Abstract: A waveguide coupling device for a radar sensor is provided, including: a waveguide configured to emit a radar signal via a radiating end of the waveguide; and a fin part with at least one excitation fin, via which a radio frequency (RF) signal can be coupled into the waveguide for generating the radar signal, the waveguide and the fin part being formed in two parts, and the fin part being mechanically coupled to an excitation end of the waveguide opposite the radiating end of the waveguide.

Abstract: A filter device for ambient air filtration has a blower housing with air inlet and air outlet. A device for generating an air flow is arranged in the blower housing and generates an air flow in operation from air inlet to air outlet. A flexible air conducting hose is provided with a first open end connected to the air outlet of the blower housing and with a second closed end. The flexible air conducting hose has openings arranged between first open end and second closed end. Filter elements are arranged in the openings, respectively. The filter elements separate a raw side inside the air conducting hose from a clean side downstream of the filter element. The air conducting hose is inflated in operation of the device by the air flow. The flexible air conducting hose has a reduced air permeability compared to the air permeability of the filter elements.

Abstract: The invention relates to the treatment and prevention of diseases and conditions associated with EBV infection. In particular, the invention is directed to the use of an IDO1 inhibitor for the treatment and prevention of diseases and conditions associated with EBV infection. The invention also relates to methods for predicting the risk of developing a disease or condition associated with EBV infection.

Abstract: This application relates to amatoxin analogs in which the trans-4-substituent on the proline residue of the amatoxin is an R group other than a hydroxy, constructs comprising such amatoxin analogs coupled to a linker and conjugates comprising such amatoxin analog-linker constructs conjugated to a target moiety. The application also relates to uses of such amatoxin analogs, for example, in treatment of cancer.

Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention relates to a multi-layer thin film comprising at least two layers arranged one on top of the other which each comprise at least one polymer, these at least two layers being connected to one another by at least one stitched seam using at least one thread, and to a method for producing such a thin film and to the use thereof as a medicament.

Abstract: The present invention relates to a computer-implemented method for identifying an incorrectly or non-calibrated infrared spectrometer, comprising the steps of a) recording an infrared spectrum of a sample with a first infrared spectrometer to provide a sample infrared spectrum, b) recording an infrared spectrum of the same sample as in step a) with a second infrared spectrometer to provide a reference infrared spectrum, wherein said second spectrometer is a correctly calibrated infrared spectrometer, or b?) providing a reference spectrum of the same sample as in step a), wherein said reference spectrum was recorded on a second infrared spectrometer, which is a correctly calibrated spectrometer, c) determining a difference between the wavelength of each extreme point in the sample of step a) and the wavelength of each extreme point in the reference spectrum of step b) or b?), and d) indicating the infrared spectrometer of step a) as incorrectly calibrated or non-calibrated, when at least one difference was det

Abstract: An antenna arrangement configured to radiate a high-frequency measurement signal from a measurement sensor is provided, including: an antenna made of a plastic material; a waveguide made of the plastic material, in which the waveguide is integrally formed with the antenna; and a wall on an outside of the antenna that has metallization or is made of metal. A measuring device including a measurement sensor and the antenna arrangement is also provided. A method of manufacturing an antenna arrangement is also provided, the method including: providing an antenna arrangement having an antenna and a waveguide made of a plastic by an injection molding process, a micro injection molding process, a compression molding of a base body, or a 3D printing process, in which the waveguide is integrally formed with the antenna; and metallizing an exterior of the antenna to form a wall on the exterior of the antenna.

Abstract: A cookware item includes: a cooking container for receiving food to be cooked and/or a lid for closing the cooking container; at least one handle for handling the cookware item, a handle body of the handle being force-transmittingly connected to the cooking container and/or to the lid of the cookware item by a handle connection part of the handle; an insulating part of the cookware item being disposed between the handle connection part and/or the lid to reduce a transfer of heat to the handle body; and an output unit at least partially integrated into the handle body and for visually outputting information to a user of the cookware item, the output unit having at least one light source, the light source being controllable by a controller of the cookware item and configured to be supplied with electrical power by a power source of the cookware item.

