Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: Methods and systems for producing vinyl acetate may use flammability limit (FL) formulas with improved efficiencies at more than one location in the vinyl acetate production process. Herein, FLs can be used at one or more of four portions of the vinyl acetate production process: the reactor, the process-to-process heat exchangers, the carbon dioxide removal system, and the ethylene recovery system. Such FLs are functions of operating conditions and include at least one interaction term that represents the interrelation of two or more of the operating conditions (e.g., temperature, pressure, and component concentration) on the FL.

Abstract: The invention relates to an electrosurgical apparatus for cutting and coagulating biological tissue. In particular, the present invention provides an electrosurgical generator arranged to generate radiofrequency (RF) electromagnetic (EM) energy and microwave frequency EM energy; wherein the electrosurgical generator is operable in each of a coagulation mode and a cutting mode, wherein in the coagulation mode the electrosurgical generator is arranged to deliver the RF EM energy and the microwave EM energy simultaneously in a coagulation composite waveform comprising a dominant microwave signal and a supplementary RF signal, and wherein in the cutting mode the electrosurgical generator is arranged to deliver the RF EM energy and the microwave EM energy simultaneously in a cutting composite waveform comprising a dominant RF signal and a supplementary microwave signal.

Abstract: An electrically grounded and corrosion-protected assembly includes a utility pole having a bottom portion that is buried in the earth. A water impermeable and electrically conductive cementitious surround is applied to at least a section of the portion that is buried in the earth. The surround is in direct contact with the section and is between the section and the earth. A brace is embedded in the surround and supports the utility pole. The brace may include an aggregate such as gravel.

Abstract: The invention relates to sterilisation systems suitable for clinical use, e.g. on the human body, medical apparatuses, or hospital bed spaces. In particular, the invention provides a sterilisation apparatus comprising: a sterilisation device having a hydroxyl radical generating region and an outlet for directing generated hydroxyl radicals out of the hydroxyl radical generating region towards a region to be sterilised; and a steam supply connected to deliver dry steam to the sterilisation device, wherein the sterilisation device is configured to generate a high impedance at the hydroxyl radical generating region when dry steam, radiofrequency (RF) and/or microwave frequency electromagnetic (EM) energy, and gas are delivered to the hydroxyl generating region, thereby to create a plasma of the gas which forms an ionisation discharge for generating hydroxyl radicals from the dry steam for delivery out of the hydroxyl generating region.

Abstract: Embodiments provide a filter with a generally rectangular, non-cylindrical profile. The filter may have multiple pleat packs positioned between pleat covers that define regions and flow channels in a cavity of the filter body. The pleat covers have openings that allow a fluid to flow through the multiple pleat packs via parallel flows or series flows. End caps bonded to the body define flow passages for directing the fluid from an inlet to an outlet via the pleat packs for series or parallel filtration. The pleat packs may be made of the same or different materials and may be configured with the same or different heights based on flow requirements. A cage or a separator may be positioned between the pleat packs. The pleat packs may be made of a continuous pleated membrane with bridges defining a space between the pleat packs to accommodate the cage or separator.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for learning visual concepts using neural networks. One of the methods includes receiving a new symbol input comprising one or more symbols from a vocabulary; and generating a new output image that depicts concepts referred to by the new symbol input, comprising: processing the new symbol input using a symbol encoder neural network to generate a new symbol encoder output for the new symbol input; sampling, from the distribution parameterized by the new symbol encoder output, a respective value for each of a plurality of visual factors; and processing a new image decoder input comprising the respective values for the visual factors using an image decoder neural network to generate the new output image.

Abstract: A turbine nozzle assembly for use in a turbine engine is provided. The assembly includes an inner barrel and a turbine nozzle support ring. The inner barrel has a forward end and an aft end. The turbine nozzle support ring includes an annular body that defines a forward end, an opposite aft end, an inner surface, and an opposite outer portion. The forward end of the annular body is coupled to the aft end of the inner barrel. The annular body includes a first arcuate segment and a second arcuate segment removably coupled to the first arcuate segment. The first arcuate segment has a first arcuate length and the second arcuate segment has a second arcuate length. The second arcuate length is shorter than the first arcuate length.

Abstract: A cone and clamp assembly for a screen assembly comprises a substantially vertical supporting member about which a screen can be wound/unwound, a cone associated with at least one end of the supporting member and rotatable with the supporting member and at least one line member that can be wound onto and off the cone. The cone and clamp assembly comprises a clamp configured to hold the at least one line member relative to an external surface of the cone in an engaged position during transportation of the screen assembly or prior to operation of the screen assembly, a drive plate engaged with a pivot pin of the clamp, a cone plate coupled to the cone through the drive plate and the clamp, and an adjustable element coupled between the cone plate and the drive plate. Adjustment of the adjustable element in a first direction rotates the clamp toward the external surface of the cone and adjustment of the adjustable element in a second direction rotates the clamp away from the external surface of the cone.

