Patents by Inventor Christoph Spiess

Christoph Spiess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific antibodies binding to beta-klotho and fibroblast growth factor receptor 1
    Patent number: 9873748
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: January 23, 2018
    Assignee: GENENTECH, INC.
    Inventors: Yongmei Chen, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • ANTI-IL-13/IL-17 BISPECIFIC ANTIBODIES AND USES THEREOF
    Publication number: 20170334985
    Abstract: The invention provides anti-IL-13/IL-17 bispecific antibodies, in particular, anti-IL13/IL17 AA, AF and FF antibodies and methods of using the same, including without limitation, methods of using the anti-IL-13/IL-17 bispecific antibodies for treating moderate to severe asthma and/or eosinophilic asthma.
    Type: Application
    Filed: February 23, 2017
    Publication date: November 23, 2017
    Applicant: Genentech, Inc.
    Inventors: LAWREN WU, JOSEPH R. ARRON, MICHAEL DILLON, DAVID F. CHOY, SUE SOHN, CHRISTOPH SPIESS, WHITNEY SHATZ
  • Production of heteromultimeric proteins
    Patent number: 9637557
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: May 2, 2017
    Assignee: Genentech, Inc.
    Inventors: Justin Scheer, Christoph Spiess, Daniel G. Yansura
  • HUMANIZED AND AFFINITY MATURED ANTIBODIES TO FcRH5 AND METHODS OF USE
    Publication number: 20160368985
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Application
    Filed: June 16, 2016
    Publication date: December 22, 2016
    Inventors: Isidro HOTZEL, Teemu T. JUNTTILA, Ji LI, Justin SCHEER, Danielle DICARA, Diego ELLERMAN, Christoph SPIESS, Paul J. CARTER
  • ANTIBODIES AND METHODS OF USE
    Publication number: 20160319038
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 3, 2016
    Applicant: GENENTECH, INC.
    Inventors: YONGMEI CHEN, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • ANTI-IL-4 ANTIBODIES AND BISPECIFIC ANTIBODIES AND USES THEREOF
    Publication number: 20160207995
    Abstract: The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.
    Type: Application
    Filed: September 18, 2015
    Publication date: July 21, 2016
    Applicant: GENENTECH, INC.
    Inventors: Daniel G. Yansura, Nancy Y. Chiang, Mark S. Dennis, Michael Dillon, Germaine G. Fuh, Gerald R. Nakamura, Christoph Spiess, Lawren C. Wu, Yin Zhang
  • ANTIBODIES AND METHODS OF USE
    Publication number: 20150218276
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Application
    Filed: December 23, 2014
    Publication date: August 6, 2015
    Applicant: GENENTECH, INC.
    Inventors: Yongmei Chen, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • Production of Heteromultimeric Proteins
    Publication number: 20110287009
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
    Type: Application
    Filed: April 22, 2011
    Publication date: November 24, 2011
    Applicant: Genentech, Inc.
    Inventors: Justin Scheer, Christoph Spiess, Daniel G. Yansura