Abstract: This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing obesity, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the animal or human subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing obesity.

Abstract: This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.

Abstract: An actuating device, particularly for actuating valves connected externally, includes a housing (10) and a coil body (12) arranged in the housing. The coil body has a coil winding (14) at least partially enclosing a coil tube (16), a pole core (20) connected at the coil tube free end, an armature (22) guided in a longitudinally displaceable manner at least in the pole tube (16) within an armature chamber (24) and interacting with an actuating part (26) for actuating the respective valve part. The pole tube (16) is designed as a receiving sleeve for the armature (22). The sleeve is fixed with its free end region to a fixed bearing point. The fixed bearing point is formed by two support parts (118, 124) of the pole core (20) that delimit a receiving gap between them, in which the free end region of the receiving sleeve is fixed in a clamped manner.

Abstract: A media displacement device has a body configured to be positioned radially outwards of a tool having an antenna for transmitting electromagnetic energy to or receiving electromagnetic energy from an earth formation. The body is made of materials causing less power loss to electromagnetic energy transmitted or received by the tool than the media the body is configured to displace.

Abstract: The present invention relates to methods and devices for the modelling tendinous tissue into a desired shape. The shaped tissue produced by the methods of the present invention is useful in any field relating to biological tissue, particularly in the field of medicine, most preferred in surgery, for intraoperative use or pre- or peri-operative preparation of the tissue.

Abstract: A method performed in a network element for reacting to communication performance measurements that fall outside of communication performance thresholds. The network element generates a communication performance measurement between a first endpoint and a second endpoint, wherein each endpoint is a point of communication in the network and at least the first endpoint resides on the network element. The network element retrieves a communication performance threshold and determines whether the communication performance measurement falls outside of the communication performance threshold. The network element generates a trigger associated with the communication performance measurement and the communication performance threshold when it is determined that the communication performance measurement falls outside of the communication performance threshold.

Abstract: The invention relates to a production method for producing seamless, integral aircraft fuselage sections. The method comprises the following steps: a) application of a first vacuum film to a stable winding core and evacuation of the first vacuum film, b) depositing of the fuselage section in layers on the winding core by wrapping the same, c) application of an outer mould that is unstable compared to the stable winding core, to the fuselage section, wherein the winding core stabilises the outer mould, d) application of a second vacuum film to the outer mould, e) aeration of the first vacuum film and evacuation of the second vacuum film in order to draw the fuselage section closer to the outer mould and detach it from the winding core at least in one region, a) curing of the entire arrangement in an autoclave to produce the finished fuselage section.

Abstract: This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing obesity, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the animal or human subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing obesity.

Abstract: This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.

Abstract: The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

Abstract: The invention relates to a method for producing an electromagnetic actuating device, particularly for actuating valves, an armature (3) being formed within a pole tube (1) guiding an armature space (11) by configuring a mechanical connection between a pole body (13) and at least one further part (9, 15) of the pole tube (1), such as the pole core (9), characterized in that the mechanical connection is formed by thermal shrinking, such that the tube body (13) is heated and pressed onto the further part (9, 15).

Abstract: A revision connector is configured to couple a new spine fixation rod to a previously implanted spine fixation rod that is secured to a plurality of vertebrae. The new spine fixation rod can be implanted and secured to vertebrae that are caudal and/or cranial with respect to the previously secured vertebrae.

Abstract: The invention relates to an actuating device, particularly for actuating valves that can be connected externally, comprising a housing (10) and a coil body (12) arranged therein and having a coil winding (14), which at least partially encloses a coil tube (16), having a pole core (20) connected at the free end thereof, further comprising an armature (22) that is guided in a longitudinally displaceable manner at least in the pole tube (16) within an armature chamber (24) and interacts with an actuating pan (26) for actuating the respective valve part, wherein the pole tube (16) is designed as a receiving sleeve for the armature (22), said sleeve being fixed with the free end region thereof to a fixed bearing point, and wherein the fixed bearing point is formed by two support parts (118,124) of the pole core (20) that delimit a receiving gap between them, in which the free end region of the receiving sleeve is fixed in a clamped manner.

Abstract: An optoelectronic sensor arrangement (1), with a plurality of optical transmitters (21, 22) positioned side by side in an optical transmitter strip (12), such that each optical transmitter (21, 22) transmits the light of a transmitted cone (?1, ?2) into a surveillance area (50), and with a plurality of optical receivers (31, 32) positioned side by side in an optical receiver strip (14), which optical receivers (31, 32) receive the light of a received cone (?1, ?2) from the surveillance area (50), where each receiver (31, 32)comprises a spatially-resolving element (41, 42), such that each optical transmitter (21, 22) and optical receiver (31, 32) form an optical receiver/transmitter pair, and a control unit contains means for determining the optical incident point (L1, L1?, L2, L3) on one of the optical receivers (31, 32) of the transmitted cone (?1, ?2) of each optical transmitter (21, 22) and/or of a foreign light source (G1).

Abstract: The invention relates to a method and a device for adjusting the steering wheel of a motor vehicle. The aim of the invention is to enable an automatic adjustment of the steering wheel in the steering clearance center by ‘stabilizing’ or carrying out a steering hysteresis measurement, and the subsequent adjustment of the steering wheel, in a simple, rapid and cost-effective manner. To this end, the invention relates to a method for adjusting the steering wheel of a motor vehicle in the steering wheel clearance center, the method being characterized by the following steps: the floating plates of the vehicle geometry test bed, on which the front wheels of the motor vehicle are arranged, are rotated when the wheels are stopped in order to cause the rotation of steering wheel; the steering wheel angle is determined according to the triggered steering wheel movement; and the steering wheel clearance center is adjusted.

Abstract: A method of illuminating at least two illumination points by means of at least one spatial light modulator, said at least one spatial light modulator comprising a plurality of light modulators, whereby a predefined amount of energy transmitted to said points is at least partly controlled by varying the number of said light modulators illuminating said point.

Abstract: The invention relates to a method and a device for adjusting the steering wheel of a motor vehicle. The aim of the invention is to enable an automatic adjustment of the steering wheel in the steering clearance center by ‘stabilizing’ or carrying out a steering hysteresis measurement, and the subsequent adjustment of the steering wheel, in a simple, rapid and cost-effective manner. To this end, the invention relates to a method for adjusting the steering wheel of a motor vehicle in the steering wheel clearance center, the method being characterized by the following steps: the floating plates of the vehicle geometry test bed, on which the front wheels of the motor vehicle are arranged, are rotated when the wheels are stopped in order to cause the rotation of steering wheel; the steering wheel angle is determined according to the triggered steering wheel movement; and the steering wheel clearance center is adjusted.

Abstract: The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

Abstract: The invention relates to an actuating device, particularly for actuating externally connected valves, comprising a housing (10) and a coil member (12). Said coil member (12) is disposed in the housing (10), is provided with a coil winding (14), and at least partially encompasses a pole tube (16). A pole core (20) adjoins one free end of said pole tube (16). The actuating device further comprises at least one armature (22) which is guided within an armature chamber (24) at least in the pole tube (16) and cooperates with a part for actuating the respective valve. In order to dispense with the need for an independent lift stop used in prior art, the pole tube (16) is configured like a receiving jacket for the armature (22), one free end of said receiving jacket being provided with an inward-facing folded edge so as to foam a stop area (38) for the armature (22).

Abstract: An electric machine includes a laminated stator core having slots for receiving a stator winding, and a corona shield for insulating the stator winding. The corona shield includes a substrate; and a coating applied on the substrate, wherein the substrate and the coating are made entirely of inorganic material.