Abstract: A robot-assisted surgical system in which apparatus for providing electrosurgical functionality is directly mountable on or integrated within a robotic arm. The apparatus may be a detachable module or capsule, which may be movable between different robotic arms in the same environment. The apparatus may comprise a plurality of modules, each providing a different treatment modality. Depending on the procedure to be performed, a different module or combination of modules may be selected and mounted on one or more robotic arms.

Abstract: An electrosurgical apparatus and method for performing thermal treatment in the gastrointestinal tract, e.g. to ablate duodenal mucosal tissue. The apparatus comprises an instrument having a flexible cable and an applicator suitable for use with a gastroscope, which can be deployed within a patient to delivery energy in a targeted or otherwise controllable manner. The applicator can deliver microwave energy by radiation. The direct and depth-limited nature of microwave energy can be make it more effective than treatments that rely on thermal conduction. The applicator may include a radially extendable portion arranged to move an microwave energy delivery structure into contact with duodenal mucosal tissue at the treatment region. The applicator may comprise any of a balloon, bipolar radiator, movable paddle, and rotatable roller element.

Abstract: One or more complex lipids including gangliosides to achieve particular health benefits including maintaining or increasing cognitive development or maintaining or increasing growth in a foetal, infant or child subject.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: A microstrip impedance transformer that permits efficient (i.e. low loss) coupling of a microwave feed line (e.g. a conventional 50? coaxial cable) to an instrument cable, where the instrument cable has a lower impedance (e.g. in the range 12 to 14?) and includes an internal passageway. The microstrip impedance transformer is configured to perform impedance matching between the microwave feed line and the instrument cable in a manner that does not adversely affect a separate feed, e.g. for delivering fluid, into the internal passageway.

Abstract: The disclosed apparatus may include a collar for charging a personal mobility vehicle via a dock. In some embodiments, the collar may be fitted with a charging connector that interfaces with a dock that charges the personal mobility vehicle when the personal mobility vehicle is docked. In one embodiment, the collar and a corresponding receiving element in the dock may be shaped such that the collar fits securely in the receiving element without requiring mechanical action by the collar or receiving element and only requiring a user to push the personal mobility vehicle straight into the dock. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: An electrical grounding assembly includes an electrically conductive metal grounding substrate that is electrically connectable to a structure to be electrically grounded. A corrosion-protective jacket is on the grounding substrate. The jacket is electrically conductive and water impermeable, and includes a polymeric matrix and a particulate carbonaceous material dispersed in the polymeric matrix.

Abstract: Aspects of the disclosure relate to generating a speed plan for an autonomous vehicle. As an example, the vehicle is maneuvered in an autonomous driving mode along a route using pre-stored map information. This information identifies a plurality of keep clear regions where the vehicle should not stop but can drive through in the autonomous driving mode. Each keep clear region of the plurality of keep clear regions is associated with a priority value. A subset of the plurality of keep clear regions is identified based on the route. A speed plan for stopping the vehicle is generated based on the priority values associated with the keep clear regions of the subset. The speed plan identifies a location for stopping the vehicle. The speed plan is used to stop the vehicle in the location.

Abstract: A method and apparatus are provided for optimizing one or more object detection parameters used by an autonomous vehicle to detect objects in images. The autonomous vehicle may capture the images using one or more sensors. The autonomous vehicle may then determine object labels and their corresponding object label parameters for the detected objects. The captured images and the object label parameters may be communicated to an object identification server. The object identification server may request that one or more reviewers identify objects in the captured images. The object identification server may then compare the identification of objects by reviewers with the identification of objects by the autonomous vehicle. Depending on the results of the comparison, the object identification server may recommend or perform the optimization of one or more of the object detection parameters.

Abstract: Determining an instantaneous vehicle characteristic (e.g., at least one yaw rate) of an additional vehicle that is in addition to a vehicle being autonomously controlled, and adapting autonomous control of the vehicle based on the determined instantaneous vehicle characteristic of the additional vehicle. For example, autonomous steering, acceleration, and/or deceleration of the vehicle can be adapted based on a determined instantaneous vehicle characteristic of the additional vehicle. In many implementations, the instantaneous vehicle characteristics of the additional vehicle are determined based on data from a phase coherent Light Detection and Ranging (LIDAR) component of the vehicle, such as a phase coherent LIDAR monopulse component and/or a frequency-modulated continuous wave (FMCW) LIDAR component.