Patents by Inventor Christophe Carola

Christophe Carola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080038213
    Abstract: The invention relates to compounds of the formula (I) or (II), to compositions which comprise such compounds, to corresponding processes for the preparation of the compounds or the compositions comprising same, and to the use thereof as light-protection filters.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 14, 2008
    Applicant: MERCK PATENT GMBH
    Inventors: Christophe Carola, Frank Pfluecker, Herwig Buchholz, Hansjurgen Driller, Hans Neunhoeffer, Evgeniy Blyumin
  • Publication number: 20080027133
    Abstract: The invention relates to the use of chromen-4-one derivatives of the formula I where R1 and R2 may be identical or different and are selected from H, —C(?O)—R7, —C(?O)—OR7, alkyl groups, alkenyl groups, hydroxyalkyl groups and/or cycloalkyl groups and/or cycloalkenyl groups, R3 is H or alkyl groups, R4 is H or OR8, R5 and R6 are selected from —H, —OH, alkyl groups, alkenyl groups and hydroxyalkyl groups, and R7 is H, alkyl groups, a polyhydroxyl compound, such as, preferably, an ascorbic acid radical or glycosidic radicals, and R8 is H or alkyl groups, where at least two of the substituents R1, R2 and R4-R6 are different from H or at least one substituent from R1 and R2 is —C(?O)—R7 or —C(?O)—OR7, for the care, preservation or improvement of the general state of the skin or hair.
    Type: Application
    Filed: October 9, 2007
    Publication date: January 31, 2008
    Inventors: Christophe Carola, Herwig Buchholz, Sylvia Huber, Ralf Rosskopf
  • Patent number: 7307100
    Abstract: Novel compounds of the formula I in which R, X, n and m are as defined herein are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: December 11, 2007
    Assignee: Merck Patent GmbH
    Inventors: Teresa Mujica-Fernaud, Herwig Buchholz, Christophe Carola, Wilfried Rautenberg, Christian Sirrenberg
  • Publication number: 20070191305
    Abstract: The invention relates to complexes of certain chromone derivatives, to compositions which comprise such derivatives, to corresponding processes for the preparation of the chromone derivatives or of compositions comprising same, and to the use thereof, in particular for the care, maintenance or improvement of the general state of the skin or hair.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 16, 2007
    Inventors: Christophe Carola, Ralf Rosskopf, Herwig Buchholz
  • Publication number: 20070134172
    Abstract: The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative or extract.
    Type: Application
    Filed: November 5, 2004
    Publication date: June 14, 2007
    Inventors: Herwig Buchholz, Corinna Wirth, Christophe Carola, Rosane Alves Fontes
  • Publication number: 20060292093
    Abstract: The invention relates to compounds that are selected from the compounds of formulas (Ia)-(Ic) and to their production and use in cosmetic and dermatological products.
    Type: Application
    Filed: July 19, 2004
    Publication date: December 28, 2006
    Inventors: Christophe Carola, Herwig Buchholz
  • Patent number: 7128900
    Abstract: The invention relates to a preparation having light-protection properties comprising at least one compound of the formula I where R1 and R2 are selected from H and OR11, where each OR11, independently of the others, is OH, a straight-chain or branched C1- to C20-alkoxy group, a straight-chain or branched C3- to C20-alkenyloxy group, a straight-chain or branched C1- to C20-hydroxyalkoxy group, where the hydroxyl group(s) may be bonded to a primary or secondary carbon atom in the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or a C3- to C10-cycloalkoxy group and/or C3- to C12-cyclo-alkenyloxy group, where the rings may each also be bridged by —(CH2)n— groups, where n=1 to 3, and/or a mono- and/or oligoglycosyl radical, with the proviso that at least one radical from R1 and R2 is OR11, and R3 is a radical OR11, and R4 to R7 and R10 may be identical or different and are, independently of one another, radicals which are substantially inert with respect to the UV properties.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: October 31, 2006
    Assignee: Merck Patent GmbH
    Inventors: Herwig Buchholz, Christophe Carola, Sophie Perruchon
  • Publication number: 20060045856
    Abstract: The invention relates to a cosmetic or dermatological composition containing at least one precursor of a substance whose active form is sought for its cosmetic activity. One of the applications of the invention relates to compositions capable of rapidly imparting to the skin a color similar to that obtained on prolonged exposure to ultraviolet, solar or artificial radiation, while at the same time avoiding the drawbacks of such an exposure (erythema, burning, loss of elasticity, appearance of wrinkles, premature ageing of the skin, and the like).
    Type: Application
    Filed: September 1, 2004
    Publication date: March 2, 2006
    Inventors: Teresa Mujica, Christophe Carola, Sylvia Huber, Herwig Buchholz
  • Publication number: 20060039937
    Abstract: The invention relates to a composition having antioxidant properties comprising at least one compound of the formula I or a cosmetically, dermatologically or pharmacologically tolerated salt or derivative thereof where R1 to R4 can be identical or different and are selected from H C6-28-alkylcarboxylic acid radicals C6-28-alkenylcarboxylic acid radicals radicals of the formula II where R5-R8, independently of one another, are H, hydroxyl or C1-6-alkoxy, with the proviso that at least one of the radicals R1 to R4 is a radical of the formula II.
