Abstract: The present invention relates to novel polymorphic forms of Saxagliptin Hydrochloride. The present invention also relates to methods of making polymorphic forms of Saxagliptin Hydrochloride.

Abstract: A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to an address snapshot and an approval process definition business object.

Abstract: The present invention relates to a pharmaceutical composition comprising crystalline form Y of posaconazole. The pharmaceutical composition can be used to treat or prevent fungal infections.

Abstract: The present invention relates to crystalline form I of Febuxostat as well as to pharmaceutical compositions camprising crystalline form I as an active pharmaceutical ingredient. Furthermore the present invention relates to a further polymorphic form of Febuxostat designated as form II and to a novel solvate of Febuxostat. The present invention also relates to methods of making crystalline form I, form II and the novel solvate of Febuxostat.

Abstract: The present invention relates to crystalline form IV of posaconazole and pharmaceutical compositions comprising the same. The pharmaceutical composition can be used to treat or prevent fungal infections.

Abstract: Axial-radial flow machine having an axial portion with at least one axial stage, a radial portion with at least one radial stage, a housing having an interior space with a dividing wall extending in a radial direction dividing the housing in an axial direction into a first partial space in which the axial portion is received and a second partial space in which the radial portion is received, and a shaft that extends in axial direction through the interior space and through the dividing wall and on which impellers of the axial portion and of the radial portion are received. A radial gap is formed between the dividing wall and a fluid guiding element of the radial portion. The fluid guiding element is axially fixed to the housing so as to be adjacent to the dividing wall. A plurality of fixing units which are distributed in circumferential direction are arranged in the radial gap, each of which fixing units axially fixes the dividing wall to the fluid guiding element.

Abstract: A rotor wheel for a turbomachine, particularly a radial turbomachine, having a rotor wheel face and a shrink collar adjoining the rotor wheel face for shrinking onto a rotor of the turbomachine and a circumferential groove between the rotor wheel face and the shrink collar.

Abstract: The present invention relates to stable amorphous 3-De[(2,6-dideoxy-3-C-methyl-3-O-methyl-?-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin (telithromycin), methods for the preparation thereof, the use of stable amorphous telithromycin in the treatment of bacterial infections and to pharmaceutical compositions comprising stable amorphous telithromycin.

Abstract: Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful in predicting CF disease progression and assessing a CF subject's response to therapy.

Abstract: The present invention relates to crystalline form II-S, its preparation and its use to prepare other crystalline forms of posaconazole, in particular crystalline form IV of posaconazole.

Abstract: The present invention relates to novel polymorphic forms of Saxagliptin Hydrochloride. The present invention also relates to methods of making polymorphic forms of Saxagliptin Hydrochloride.

Abstract: Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful in predicting CF disease progression and assessing a CF subject's response to therapy.

Abstract: Disclosed herein are novel methods, assays and systems for detecting an increased risk for Alzheimer's disease (AD) in a subject by identifying at least one nuclei acid polymorphism described herein in a biological sample from the subject. Levels of the genes associated with the nucleic acid polymorphism described herein are also determined for detection of higher risk for AD. Disclosed herein further provides methods for treating AD by administering to a subject in need thereof with ATXN1.

Abstract: The present invention relates to a pharmaceutical composition comprising crystalline form Y of posaconazole. The pharmaceutical composition can be used to treat or prevent fungal infections.

Abstract: The present invention relates to crystalline form IV of posaconazole and pharmaceutical compositions comprising the same. The pharmaceutical composition can be used to treat or prevent fungal infections.

Abstract: An inlet connection piece for an axial compressor, particularly for a turbocompressor, includes an inlet housing (1) in which is arranged a bearing housing (2) with a bearing (3), particularly a radial and/or axial bearing, for a rotor. The bearing housing (2) is connected to the inlet housing (1) by an inlet strut (4) which is connected to the inlet housing in a front cross section. The center of the bearing (3) is arranged axially in the flow direction of a fluid to be compressed behind the area center of the front cross section by at least 0.1-times, particularly at least 0.15-times, particularly at least 0.2-times, particularly at least 0.25-times, the chord length of the front cross section. In addition or alternatively, a fluid passage (5, 6) is formed in the inlet strut (4), and at least portions of this fluid passage (5, 6) form an acute angle with a normal plane relative to the longitudinal axis of the inlet connection piece.

Abstract: Systems and methods are provided for processing an electronic document by one or more computer network components having network addresses in a computer network. Within the electronic document, a plurality of approval items are identified that require status manipulation operations within the electronic document. These approval objects may be grouped together based on the properties of the approval items to form one or more approval objects. Thereafter, each approval object is associated with one or more computer network components based on the properties of the approval object, so that each approval object may be routed to the network addresses of the associated computer network components for status manipulation processing. Depending on the results of the status manipulation processing, a follow-on data set may be generated for the electronic document and sent to one or more additional computer network components.

Abstract: The present invention relates to stable amorphous 3-De[(2,6-dideoxy-3-C-methyl-3-O-methyl-?-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin (telithromycin), methods for the preparation thereof, the use of stable amorphous telithromycin in the treatment of bacterial infections and to pharmaceutical compositions comprising stable amorphous telithromycin.

Abstract: System and methods are described for automatically determining the responsible agent for a given task. Using a task grammar, a task constructor constructs a request description. A responsibility request, including the request description, is formulated. A rules engine queries a database and determines, given the request description, the responsible agent for the given task by matching the request description with a task description in the database and returning the responsible agent associated with the task description.

Abstract: A brake fluid reservoir (10) for a vehicle hydraulic brake system has a filler neck (16), a lid (18) which closes the filler neck, and a device for pressure compensation between the reservoir interior and the ambient atmosphere. In order, when the brake fluid reservoir (10) is in a steeply inclined position, to prevent an escape of brake fluid, in the lid (18) a first brake fluid forced-flow channel (32) is formed, which has an inlet (34) at the inside of the lid and an outlet (36) towards the outside of the lid. The forced-flow channel (32) extends between the inlet (34) and the outlet (36) along a curved path, which in relation to a plan view of the lid (18) runs through at least two quadrants.