Abstract: A gate valve includes a pair of opposing housing members, a gate, primary sealing sleeves and a secondary sealing member. The primary sealing sleeves are disposed in each of the housing members. The gate is configured to slidably pass through a transverse gate chamber defined when the housing members are joined together. The secondary sealing member is secured between the housing members and includes at least one passage or aperture configured to allow lubricating fluid to be applied through at least one of the housing members through the secondary sealing member and onto the gate.

Abstract: Disclosed herein are fibers comprising an active material that assists in removing contaminants from fluid. The active material, which forms a coating on the fiber, typically comprises a non-fibrous: nanostructured, metal-containing compound, such as a metal-oxygen compound. A filter media made of such fibers, as well as methods of making the fiber and the filter media are also disclosed. Methods of purifying fluids, such as air, water, and fuels, are further disclosed.

Abstract: Disclosed herein is a nanostructured material comprising defective carbon nanotubes chosen from impregnated, functionalized, doped, charged, coated, and irradiated nanotubes, and combinations thereof. The defective carbon nanotubes contain a defect which is a lattice distortion in at least one carbon ring. Also disclosed is a method of purifying fluids, such as liquids, including water, as well as gases, including the air using, this nanostructured material.

Abstract: Disclosed herein is a method of generating hydrogen that comprises forming a mixture of a hydrogen containing compound and a nanotube containing material, and dissociating hydrogen by exposing the mixture to activation energy. Also disclosed are articles for generating hydrogen comprising a container for holding the hydrogen containing compound and nanotube containing material, optionally comprising at least one inlet for applying activation energy.

Abstract: Disclosed herein is a nanostructured material comprising defective carbon nanotubes chosen from impregnated, functionalized, doped, charged, coated, and irradiated nanotubes, and combinations thereof. The defective carbon nanotubes contain a defect which is a lattice distortion in at least one carbon ring. Also disclosed is a method of purifying fluids, such as liquids, including water, as well as gases, including the air using, this nanostructured material.

Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L, R3, R3a, R3b and R4 are defined herein.

Abstract: A method of preparing a molded cross vehicle beam which includes a hollow blow molded thermoplastic rigid member that is integrally attached to a rigid support, e.g., a U-shaped metal plate, and at least one attachment element, is described. The rigid support (12) has a first surface, a second surface and a plurality of perforations having edges. The attachment element(s) (81, 84) have a first surface, a second surface and a plurality of perforations having edges. The attachment element provides a means of attaching the molded cross vehicle beam to a separate structure (e.g., the A-pillars of an automobile). A thermoplastic parison precursor of the hollow rigid thermoplastic member (15) is blow molded against the first surfaces of the rigid support (12) and the attachment element (81, 84).

Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein G, L, Q, Z, R6, R7, and R8 are defined herein.

Abstract: A method of preparing a molded article by means of an in-mold decoration process, is described. The method includes, providing a laminate (4) of a plurality of separate releasable thermoplastic labels (14) superposed over a carrier film (26). A decoration (86) is applied in-line to the exposed second surface (68) of the labels (14), thereby forming a decorated laminate (5). The decorated laminate (5) is forwarded and indexed into a mold (20) such that the exposed first surface (77) of the carrier film (26) abuts at least a portion of the interior surface of the mold, and the decorated second surface (68) of the label (14) faces the interior space of the mold. Plastic material (e.g., thermoplastic material) is injected into the mold against the decorated surface of the label, thus forming a molded article. The carrier film (26) is then separated from the molded article.

Abstract: The invention provides compounds of formula 1 wherein R1, R2, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating and preventing diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission.

Abstract: The present invention relates to a method of preparing a coated molded article (59) by means of in-mold coating. The method involves the use of a mold apparatus (1) that includes a rotatable core (29) having at least one molding surface (32, 35), a first die (11) and a second die (17) each having an internal surface (14, 20) and each of which are reversibly engageable with the rotatable core. The second die (17) has a reversibly slidable portion (23) having an internal surface (26) that defines substantially the internal surface (20) of the second die (17). The internal surface (14) of the first die (11) and a molding surface (32) of the rotatable core together define a first mold cavity (38) in which a molded plastic article (44) is formed. The mold apparatus is opened, the core (29) is rotated to align the molded plastic article (44) with the internal surface (20) of the second die (17).

Abstract: A gate valve having a polymeric monolithic liner, the liner having cylindrical flange portions projecting from either side to form a fluid passageway through the liner, first and second housing portions forming a liner cavity, the liner being disposed in the liner cavity, a first face ring having a first cylindrical tubular portion and a first radially outwardly projecting, annularly extending face ring flange, the first tubular portion being received in the first annular flange portion of the liner, a second face ring having a second cylindrical tubular portion and a second radially outwardly projecting, annularly extending face ring flange, the second tubular portion being received in the second annular flange portion and a gate valve element slidably received in a valve element cavity formed in the liner.

