Abstract: Disclosed herein are compositions and methods for oral delivery of nicotine and nicotine derivatives. In one embodiment the nicotine is delivered in an oral packets, pouches, or sachets.

Abstract: A multi-color LED display comprises pixels, each comprising a first sub-pixel, a second sub-pixel, and a third sub-pixel. The first sub-pixel comprises a first light-emitting diode (LED) that emits a first color of light, the second sub-pixel comprises second LEDs that emit a second color of light different from the first color of light, and the third sub-pixel comprises third LEDs that emit a third color of light different from the first color of light and different from the second color of light. The second LEDs are electrically connected in parallel and the third LEDs are electrically connected in series.

Abstract: A method of decoding video data by a device is provided. A merge subblock flag specifying whether subblock-based inter prediction parameters for a coding unit are inferred from neighbouring blocks is decoded. A motion vector difference merge flag is decoded if a value of the merge subblock flag is equal to zero and a value of a motion vector difference flag is equal to one. The motion vector difference merge flag specifies a prediction parameter with a motion vector difference is used, and the motion vector difference flag specifies whether a merge mode with motion vector difference is enabled.

Abstract: A pixel with a color-agnostic repair site includes a pixel controller, a first site for a first light emitter electrically connected to the pixel controller with a first wire, a second site for a second light emitter electrically connected to the pixel controller with a second wire different from the first wire, and a repair site for a repair light emitter. A repair wire can independently electrically connect the repair site to the pixel controller. A repair wire can electrically connect the repair site to the first wire or to the second wire with a jumper. The repair site can electrically connect to the first wire or to the second wire. A first repair wire can electrically connect the repair site to the first wire, a second repair wire can electrically connect the repair site to the second wire, and one of these wires can be cut.

Abstract: The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis: Formula (I), Formula (II).

Abstract: Systems and methods for securely exposing context-driven services within a web browser. An example method includes receiving manifests from hubs apps (e.g., remote services). The manifests define requested context types for the hub apps. When the web browser loads a web page, the web browser may execute context extractors to extract context from the web page. The context extractors that are executed are based on the context types requested by the hub apps. The extracted context is then sent to the corresponding hub apps without providing the hub apps direct access to the web page. For instance, the hub apps do not have access to the document object model (DOM) of the web page and the hub apps cannot inject data into the web page.

Abstract: A system allows the identification and protection of sensitive data in a multiple ways, which can be combined for different workflows, data situations or use cases. The system scans datasets to identify sensitive data or identifying datasets, and to enable the anonymisation of sensitive or identifying datasets by processing that data to produce a safe copy. Furthermore, the system prevents access to a raw dataset. The system enables privacy preserving aggregate queries and computations. The system uses differentially private algorithms to reduce or prevent the risk of identification or disclosure of sensitive information. The system scales to big data and is implemented in a way that supports parallel execution on a distributed compute cluster.

Abstract: A device source wafer includes a wafer substrate, devices formed on or in the wafer substrate at a location on the wafer substrate, and test structures disposed on the wafer substrate connected to some but not all of the devices. The devices include a first device disposed at a first location and a second device disposed at a second different location on the wafer substrate. The test structures include at least a first test structure connected to the first device and a second test structure connected to the second device. The first test structure is adapted to measuring a characteristic of the first device and the second test structure is adapted to measuring the characteristic of the second device. An estimated characteristic of unmeasured devices is derived from the first and second device locations and measured characteristics and the device is selected based on the estimated characteristic.

Abstract: An email system detects a user interaction to interact with a social media application, within the email system. The email system accesses a social media component that renders a user interface from the social media system and detects interactions with the user interface to generate content for the social media application. The social media component calls the social media application, with the content, and provides a response indicating that the content has been sent to the social media application.

Abstract: A device may be configured to signal scaling window information according to one or more of the techniques described herein.

Abstract: A video coding device may be configured to perform transform data coding according to one or more of the techniques described herein.

