Abstract: The invention relates to a method for producing a cushion for an orthopedic device, the cushion having a first component, which comprises a first film layer and a second film layer, and a second component that are joined with each other in such a way that there is at least one fluid-filled volume between the first component and the second component, the method comprising the following steps: inserting the first film layer, which has at least one opening, and the second film layer into a tool, which has an upper mold and a lower mold; applying a differential pressure to at least one of the film layers, so that the at least one film layer moves at least in sections towards the upper mold or the lower mold, thereby creating a distance between the two films; joining the two film layers along at least one connection line.

Abstract: The invention relates to a method for producing a cushion for an orthopedic device, the cushion having at least one fluid-filled volume, wherein the method includes compression molding of a three-dimensional first cushion component made of at least a first material, which is preferably elastic, in a mold that comprises an inner mold and an outer mold, and bonding the first cushion component to at least a second cushion component in such a way that the fluid-filled volume is created.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: The present application relates to a composition comprising (a) at least one immune checkpoint inhibitor and (b) at least one conjugate, wherein said conjugate is comprising (i) a target binding moiety, (ii) at least one amatoxin, and (iii) optionally at least one linker connecting said target binding moiety with said at least one amatoxin. The present application further relates to said composition for use in treating a patient having a cancer, and to a pharmaceutical formulation comprising said composition and additional excipients, as well as to methods of producing and using said composition (FIG. 1).

Abstract: The present invention relates to a composition comprising proteins identified in barn dust extract or peptides derived from one of the proteins. The composition is useful in the prevention or treatment of a disease.

Abstract: A temperature sensor assembly including a carrier part having a receptacle for a temperature pin, a sensor element for measuring a temperature, and a pushing element pushing the sensor element into the receptacle.

Abstract: A radar module configured for plant monitoring is provided, including: a microwave chip including a radar signal source configured to generate a radar signal; a coupling element connected to the radar signal source by a signal link; and a resonant cavity into which the coupling element projects, the coupling element being configured to couple the radar signal into the resonant cavity, and the resonant cavity being integrated in the microwave chip.

Abstract: A radio frequency unit for use in a potentially explosive atmosphere is provided, including: a carrier element, on which a radio frequency element is arranged, the radio frequency element being configured to transmit and/or receive a radio frequency signal; a housing, which delimits the radio frequency element at least in sections; and an excitation element arranged on the radio frequency element and configured to transmit the radio frequency signal, an inside of the housing being potted with a potting compound. A fill level measuring device including the radio frequency unit , and a method of manufacturing the radio frequency unit, are also provided.

Abstract: A radar circuit for a level measuring device is provided, including: a first application-specific integrated circuit (ASIC); and a second ASIC, the first ASIC having a first structure size and/or being manufactured by a first semiconductor technology, the second ASIC having a second structure size and/or being manufactured by a second semiconductor technology, the first structure size being different from the second structure size, and/or the first semiconductor technology being different from the second semiconductor technology.

Abstract: A radar circuit for a measuring device is provided, including: a radar chip, configured to generate a radar measurement signal; an application-specific integrated circuit (ASIC); and a processor, configured to determine a measured value, the ASIC and the radar chip being separate components.

Abstract: A waveguide coupling device for a radar sensor is provided, including: a waveguide configured to emit a radar signal via a radiating end of the waveguide; and a fin part with at least one excitation fin, via which a radio frequency (RF) signal can be coupled into the waveguide for generating the radar signal, the waveguide and the fin part being formed in two parts, and the fin part being mechanically coupled to an excitation end of the waveguide opposite the radiating end of the waveguide.

Abstract: A measuring device for process automation in an industrial or private environment is provided, including: a sensor circuit configured to detect one or more measured variables; and a control circuit configured to determine a measurement result from the detected one or more measured variables and to determine a difference between a temperature of the sensor circuit and a reference temperature detected during a calibration of a self-test function of the measuring device, the control circuit being further configured to perform a correction of the measurement result depending on the difference between the temperature of the sensor circuit and the reference temperature during execution of the self-test function. A method for performing a correction of a measurement result of a measuring device for process automation in an industrial or private environment is also provided.

