoring the ka active end nodes; (c) if the number of active end nodes is reduced to ka?(m?1)·p: reassigning active end nodes associated with a spectral range of a laser to be switched off to a respective free spectral range of another laser, announcing the new assignment of the spectral ranges by transmitting a message to one or more end nodes assigned to the laser to be switched off, and switching off the laser to be switched off; and (d) if the number of active end nodes increases to ka>(m?1)·p: switching on an additional laser.

Abstract: The present invention provides a reliable process for the preparation of polymorphic pure form A of Bazedoxifene x acetate. In addition, the present invention relates to a process of wet granulation of polymorphic pure form A of Bazedoxifene x acetate. The present invention also relates to pharmaceutical compositions comprising polymorphic pure form A of Bazedoxifene x acetate as well as to the use of cyclic ethers for the preparation of such pharmaceutical composition.

Abstract: A method of dynamically allocating network resources in an access network and a customer network includes: determining, by a control unit, positions of all users of the customer network; bringing, by the control unit, the customer network and/or a component of the customer network into a first predefined state, based on determining that no user of the customer network is checked in to the customer network; and reallocating, by the control unit, an access port of an access multiplexer assigned to the customer network to an access network resource pool, based on determining that no user of the customer network is checked in to the customer network.

Abstract: An inlet connection piece for an axial compressor, particularly for a turbocompressor, includes an inlet housing (1) in which is arranged a bearing housing (2) with a bearing (3), particularly a radial and/or axial bearing, for a rotor. The bearing housing (2) is connected to the inlet housing (1) by an inlet strut (4) which is connected to the inlet housing in a front cross section. The center of the bearing (3) is arranged axially in the flow direction of a fluid to be compressed behind the area center of the front cross section by at least 0.1-times, particularly at least 0.15-times, particularly at least 0.2-times, particularly at least 0.25-times, the chord length of the front cross section. In addition or alternatively, a fluid passage (5, 6) is formed in the inlet strut (4), and at least portions of this fluid passage (5, 6) form an acute angle with a normal plane relative to the longitudinal axis of the inlet connection piece.

Abstract: A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to an address snapshot and an approval process definition business object.

Abstract: The present invention relates to crystalline form I of Febuxostat as well as to pharmaceutical compositions comprising crystalline form I as an active pharmaceutical ingredient. Furthermore the present invention relates to a further polymorphic form of Febuxostat designated as form II and to a novel solvate of Febuxostat. The present invention also relates to methods of making crystalline form I, form II and the novel solvate of Febuxostat.

Abstract: The invention relates to a mass spectrometric method for determining microbial resistances to antibiotics. The invention provides specific methods comprising cultivation in synthetic media, in which several amino acids, preferably only a single amino acid, are isotopically labeled by incorporating 13C, 15N, 18O or 34S. If several amino acids are isotopically labeled, they are labeled in such a way that they are each heavier than the corresponding unlabeled amino acids by the same integer mass difference ?m. This ensures that the mass shifts of the peaks always amount to an integer multiple of the mass difference ?m. The total mass difference can be kept relatively small by selecting suitable amino acids. A mass shift of the protein peaks in media with antibiotics indicates that the microbes are resistant. A second embodiment first produces isotopically labeled microbes, which are then tested for their resistance by cultivating them in normal media.

Abstract: The present invention provides a reliable process for the preparation of polymorphic pure form A of Bazedoxifene x acetate. In addition, the present invention relates to a process of wet granulation of polymorphic pure form A of Bazedoxifene x acetate. The present invention also relates to pharmaceutical compositions comprising polymorphic pure form A of Bazedoxifene x acetate as well as to the use of cyclic ethers for the preparation of such pharmaceutical composition.

Abstract: Genetic data may be compressed efficiently by selecting for each bi-allelic marker, from among multiple compression algorithms with different associated storage requirements that depend on the minor allele frequency of the respective marker, the algorithm that has the lowest storage requirements. Efficient approaches compress, store, and load pedigree file data. A hybrid method is used that selects between multiple alternative compression algorithms whose performance depends on the frequency of certain observable genetic variations. The hybrid method may achieve higher compression ratios than PLINK or PBAT. Further, it results in a compressed data format that, generally, does not require any overhead memory space and CPU time for decompression, and, consequently, has shorter loading times for compressed files than the binary format in PLINK or PBAT.