Abstract: The present invention relates to pharmaceutical products comprising fluticasone furoate for use in the treatment of COPD patients, particularly a subgroup of COPD patients that through analysis have been identified as possessing an eosinophil blood count of?150 cells/W. The present invention is further directed to methods for treating a patient with COPD which methods include identifying a patient that will respond to treatment and administering a pharmaceutical product of the present invention comprising fluticasone furoate to said patient.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: A method of processing a metal component is provided. The method includes laser cladding at least one surface of a metal component to obtain a laser cladded metal component having a predefined hardness. The method further includes heat-treating the laser cladded metal component to reduce the predefined hardness of the laser cladded metal component for performing metal working operations thereon. The method also includes cryogenically hardening the laser cladded metal component after the heat-treatment thereof, to induce the predefined hardness to the laser cladded metal component.

Abstract: A method for manufacturing an article from a metal alloy is described. The method includes supplying the metal alloy into a nozzle of a printing chamber, where temperature of the metal alloy is between a solidus and a liquidus temperature. Further, the method includes depositing the metal alloy in successive layers on a substrate plate, inside the printing machine, using the nozzle. The method also includes controlling movement of at least one of the nozzle and the substrate plate within the printing chamber based on an electronic data source of the article, where the electronic data source includes geometry of the article.

Abstract: A system of coating a component or part of a vehicle, device, or an apparatus with an abrasive resistant material (ARM) in order to increase the component or part's life cycle. A welding system can be used to deposit ARM between a lead electrode and a trail electrode and also deposit ARM behind the trail electrode. The welding system can also be used to deposit ARM that includes a lead electrode depositing the steel material and a trailing electrode that delivers an alloying material.

Abstract: A seal ring for a seal assembly includes a body and a seal flange. The body is generally cylindrical and extends along a longitudinal axis between a load end and a seal end. The seal flange is disposed at the seal end of the cylindrical body. The seal flange circumscribes the body and projects radially from the body to a distal perimeter of the seal flange. The seal flange includes a sealing face which is annular and disposed adjacent the distal perimeter. The seal ring is made from an alloy that includes between 8 percent and 13 percent by weight of iron, between 2 percent and 3 percent by weight of silicon, between 13 percent and 14 percent by weight of chromium, and at least 65 percent by weight of nickel.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: Architecture that employs encryption and storage of encryption keys to protect trusted client message content from an untrusted third-party hosted service. Each trusted user machine is configured to optionally apply security to messages. Rules determine when automatic protection is applied and the level of protection to apply. The trusted client automatically downloads the rules (or rules policies) from a trusted rules service and caches the rules locally. During composition, the rules analyze the message and automatically apply security template(s) to the message. The security template(s) encrypt the body of the message, but not the headers or subject. The untrusted message service processes the header and delivers the message to the correct recipient. The hosted service cannot view the contents of the message body, and only intended recipients of the protected message can view the message body. Offline protection is supported, and the user can override protection by the rules.

Abstract: A hosting provider operates a server system that provides a service to one or more tenants. The server system receives configuration data from the tenants. As part of providing the service to a given tenant, the server system attempts to access an external service due to the configuration data received from the given tenant identifying the external service. Service access errors can occur when attempting to access the external service. In response to determining that an error has occurred when attempting to access the external service, the server system sends a service access alert to a recipient associated with the given tenant. The service access alert notifies the recipient that the error has occurred.

Abstract: In some embodiments, macromolecules and related methods are provided. In some embodiments, an iterative growth process may be used to form a macromolecule comprising one or more repeat units comprising a functionalizable pendant group, with precise control over mass, length, backbone sequence, pendant group sequence, and/or stereochemistry, amongst other features. Macromolecules (e.g., non-natural macromolecules) form from the iterative growth process, described herein, may be used for a wide variety of applications, including the delivery of active agents.