Abstract: A cooking vessel includes: a vessel body with at least one handle arranged on the vessel body, the vessel body delimiting a space for receiving food to be cooked, which space is open at a top in a use position of the cooking vessel and is intended for receiving food to be cooked, the vessel body having an outer shell which is connected or connectable to the handle, and an inner shell which is connected to the outer shell when the cooking vessel is assembled, the outer shell receiving the inner shell when the cooking vessel is assembled, and the space for receiving food to be cooked being formed in the inner shell. A wall inner face of the outer shell, which faces the inner shell, and a wall outer face of the inner shell, which faces the outer shell, are each conical.

Abstract: A cookware item includes: a cooking container for receiving food to be cooked and/or a lid for closing the cooking container; at least one handle for handling the cookware item, a handle body of the handle being force-transmittingly connected to the cooking container and/or to the lid of the cookware item by a handle connection part of the handle; an insulating part of the cookware item being disposed between the handle connection part and/or the lid to reduce a transfer of heat to the handle body; and an output unit at least partially integrated into the handle body and for visually outputting information to a user of the cookware item, the output unit having at least one light source, the light source being controllable by a controller of the cookware item and configured to be supplied with electrical power by a power source of the cookware item.

Abstract: A guide vane ring and/or a rotor blade ring for a low-pressure turbine of an aircraft gas turbine of a turbofan engine includes a plurality of airfoils disposed consecutively in a direction of rotation. The plurality of airfoils includes a first airfoil and a second airfoil adjacent to the first airfoil in the direction of rotation. The first and second airfoils are disposed relative to each other such that a ratio e/t, viewed in a conical section, results from a smallest free flow cross-section e taken on the pressure side of the first airfoil from its trailing edge to a suction side of the second airfoil, and a pitch t of the airfoils, such that e/t is less than 0.31, (e/t<0.31).

Abstract: A method for operating a cooking system, the cooking system including a hob, cookware, and a mobile device, includes: transmitting a process instruction from the mobile device to the hob; receiving the process instruction from the mobile device by the hob; transmitting a confirmation request from the hob to the cookware; in response to a confirmation by a user on the cookware, transmitting a confirmation message from the cookware to the hob; and in response to the hob receiving the confirmation message from the cookware, executing the process instruction of the mobile device by the hob.

Abstract: A couch top extension includes a first section and a second section extending from the first section. The first section has a varying shape profile and the second section has a substantially uniform shape profile. A couch top extension includes an extension board comprising one or more identifiers capable of providing a detectable signal indicative of an identification of the extension board.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention relates to prodrugs comprising a linker comprising five- or six-membered cyclic acetals and an adjacent specific cleavage site, and to precursor compounds for the synthesis of said prodrugs. In one aspect the present invention relates to antibody-targeted amatoxin conjugates comprising said linkers, to methods for their synthesis, and to the use of said antibody-targeted amatoxin conjugates. In a further aspect, the invention relates to pharmaceutical compositions comprising said conjugates, and to the use of said conjugates or compositions for therapeutic purposes, in particular for tumor therapy and oncology.

Abstract: Amatoxins, as well as antibody-drug conjugates (ADCs) comprising an amatoxin are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can be used for cancer therapy. They can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, as well as prevention of graft-versus-host-disease (GVHD), are provided.

Abstract: A method for operating a cooking system includes: providing at least one cooking hob device, at least one kitchen utensil, and at least one evaluation device, the cooking hob device including at least one placement surface on which to place kitchen utensils and at least one generator device having at least two induction devices for heating the kitchen utensil placed on the placement surface, and the kitchen utensil being heatable by at least one induction device; assigning at least one transmitting device to each of the at least two induction devices of the cooking hob device, the kitchen utensil including at least one receiving device, each transmitting device of the at least one transmitting device emitting at least one electromagnetic signal, at least intermittently, which signal is received by the receiving device of the kitchen utensil when the kitchen utensil is heated by the corresponding induction device.