Abstract: A wavelength division multiplexed telecommunication system with automatic compensation of chromatic dispersion in a predetermined wavelength band, said WDM telecommunication system comprising a probe signal detection unit at a receiver side adapted to detect amplitude modulated probe signals generated by a probe signal generation unit at a transmitter side with a predetermined relative phase difference and transmitted through an optical link to said receiver side; and a chromatic dispersion compensation unit adapted to compensate the chromatic dispersion in response to a relative phase difference of the amplitude modulated probe signals detected by said probe signal detection unit at the receiver side.

Abstract: The present invention relates to azabenzimidazole derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to bicyclic pyridine, pyrazine, and pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Aspects of the technology described herein relate to configuring an ultrasound device with ultrasound imaging presets. Some embodiments include configuring an ultrasound device with different sets of imaging parameter values without receiving user input regarding configuration of the ultrasound device between configuration of the ultrasound device with one set of imaging parameter values and configuration of the ultrasound device with another set of imaging parameter values. Some embodiments include automatically configuring an ultrasound device with a set of imaging parameter values based on automatically determining an anatomical location being imaged by the ultrasound device. Some embodiments include automatically configuring an ultrasound device with a cardiac preset when a cardiac region is being imaged and automatically configuring the ultrasound device with an abdominal preset when an abdominal region is being imaged during a FAST or eFAST exam.

Abstract: A compound that has retinol like properties is used in compositions for treating the skin.

Abstract: The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to heterocyclyl linked imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related discorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L1, a, b, m, n, R1, R2, R3, R4, and R5 are defined herein.

Abstract: A chromatic dispersion compensation apparatus for automatic compensation of chromatic dispersion of signals transmitted via an optical link at predetermined wavelengths of WDM channels within a predetermined band. A tapping unit taps optical signals received by the chromatic dispersion compensation apparatus via the optical link at predetermined wavelengths and supply them to an optical coherent receiver adapted to tune its local oscillator to WDM channels to generate corresponding analog electrical signals of the WDM channels which are sampled by an analog digital converter to provide digital signal samples of WDM channels processed by a digital signal processor of the chromatic dispersion compensation apparatus to calculate an estimate residual chromatic dispersion value of the received optical signals.

Abstract: The present invention relates to substituted imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related discorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L1, a, b, m, n, R1, R2, R3, R4, and R5 are defined herein.

Abstract: A chromatic dispersion compensation apparatus for automatic compensation of chromatic dispersion of signals transmitted via an optical link at predetermined wavelengths of WDM channels within a predetermined band. A tapping unit taps optical signals received by the chromatic dispersion compensation apparatus via the optical link at predetermined wavelengths and supply them to an optical coherent receiver adapted to tune its local oscillator to WDM channels to generate corresponding analog electrical signals of the WDM channels which are sampled by an analog digital converter to provide digital signal samples of WDM channels processed by a digital signal processor of the chromatic dispersion compensation apparatus to calculate an estimate residual chromatic dispersion value of the received optical signals.

Abstract: The present invention relates to heterocyclyl linked imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to substituted imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: A wavelength division multiplexed telecommunication system with automatic compensation of chromatic dispersion in a predetermined wavelength band, said WDM telecommunication system comprising a probe signal detection unit at a receiver side adapted to detect amplitude modulated probe signals generated by a probe signal generation unit at a transmitter side with a predetermined relative phase difference and transmitted through an optical link to said receiver side; and a chromatic dispersion compensation unit adapted to compensate the chromatic dispersion in response to a relative phase difference of the amplitude modulated probe signals detected by said probe signal detection unit at the receiver side.

Abstract: The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.

Abstract: Cyclopropylboronic compounds, the preparation process thereof and the use thereof.

Abstract: A method is provided for determining a personalized cardiac model, including steps of (i) computing a velocity time profile of a blood flow across a selected area of the heart or the aorta during at least one cardiac cycle, using data acquired with a Magnetic Resonance Imaging (MRI) device; (ii) performing a segmentation of the velocity time profile so as to identify cardiac phases according to a predefined generic cardiac model; and (iii) computing normalized time location and/or duration of the cardiac phases within cardiac cycles so as to define a personalized cardiac model.

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related discorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L1, a, b, m, n, R1, R2, R3, R4, and R5 are defined herein.

Abstract: The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.