Abstract: Architecture that employs encryption and storage of encryption keys to protect trusted client message content from an untrusted third-party hosted service. Each trusted user machine is configured to optionally apply security to messages. Rules determine when automatic protection is applied and the level of protection to apply. The trusted client automatically downloads the rules (or rules policies) from a trusted rules service and caches the rules locally. During composition, the rules analyze the message and automatically apply security template(s) to the message. The security template(s) encrypt the body of the message, but not the headers or subject. The untrusted message service processes the header and delivers the message to the correct recipient. The hosted service cannot view the contents of the message body, and only intended recipients of the protected message can view the message body. Offline protection is supported, and the user can override protection by the rules.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: A seal ring for a seal assembly includes a body and a seal flange. The body is generally cylindrical and extends along a longitudinal axis between a load end and a seal end. The seal flange is disposed at the seal end of the cylindrical body. The seal flange circumscribes the body and projects radially from the body to a distal perimeter of the seal flange. The seal flange includes a sealing face which is annular and disposed adjacent the distal perimeter. The seal ring is made from an alloy that includes between 8 percent and 13 percent by weight of iron, between 2 percent and 3 percent by weight of silicon, between 13 percent and 14 percent by weight of chromium, and at least 65 percent by weight of nickel.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: Architecture that employs encryption and storage of encryption keys to protect trusted client message content from an untrusted third-party hosted service. Each trusted user machine is configured to optionally apply security to messages. Rules determine when automatic protection is applied and the level of protection to apply. The trusted client automatically downloads the rules (or rules policies) from a trusted rules service and caches the rules locally. During composition, the rules analyze the message and automatically apply security template(s) to the message. The security template(s) encrypt the body of the message, but not the headers or subject. The untrusted message service processes the header and delivers the message to the correct recipient. The hosted service cannot view the contents of the message body, and only intended recipients of the protected message can view the message body. Offline protection is supported, and the user can override protection by the rules.

Abstract: Architecture that employs encryption and storage of encryption keys to protect trusted client message content from an untrusted third-party hosted service. Each trusted user machine is configured to optionally apply security to messages. Rules determine when automatic protection is applied and the level of protection to apply. The trusted client automatically downloads the rules (or rules policies) from a trusted rules service and caches the rules locally. During composition, the rules analyze the message and automatically apply security template(s) to the message. The security template(s) encrypt the body of the message, but not the headers or subject. The untrusted message service processes the header and delivers the message to the correct recipient. The hosted service cannot view the contents of the message body, and only intended recipients of the protected message can view the message body. Offline protection is supported, and the user can override protection by the rules.

Abstract: A hosting provider operates a server system that provides a service to one or more tenants. The server system receives configuration data from the tenants. As part of providing the service to a given tenant, the server system attempts to access an external service due to the configuration data received from the given tenant identifying the external service. Service access errors can occur when attempting to access the external service. In response to determining that an error has occurred when attempting to access the external service, the server system sends a service access alert to a recipient associated with the given tenant. The service access alert notifies the recipient that the error has occurred.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: Devices and related methods for nuclear magnetic resonance (NMR) analysis of particulate materials are provided including a detector chamber configured for insertion into an NMR spectrometer and configured to receive particulate materials in a fluid. A circulation chamber is attached to and in fluid communication with a first end of the detector chamber. A transition region is between the detector chamber and the circulation chamber, and a fluid supply interface is at a second end of the detector chamber that is configured to attach to a fluid source. The detector chamber, the circulation chamber and the transition region are sized and configured such that, when fluid flows from the fluid supply interface into the second end of the detector region, a circulating current is formed in the transition region and/or the circulation chamber such that the particulate matter is contained in the circulation chamber by the circulating current.

Abstract: A hosting provider operates a server system that provides a service to one or more tenants. The server system receives configuration data from the tenants. As part of providing the service to a given tenant, the server system attempts to access an external service due to the configuration data received from the given tenant identifying the external service. Service access errors can occur when attempting to access the external service. In response to determining that an error has occurred when attempting to access the external service, the server system sends a service access alert to a recipient associated with the given tenant. The service access alert notifies the recipient that the error has occurred.