Abstract: Implementations of firearm regulation systems may include a firearm safety system (FSS) configured to physically couple to a firearm. The FSS may include a locking mechanism configured to prevent the firearm from firing and a sensor configured to detect an environmental parameter. The firearm regulation system may also include a management system communicatively coupled to the FSS and a site safety system (SSS) communicatively coupled to the management system. The SSS may include one or more lockdown mechanisms.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCR) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: Implementations of firearm regulation systems may include a firearm safety system (FSS) configured to physically couple to a firearm. The FSS may include a locking mechanism configured to prevent the firearm from firing and a sensor configured to detect an environmental parameter. The firearm regulation system may also include a management system communicatively coupled to the FSS and a site safety system (SSS) communicatively coupled to the management system. The SSS may include one or more lockdown mechanisms.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: Implementations of firearm regulation systems may include a firearm safety system (FSS) configured to physically couple to a firearm. The FSS may include a locking mechanism configured to prevent the firearm from firing and a sensor configured to detect an environmental parameter. The firearm regulation system may also include a management system communicatively coupled to the FSS and a site safety system (SSS) communicatively coupled to the management system. The SSS may include one or more lockdown mechanisms.

Abstract: A brace assembly is configured for use with a longitudinal support of a firearm, such as a cylindrical bar or receiver extension. The assembly includes a brace body with a first or lower body member and a second or upper body member. The body members are configured to engage opposite surfaces of the longitudinal support. A brace portion can be attached to the brace body. In one example, a mounting post extends rearwardly from the brace body and the brace portion includes left and right brace members each having an upper end portion configured to attach to and pivot about the mounting post.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCR) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: Surface-modified glass and polymer membrane interfaces form high-electrical resistance seals that can be used in microfluidic valves and array devices tailored for electrophysiological measurements. The incorporation of high seal resistance valves into the array device allows only the desired electrophysiological signal to be detected by a patch clamp amplifier, enabling parallel experiments with one patch clamp amplifier, which can greatly improve the cost efficiency. To achieve the desired high seal resistance, surface modification was performed on the glass components to increase the interaction between the glass and the membrane surfaces. The valves exhibit seal resistance of >500 G? after modification, which is 100× higher than reported for unmodified valves.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: A brace assembly is configured for use with a longitudinal support of a firearm, such as a cylindrical bar or receiver extension. The assembly includes a brace body with a first or lower body member and a second or upper body member. The body members are configured to engage opposite surfaces of the longitudinal support. A brace portion can be attached to the brace body. In one example, a mounting post extends rearwardly from the brace body and the brace portion includes left and right brace members each having an upper end portion configured to attach to and pivot about the mounting post.

Abstract: Implementations of firearm regulation systems may include a firearm safety system (FSS) configured to physically couple to a firearm. The FSS may include a locking mechanism configured to prevent the firearm from firing and a sensor configured to detect an environmental parameter. The firearm regulation system may also include a management system communicatively coupled to the FSS and a site safety system (SSS) communicatively coupled to the management system. The SSS may include one or more lockdown mechanisms.

Abstract: Surface-modified silica microparticles that are functionalized with stabilized phospholipid vesicles are described herein. These stabilized vesicles can be functionalized with either transmembrane receptors or membrane associated receptors and used for affinity pull-down assays or other chromatographic separation modalities to provide affinity capture/concentration of low abundance ligands in complex mixtures with minimal sample preparation. Further described are methods and apparatus for forming polymer frits in a fused silica capillary. The capillary containing a monomer solution is placed between one or more heat sources connected to each other via a jig and operatively coupled to a temperature controller. The polymer frits are synthesized via thermal polymerization of the monomer solution using the heat sources, which allows for placement of the polymer frits at a spatially-defined location in the capillary.

Abstract: Implementations of firearm regulation systems may include a firearm safety system (FSS) configured to physically couple to a firearm. The FSS may include a locking mechanism configured to prevent the firearm from firing and a sensor configured to detect an environmental parameter. The firearm regulation system may also include a management system communicatively coupled to the FSS and a site safety system (SSS) communicatively coupled to the management system. The SSS may include one or more lockdown mechanisms.

Abstract: Methods, systems, and techniques for analyzing and managing time series workload data are provided. Example embodiments provide a Data Management and Analysis platform that enables end users to modernize their system configurations to incorporate external services techniques, such as cloud technologies, and to utilize virtualization technologies to host some of their functions in a manner that improves the overall performance of their configurations. This may be particularly useful in an IT environment with many interdependent systems where it is hard to analyze and determine where externally hosted or hybrid (e.g., both remote and local) systems might improve the overall delivery of services and cost to end users.

Abstract: Implementations of firearm regulation systems may include a firearm safety system (FSS) configured to physically couple to a firearm. The FSS may include a locking mechanism configured to prevent the firearm from firing and a sensor configured to detect an environmental parameter. The firearm regulation system may also include a management system communicatively coupled to the FSS and a site safety system (SSS) communicatively coupled to the management system. The SSS may include one or more lockdown mechanisms.

Abstract: A tunable optical device comprising an optical ring cavity and one or more pairs of electrodes for capacitive actuation of the optical tuning. Applying a potential difference to the electrodes applies a capacitive force to the optical ring cavity which changes the optical resonance frequency. The device can be used as a binary optical switch.