Abstract: The invention relates to pharmaceutical compounds of formula (I) and pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as inhibitors of cyclin-dependent kinase 7 (CDK7) and to their use in the treatment of diseases, e.g. cancer.

Abstract: A system installed in a cross-border area between a provider network of a provider and a customer network of a customer includes: a smart optical network termination device (NT) at a site of the customer, wherein the smart optical NT is configured to implement a demarcation point between the customer network and the provider network, and wherein the smart optical NT is independent of a data rate passing through it and an optical interface connected to it; and a monitoring device located at a point of presence (PoP) of the provider network. The smart optical NT is further configured to monitor a coupling of optical power by the customer into the provider network and to interact with the monitoring device via at least one traffic analysis point (TAP) for connectivity validation from the PoP to the demarcation point.

Abstract: An apparatus for management of a spectral capacity of a wavelength division multiplexing, WDM, system includes at least one pair of transmission fibers provided for transporting optical signals. Each transmission fiber of a transmission fiber pair is connected to a first port of an optical circulator having at least two additional ports and adapted to transmit an incoming optical signal entering one of its ports via its next port. WDM subsystems configured with counter-propagating assignable wavelengths are connected to associated ports of the optical circulator of the apparatus.

Abstract: Technology for guiding a user to collect clinically usable ultrasound images is described. In some embodiments, an ultrasound device may automatically change the elevational steering angle of its ultrasound beam (e.g., using beamforming) in order to collect ultrasound data from different imaging planes within the subject. A processing device in operative communication with the ultrasound device may select one of the collected ultrasound images based on its quality (e.g., select the ultrasound image having the highest quality), and then continue to collect ultrasound images using the elevational steering angle at which the selected ultrasound image was collected.

Abstract: Aspects of the technology described herein relate to configuring an ultrasound system with imaging parameter values. In particular, certain aspects relate to configuring an ultrasound system to produce a plurality of sets of ultrasound images, each respective set of the plurality of sets of ultrasound images being produced with a different respective set of a plurality of sets of imaging parameter values; obtaining, from the ultrasound system, the plurality of sets of ultrasound images; determining a set of ultrasound images from among the plurality of sets of ultrasound images that has a highest quality; and based on determining the set of ultrasound images from among the plurality of sets of ultrasound images that has the highest quality, automatically configuring the ultrasound system to produce ultrasound images using a set of imaging parameter values with which the set of ultrasound images that has the highest quality was produced.

Abstract: The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The invention relates to a method for migrating data traffic from an existing optical WDM transmission system to a new optical WDM transmission system, the existing optical WDM transmission system using a first optical transmission band and the new optical WDM transmission system being capable of using a second optical transmission band. The second optical transmission band at least partially includes the first optical transmission band and a further extension band that does not overlap with the first optical transmission band, the method including the steps of. According to the invention, a migration filter device is used in order to connect, during a migration phase, the network nodes of the existing system and the network nodes of the new system to the network paths that have been used by the existing system. During the migration phase, both systems are operated in parallel, with the new system using the extension band only.

Abstract: The invention relates to a method for migrating data traffic from an existing optical WDM transmission system to a new optical WDM transmission system, the existing optical WDM transmission system using a first optical transmission band and the new optical WDM transmission system being capable of using a second optical transmission band. The second optical transmission band at least partially includes the first optical transmission band and a further extension band that does not overlap with the first optical transmission band, the method including the steps of. According to the invention, a migration filter device is used in order to connect, during a migration phase, the network nodes of the existing system and the network nodes of the new system to the network paths that have been used by the existing system. During the migration phase, both systems are operated in parallel, with the new system using the extension band only.

Abstract: An apparatus for management of a spectral capacity of a wavelength division multiplexing, WDM, system includes at least one pair of transmission fibers provided for transporting optical signals. Each transmission fiber of a transmission fiber pair is connected to a first port of an optical circulator having at least two additional ports and adapted to transmit an incoming optical signal entering one of its ports via its next port. WDM subsystems configured with counter-propagating assignable wavelengths are connected to associated ports of the optical circulator of the apparatus.

Abstract: The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Aspects of the technology described herein relate to automatically calculating an ultrasound pulse transmission direction and configuring an ultrasound device to transmit ultrasound pulses along the ultrasound pulse transmission direction for pulsed wave Doppler ultrasound imaging. Automatically calculating the ultrasound pulse transmission direction may be based on a selected sample volume within a subject where flow velocity is to be measured with the pulsed wave Doppler ultrasound imaging, and a selected direction of the flow velocity to be measured with the pulsed wave Doppler ultrasound imaging.

Abstract: A compound that has retinol like properties is used in compositions for treating the skin.

Abstract: The present invention relates to bicyclic pyridine, pyrazine, and pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Aspects of the technology described herein include a processing device configured to display, on a touch-sensitive display screen of a processing device in operative communication with an ultrasound device, an ultrasound image, a target region identifier superimposed on the ultrasound image, a first icon located on the target region identifier, and a second icon located on the target region identifier. The first icon is configured to control the height of the target region identifier and the angle of two opposite sides of the target region identifier. The second icon is configured to control the width of the target region identifier. The processing device is configured to configure the ultrasound device to collect color Doppler ultrasound data based on the region of the ultrasound image covered by the target region identifier and the angle of the two opposite sides of the target region identifier.

Abstract: Aspects of the technology described herein include ultrasound data collection using different image formats. Some embodiments include causing, within a single imaging preset, an ultrasound device having a single transducer array to switch from a configuration to collect ultrasound data for producing ultrasound images having a first format to a configuration to collect ultrasound data for producing ultrasound images having a second format. Some embodiments include modulating, within a single imaging preset and as a function of imaging depth, a virtual apex location and/or an instantaneous transmit aperture size used for ultrasound data collection by an ultrasound device having a single transducer array.

Abstract: The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: A method is provided for determining a personalized cardiac model, including steps of (i) computing a velocity time profile of a blood flow across a selected area of the heart or the aorta during at least one cardiac cycle, using data acquired with a Magnetic Resonance Imaging (MRI) device; (ii) performing a segmentation of the velocity time profile so as to identify cardiac phases according to a predefined generic cardiac model; and (iii) computing normalized time location and/or duration of the cardiac phases within cardiac cycles so as to define a personalized cardiac model.

Abstract: The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Aspects of the technology described herein relate to configuring an ultrasound system with imaging parameter values. In particular, certain aspects relate to configuring an ultrasound system to produce a plurality of sets of ultrasound images, each respective set of the plurality of sets of ultrasound images being produced with a different respective set of a plurality of sets of imaging parameter values; obtaining, from the ultrasound system, the plurality of sets of ultrasound images; determining a set of ultrasound images from among the plurality of sets of ultrasound images that has a highest quality; and based on determining the set of ultrasound images from among the plurality of sets of ultrasound images that has the highest quality, automatically configuring the ultrasound system to produce ultrasound images using a set of imaging parameter values with which the set of ultrasound images that has the highest quality was produced.