Abstract: Marfan Syndrome is a pathology responsible for a high morbidity and mortality. Apart from surgery, treatment options are limited. It is therefore essential to develop new pharmacological approaches to limit aortic dilatation and/or rupture. Now, the inventors have demonstrated a critical role for TREM-1 in the pathophysiology of ascending aortopathy related to Marfan disease, In particular, the inventors showed that i) TREM-1 is expressed by macrophages in the aortic wall of Marfan patients, ii) TREM-1 is expressed by macrophages in the aortic wall of Marfan mice, and iii) TREM-1 deficiency protects against aortic rupture in a mouse model of Marfan syndrome. Blocking TREM-1 could therefore be a therapeutic approach for Marfan-related aortopathy.

Abstract: A placeable cooktop utensil includes: a handle for handling the placeable utensil; a controller; a transmitter unit for transmitting signals from the placeable utensil to the cooktop; and at least one input unit having at least one input area integrated in the handle for a user of the placeable utensil to input a user command, the transmitter unit and the at least one input unit being connected in signal communication with the controller, and the cooktop being controllable by the user command. The handle has a gripping portion for gripping and manually moving the placeable utensil and at least one input portion. The at least one input area is in the at least one input portion. At least one sensor for detecting the handle being approached and/or contacted by the user, is in the gripping portion.

Abstract: A method for monitoring a vehicle (1) having a vehicle superstructure (2), a chassis (3) connected to the vehicle superstructure (2), and a monitoring unit (11) which monitors the chassis (3) for damage. In the event that chassis damage is detected, the monitoring unit produces a warning signal (S) by means of a warning signal generator, where the warning signal generator has at least one drive unit (10) by means of which the warning signal (S) is produced in the form of a tactile mechanical vibration.

Abstract: A waveguide coupling device for a radar sensor is provided, including: a waveguide configured to emit a radar signal via a radiating end of the waveguide; and a fin part with at least one excitation fin, via which a radio frequency (RF) signal can be coupled into the waveguide for generating the radar signal, the waveguide and the fin part being formed in two parts, and the fin part being mechanically coupled to an excitation end of the waveguide opposite the radiating end of the waveguide.

Abstract: This application relates to amatoxin analogs in which the trans-4-substituent on the proline residue of the amatoxin is an R group other than a hydroxy, constructs comprising such amatoxin analogs coupled to a linker and conjugates comprising such amatoxin analog-linker constructs conjugated to a target moiety. The application also relates to uses of such amatoxin analogs, for example, in treatment of cancer.

Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention relates to a computer-implemented method for identifying an incorrectly or non-calibrated infrared spectrometer, comprising the steps of a) recording an infrared spectrum of a sample with a first infrared spectrometer to provide a sample infrared spectrum, b) recording an infrared spectrum of the same sample as in step a) with a second infrared spectrometer to provide a reference infrared spectrum, wherein said second spectrometer is a correctly calibrated infrared spectrometer, or b?) providing a reference spectrum of the same sample as in step a), wherein said reference spectrum was recorded on a second infrared spectrometer, which is a correctly calibrated spectrometer, c) determining a difference between the wavelength of each extreme point in the sample of step a) and the wavelength of each extreme point in the reference spectrum of step b) or b?), and d) indicating the infrared spectrometer of step a) as incorrectly calibrated or non-calibrated, when at least one difference was det

Abstract: An antenna arrangement configured to radiate a high-frequency measurement signal from a measurement sensor is provided, including: an antenna made of a plastic material; a waveguide made of the plastic material, in which the waveguide is integrally formed with the antenna; and a wall on an outside of the antenna that has metallization or is made of metal. A measuring device including a measurement sensor and the antenna arrangement is also provided. A method of manufacturing an antenna arrangement is also provided, the method including: providing an antenna arrangement having an antenna and a waveguide made of a plastic by an injection molding process, a micro injection molding process, a compression molding of a base body, or a 3D printing process, in which the waveguide is integrally formed with the antenna; and metallizing an exterior of the antenna to form a wall on the exterior of the antenna.