Abstract: Embodiments of the present disclosure include a hyperpolarizing system, comprising a hyperpolarization reaction chamber having a location therein for supporting a solid catalyst with a sample in contact therewith, a cooler configured to lower a temperature of the sample and the solid catalyst to a temperature in a range of about 70K and about 250K, and an optical light source configured to direct light energy toward the solid catalyst to thereby hyperpolarize electrons in the solid catalyst and facilitate transfer of hyperpolarization to nuclei of the sample.

Abstract: The invention relates to a method for displaying a notification for a user in which first image data associated with the notification is displayed on a display unit in a normal display mode. The method also includes displaying second image data associated with the notification on the display unit in a safety display mode as soon as a predetermined fault condition is satisfied in the normal display mode. The predetermined fault condition being satisfied is checked by comparing a current display of the first image data by the display unit in the normal display mode, with respect to a presence of image faults, with a reference display of the first image data by the display unit in the normal display mode. The current display and the reference display are subdivided into regions and/or pixels for the comparison, said regions and/or pixels being associated with classes as background, foreground, image edge and/or irrelevant.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.

Abstract: A housing for a high-frequency chip in a radar device for level measurement is provided, including a high-frequency chip having a high-frequency terminal and a supply terminal; horizontal metal layers; vertical metal connecting lines; and an external supply terminal configured to connect the chip to a circuit board of the device, the chip being attached to one of the horizontal metal layers in an electrically conductive manner, and being embedded in a polymer compound, which is located between the horizontal metal layers, the supply terminal being connected to the external supply terminal via at least one of the horizontal metal layers and via at least one of the vertical metal connecting lines, and the high-frequency terminal being connected to an antenna configured to decouple and receive radar waves, via at least one of the horizontal metal layers and/or via at least one of the vertical metal connections.

Abstract: A radar transceiver chip for transmitting a transmission signal and for receiving a received signal is proposed. The radar transceiver chip includes a transmitting branch, a receiving branch, a coupler, by means of which the transmitting branch is coupled to the receiving branch, and exactly one antenna terminal for connecting an external antenna to the radar transceiver chip. The coupler is coupled to the antenna terminal and is configured to output at least a portion of the transmission signal to the antenna terminal and to feed at least a portion of the received signal, received via the antenna terminal, into the receiving branch, the receiving branch comprising a receiving mixer which is configured to generate an intermediate frequency signal on the basis of the received signal.

Abstract: A printed circuit board for a radar level measurement device with a printed circuit board substrate is provided, wherein a microwave signal is coupled via a microwave conductor into a waveguide. A connection region on a front side of the printed circuit board substrate serves to receive the waveguide. A shape of a resonator shell is generated inversely by producing an annular peripheral recess whose wall has an electromagnetically reflecting coating on a rear side of the printed circuit board substrate. The annular peripheral recess on the rear side, together with a region surrounded by the recess, forms a resonator for the injected microwave signals.

Abstract: Formulation comprising (A) at least one aminocarboxylate selected from methylglycin diacetate (MGDA), iminodisuccinic acid (IDA) and glutamic acid diacetate (GLDA), and salts thereof, (B) at least one polypropyleneimine which may be alkoxylated.

Abstract: A radar fill level measurement device for determining a fill level of a medium is provided, including a radar module to generate a transmission signal of at least 60 GHz; and an antenna coupled to the module and to transmit the signal to a surface of the medium and to receive a reflected signal, the module including a phase-locked loop including a push-push oscillator and a phase detector, the oscillator including a first and second outputs, a duplexer coupled between the push-push oscillator and the antenna, and a frequency multiplier coupled between the oscillator second output and the duplexer, the oscillator first output being directly wired to the phase detector input, the duplexer being coupled to the antenna, the phase detector including a reference input and a phase detector output coupled to an oscillator control input. A method for operating a radar fill level measurement device is also provided.

Abstract: A waveguide coupling for a fill level radar including a waveguide and a high-frequency chip, which projects at least in part into the waveguide and includes a coupling element for coupling the transmission signal into the waveguide.