Abstract: An aerodynamic bicycle rim comprising: a circumferential outer portion comprising a circumferential outer surface, the circumferential outer portion adapted to seat a bicycle tire; a nose; and a set of sidewalls, each sidewall extending radially from the nose of the aerodynamic bicycle rim to a corresponding transition to the circumferential outer surface to form a rim body having a maximum rim body width that is greater than a maximum width of the bicycle tire. The aerodynamic bicycle rim is operable to seat the bicycle tire so that the aerodynamic bicycle rim and the bicycle tire form an asymmetrical cross-sectional shape.

Abstract: Some embodiments provide a method of decoding a current video block in a video picture. From several partitioning schemes, the method identifies a partitioning scheme that is used to partition the current video block. Based on the identified partitioning scheme, the method selects one derivation to compute a first quantization parameter for the current video block from several candidate derivations for computing the first quantization parameter. The method computes a second quantization parameter for the current video block based at least in part on the computed first quantization parameter. The method then uses the computed second quantization parameter to decode the current video block.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Examples are disclosed that relate to efficient computer-storage and computer-rendering of obstacle data in the computer-generated map view. In one example, one or more vector tiles collectively representing a geographic region are received. Each of the one or more vector tiles represents a sub-region of the geographic region. Obstacle data for one or more obstacles in the geographic region is received. The obstacle data defines a location of each of the one or more obstacles in relation to a local origin of the vector tile representing the sub-region where the obstacle is geographically located. A map view is rendered for visual presentation via a display. The map view includes the geographic region represented by the one or more vector tiles and indicating the one or more obstacles.

Abstract: Systems and methods which facilitate fixed rate shipping through the use of perpetual value bearing shipping labels are disclosed. The substantially perpetual viability of the value borne by perpetual value bearing shipping labels herein provides a shelf life which exceeds a shipping rate change epoch. Perpetual value bearing shipping labels of embodiments, although providing valid viable postage for use in obtaining shipping services, are provided as fungible products and do not include delivery or date information as pre-produced and made available to shippers in advance of their shipping activity. An on-line fulfillment system may be provided in which shippers may select a desired number of perpetual value bearing shipping labels in one or more value bearing amount for purchase by and delivery to the shipper for later use. Perpetual value bearing shipping labels may also be made available to shippers is through point of sale acquisition.

Abstract: A method of encoding and decoding video data is described. According to an aspect of an invention, luma and chroma components may have separate quadtree plus binary tree (QTBT) structures and a scaling parameter for a chroma coding block is determined based on one or more properties of a luma component.

Abstract: A method of decoding video data by a device is provided. Level values corresponding to a chroma coding block are received. The chroma coding block is one of chroma coding blocks resulting from partitioning a chroma coding tree block. A luma coding tree block corresponding to the chroma coding tree block is partitioned into luma coding blocks which are organized into quantization groups such that luma quantization parameters are determined for the luma coding tree block. One of the luma quantization parameters that is mapped to the chroma coding block is identified. A predictive quantization parameter is derived by using a value derived from the identified luma quantization parameter. A chroma quantization parameter is determined by adding a delta quantization parameter associated with each of the chroma coding blocks to the predictive quantization parameter. Transform coefficient values are generated based on the determined chroma quantization parameter.

Abstract: A method of performing motion vector prediction for coding video data is disclosed. A full precision motion vector mv is determined for generating a prediction for video block in a first picture. A rounded motion vector rmv having a less precision than the full precision motion vector mv is stored. A motion vector predictor candidate is generated for a video block in a second picture from the stored motion vector.

Abstract: Systems and methods are disclosed for selectively passing or blocking laser electromagnetic energy. A laser system comprises a shutter, whereby when the shutter is rotated one or more open areas of the shutter and one or more solid areas of the shutter are alternately positioned in a path of electromagnetic radiation emitted by the laser. The shutter may operate in different modes, including allowing all laser pulses to pass through in whole or in part, blocking all laser pulses from passing through, and alternately allowing and blocking laser pulses. In some embodiments, the shutter is controlled to allow only a part of each selected laser pulse to pass through. A laser system comprises a waveplate rotatable into different positions corresponding to different operating modes. The different operating modes may include allowing part and blocking part of the laser electromagnetic radiation.