    Type: Application
    Filed: October 29, 2004
    Publication date: February 23, 2006
    Inventors: Teresa Mujica-Fernaudd, Christophe Carola, Marcus Brunner, Sylvia Huber, Herwig Buchholz
  • Publication number: 20050043398
    Abstract: The invention relates to the use of chrome-4-one derivatives of the formula I where R1 and R2 may be identical or different and are selected from H, —C(?O)—R7, —C(?O)—OR7, alkyl groups, alkenyl groups, hydroxyalkyl groups and/or cycloalkyl groups and/or cycloalkenyl groups, R3 is H or alkyl groups, R4 is H or OR8, R5 and R6 are selected from —H, —OH, alkyl groups, alkenyl groups and hydroxyalkyl groups, and R7 is H, alkyl groups, a polyhydroxyl compound, such as, preferably, an ascorbic acid radical or glycosidic radicals, and R8 is H or alkyl groups, where at least two of the substituents R1, R2 and R4—R6 are different from H or at least one substituent from R1 and R2 is —C(?O)—R7 or —C(?O)—OR7, for the care, preservation or improvement of the general state of the skin or hair.
    Type: Application
    Filed: August 18, 2004
    Publication date: February 24, 2005
    Inventors: Christophe Carola, Herwig Buchholz, Sylvia Huber, Ralf Rosskopf
  • Publication number: 20040176440
    Abstract: Novel compounds of the formula I 1
    Type: Application
    Filed: December 2, 2003
    Publication date: September 9, 2004
    Inventors: Teresa Mujica-Fernaud, Herwig Buchholz, Christophe Carola, Wilfried Rautenberg, Christian Sirrenberg
  • Publication number: 20040138464
    Abstract: Novel compounds of the formula I 1
    Type: Application
    Filed: December 2, 2003
    Publication date: July 15, 2004
    Inventors: Teresa Mujica-Fernaud, Herwig Buchholz, Christophe Carola, Wilfried Rautenberg, Christian Sirrenberg
  • Publication number: 20040091433
    Abstract: The invention relates to a preparation having light-protection properties comprising at least one compound of the formula I 1
    Type: Application
    Filed: July 18, 2003
    Publication date: May 13, 2004
    Applicant: Merck Patent GmbH
    Inventors: Herwig Buchholz, Christophe Carola, Sophie Perruchon
  • Publication number: 20040081675
    Abstract: The invention relates to cosmetic formulations, pharmaceutical preparations, food products and food supplements containing flavonoid derivatives. The flavonoid derivatives act therein, for instance, as UV filter. Some flavonoid derivatives represent novel compounds.
    Type: Application
    Filed: August 21, 2003
    Publication date: April 29, 2004
    Inventors: Corinna Wirth, Herwig Buccholz, Christophe Carola
  • Publication number: 20040067894
    Abstract: The invention relates to a preparation having antioxidant properties, comprising at least one compound of the formula I 1
    Type: Application
    Filed: September 23, 2003
    Publication date: April 8, 2004
    Applicant: Merck Patent GmbH
    Inventors: Christophe Carola, Sophie Perruchon, Herwig Buchholz
  • Patent number: 6096724
    Abstract: The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof,R.sup.2 is selected from H, C.sub.1 -C.sub.5 alkyl, halogen or NH.sub.2,R.sup.4 and R.sup.5 which are the same or different are selected from H, NH.sub.2 or NO.sub.n where n=1 or 2, or R.sup.4 and R.sup.5 together with the pyrimidine ring form a 5- or 6-membered ring structure containing one or more heterocyclic atoms, and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: August 1, 2000
    Assignee: Cancer Research Campaign Technology Limited
    Inventors: Thomas Brian Hamilton McMurry, Robert Stanley McElhinney, Joan Elizabeth McCormick, Dorothy Josephine Donnelly, Paul Murray, Christophe Carola, Rhoderick Hugh Elder, Jane Kelly, Geoffrey Paul Margison, Amanda Jean Watson, Joseph Anthony Rafferty, Mark Andrew Willington, Mark Ross Middleton
  • Patent number: 5929046
    Abstract: The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof,R.sup.2 is selected from H, C.sub.1 -C.sub.5 alkyl, halogen or NH.sub.2,R.sup.4 and R.sup.5 which are the same or different are selected fromH, NH.sub.2 or NO.sub.n where n=1 or 2, or R.sup.4 and R.sup.5 together with the pyrimidine ring form a 5-or 6-membered ring structure containing one or more heterocyclic atoms, and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity.
    Type: Grant
    Filed: December 15, 1995
    Date of Patent: July 27, 1999
    Assignee: Cancer Research Campaign Technology Limited
    Inventors: Thomas Brian Hamilton McMurry, Robert Stanley McElhinney, Dorothy Josephine Donnelly, Paul Murray, Christophe Carola, Rhoderick Hugh Elder, Jane Kelly, Geoffrey Paul Margison, Joseph Anthony Rafferty, Amanda Jean Watson, Mark Andrew Willington