Abstract: The power supply selection control circuit includes: a first comparator; a second comparator; a first reference generator coupled to a first power supply node, and having a first reference output node coupled to a first input of the first comparator and to a first input of the second comparator; and a second reference generator coupled to a second power supply node, and having a second reference output node coupled to a second input of the first comparator and to a second input of the second comparator. The first comparator provides a logic low when the first power supply voltage is lower than the second power supply voltage. The second comparator provides a logic low when the second power supply voltage is lower than the first power supply voltage.

Abstract: Disclosed herein is a material for altering electromagnetic radiation incident on the material. The material disclosed herein comprises carbon nanotubes having a length (L) that meets the following formula (1): L?½???(1) where ? is the wavelength of the electromagnetic radiation incident on the material. Also disclosed herein are methods of altering electromagnetic radiation, including mitigating, intensifying, or absorbing and re-transmitting electromagnetic radiation using the disclosed material.

Abstract: Disclosed herein are articles for removing contaminants from a fluid, such as a liquid or gas, the article comprising carbon nanotubes, which comprise at least one molecule or cluster attached thereto or located therein, wherein the carbon nanotubes are present in the article in an amount sufficient to reduce the concentration of contaminants in fluid that come into contact with the article. A method of making the nanomesh material used in such articles is also disclosed, as are methods of purifying fluids using these articles.

Abstract: A cutoff saw assembly incorporates a robot assembly with a compliant cutting apparatus to remove various undesired metal extensions from a casting. The assembly cooperatively and conjunctively controls the position of the casting using the robot assembly and the force exerted by the cutting apparatus on the casting using a compliance control system. The compliance control system includes a compliance actuator that is connected to a compliance regulator. Both the robot assembly and the compliance control system are connected to a system controller. The compliance actuator is connected to the cutoff blade to actively vary the force of the cutting blade with respect to the casting. The compliance regulator, which is connected to the system controller, will measure and regulate the pressure in the compliance actuator, such that the robot assembly and compliance control system can apply the required force to cut the casting.

Abstract: The invention provides novel modulatory polypeptides of TRAIL-induced apoptosis. The invention also provides methods for screening modulators of TRAIL-induced apoptosis. The methods comprise first screening test agents for modulators of a novel modulatory polypeptide of TRAIL-induced apoptosis and then further screening the identified modulating agents for modulators of TRAIL-induced apoptosis. The invention further provides methods and pharmaceutical compositions for modulating apoptosis of cells and for treating diseases and conditions such as cancers.

Abstract: A method of preparing a molded cross vehicle beam which includes a hollow blow molded thermoplastic rigid member that is integrally attached to a rigid support, e.g., a U-shaped metal plate, and at least one attachment element, is described. The rigid support (12) has a first surface, a second surface and a plurality of perforations having edges. The attachment element(s) (81, 84) have a first surface, a second surface and a plurality of perforations having edges. The attachment element provides a means of attaching the molded cross vehicle beam to a separate structure (e.g., the A-pillars of an automobile). A thermoplastic parison precursor of the hollow rigid thermoplastic member (15) is blow molded against the first surfaces of the rigid support (12) and the attachment element (81, 84).

Abstract: Trisubstituted heteroaromatic compounds having the structure are provided, wherein X is C or N; A and B are each independently CH or N, with the proviso that A and B cannot both be CH; R1 is Ar-L-; R2 is hydrogen or alkyl; or R1 and R2 can be joined together to form a 4- to 7-membered cycloheteroalkyl ring; R3 to R8, Ar and L are as defined herein. A method for using these compounds to treat diseases associated with abnormal bone or mineral homeostasis is also provided.

Abstract: A molded article comprising (a) a rigid support, e.g., a rigid seat support (10), having a plurality of perforations, and (b) a molded flexible hollow thermoplastic member (20), e.g., a flexible thermoplastic seat cushion, fixedly attached thereto is described. A portion of the flexible hollow member (b) extends through at least some of the perforations of the rigid support (a), embedding the edges of the perforations therein. The flexible material extending through the perforations forms an attachment means, e.g., an attachment head, that serves to fixedly attach the flexible hollow member (b) to the rigid support (a). Also described is a method of preparing the molded article of the present invention, in which the flexible hollow member (b) is fixedly attached to the rigid support (a) during the blow molding formation of hollow member (b).