Abstract: A method and device for the synchronization of processes, a first signal being sent by a clock-giving processor, the first signal having, in an alternating manner, first edges having a first direction and second edges having a second direction opposite the first edge, a temporal distance between at least one of the first edges and at least one of the second edges being determined as a function of a state of a counter in the clock-giving processor. A method for the synchronization of processes, a first signal being received by a clock-receiving processor, the first signal having, in an alternating manner, first edges having a first direction and second edges having a second direction opposite the first edge, a state of a counter in the clock-receiving processor being determined as a function of a temporal distance between at least one of the first edges and at least one of the second edges.

Abstract: The present invention relates to a process for preparing polyamines having a mean molecular weight of ?203 g/mol, in which the deviation from the mean molecular weight per ° C. of change in the reaction temperature is <19% of the mean molecular weight, by polycondensation of diamines in the liquid phase in the presence of heterogeneous catalysts based on transition metals of the eighth to eleventh transition groups of the Periodic Table of the Elements and hydrogen at temperatures of 100 to 250° C. and pressures in the range from 60 to 150 bar, to the polyamines obtainable by this process, and to the use of the polyamines.

Abstract: The invention relates to ?-amaninamide (1; x=0, 1 or 2), ?-amaninamidic acid (2; x=0, 1 or 2), and ?-amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of ?-amanitin (4), and methods and novel building blocks for the synthesis thereof.

Abstract: A radar fill level measurement device for determining a fill level of a medium is provided, including a radar module to generate a transmission signal of at least 60 GHz; and an antenna coupled to the module and to transmit the signal to a surface of the medium and to receive a reflected signal, the module including a phase-locked loop including an oscillator, a phase detector, and a frequency divider, coupled between the oscillator output and the phase detector input, and a duplexer coupled between the oscillator and the antenna, the oscillator output being directly wired to an input of the duplexer, the frequency divider and the duplexer being coupled to a same oscillator output, the phase detector including a reference input and a phase detector output that is coupled to a control input of the oscillator. A method for operating a radar fill level measurement device is also provided.

Abstract: A radar fill level measurement device for determining a fill level of a medium is provided, including a radar module to generate a transmission signal of at least 60 GHz; and an antenna coupled to the module and to transmit the signal to a surface of the medium and to receive a reflected signal, the module including a phase-locked loop including a push-push oscillator and a phase detector, the oscillator including a first and second outputs, a duplexer coupled between the push-push oscillator and the antenna, and a frequency multiplier coupled between the oscillator second output and the duplexer, the oscillator first output being directly wired to the phase detector input, the duplexer being coupled to the antenna, the phase detector including a reference input and a phase detector output coupled to an oscillator control input. A method for operating a radar fill level measurement device is also provided.

Abstract: The invention relates to a method for operating a transversal guidance system of a motor vehicle through two independent channels to perform automatic transversal guidance interventions. Through the first channel, transversal interventions are performed via a first transversal guidance actuator controlled by means of a driver-operated steering handle. Through the second channel, a vehicle system sets a target roll angle, and a second transversal guidance actuator is controlled by a transversal guidance system that performs a transversal guidance intervention based on the roll angle. The vehicle system displays the roll angle as a notification to the driver of the transversal guidance intervention. The invention also relates to a motor vehicle configured to perform the method.

Abstract: A housing for a high-frequency chip in a radar device for level measurement is provided, including a high-frequency chip having a high-frequency terminal and a supply terminal; horizontal metal layers; vertical metal connecting lines; and an external supply terminal configured to connect the chip to a circuit board of the device, the chip being attached to one of the horizontal metal layers in an electrically conductive manner, and being embedded in a polymer compound, which is located between the horizontal metal layers, the supply terminal being connected to the external supply terminal via at least one of the horizontal metal layers and via at least one of the vertical metal connecting lines, and the high-frequency terminal being connected to an antenna configured to decouple and receive radar waves, via at least one of the horizontal metal layers and/or via at least one of the vertical metal connections.

Abstract: The present disclosure relates to tumour therapy. In one aspect, the present disclosure relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: A level radar is switchable between pulsed and FMCW radar methods. For example, the radar device may include two separate front ends which can be activated selectively via a logic control system. Upon switching to the respective other measurement principle, the evaluation software is also adapted accordingly. In this way, it is possible to use advantageous properties of both measurement methods in a targeted manner.

Abstract: The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer and other disorders and diseases. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues.