Abstract: A surface covering composition of abrasion resistant character adapted for disposition in overlying bonded relation to a metal substrate. The surface covering composition includes metal carbide particles within a metal matrix at a packing factor of not less than about 0.6. Not less than about 40 percent by weight of the metal carbide particles are characterized by an effective diameter in the range of +14-32 mesh prior to introduction to the metal matrix. Not less than about 3 percent by weight of the metal carbide particles are characterized by an effective diameter of +60 mesh prior to introduction to the metal matrix.

Abstract: A track shoe for a track-type vehicle. The track shoe includes a base plate and a grouser projecting away from the base plate. A capping surface structure of substantially horseshoe shaped cross-section is disposed across a distal portion of the grouser. The capping surface structure covers portions of a distal edge surface and adjacent lateral surfaces. The capping surface structure is formed from an material characterized by enhanced wear resistance relative to portions of the grouser underlying the capping surface structure.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: Business to business secure mail may be provided. Consistent with embodiments of the invention, a protected message may be received. The recipient may request a token from a trust broker, submit the token to an authorization server associated with the sender, receive a user license from the authorization server; and decrypt the protected message using the user license. The protected message may restrict actions that may be taken by the recipient, such as forwarding to other users.

Abstract: A track shoe for a track-type vehicle. The track shoe includes a base plate and a grouser projecting away from the base plate. A capping surface structure of substantially horseshoe shaped cross-section is disposed across a distal portion of the grouser. The capping surface structure covers portions of a distal edge surface and adjacent lateral surfaces. The capping surface structure is formed from an material characterized by enhanced wear resistance relative to portions of the grouser underlying the capping surface structure.

Abstract: Methods and apparatus for providing clinical decision support to a healthcare provider. Eligibility criteria and quality measure information for a plurality of performance-based programs is stored and shared quality measures across performance-based programs are identified. Provider and patient characteristics are compared to the stored eligibility criteria and quality measure information to determine which quality measures apply to which providers and patients of the providers. A healthcare provider is provided with a notification at the point of care indicating a recommended action that, when performed by the healthcare provider will satisfy a quality measure in compliance with one or more performance-based programs. Customized reports may be generated and transmitted to program sponsors of performance-based programs, based on formatting rules specified by the program sponsors.

Abstract: A hosting provider operates a server system that provides a service to one or more tenants. The server system receives configuration data from the tenants. As part of providing the service to a given tenant, the server system attempts to access an external service due to the configuration data received from the given tenant identifying the external service. Service access errors can occur when attempting to access the external service. In response to determining that an error has occurred when attempting to access the external service, the server system sends a service access alert to a recipient associated with the given tenant. The service access alert notifies the recipient that the error has occurred.

Abstract: Devices and related methods for nuclear magnetic resonance (NMR) analysis of particulate materials are provided including a detector chamber configured for insertion into an NMR spectrometer and configured to receive particulate materials in a fluid. A circulation chamber is attached to and in fluid communication with a first end of the detector chamber. A transition region is between the detector chamber and the circulation chamber, and a fluid supply interface is at a second end of the detector chamber that is configured to attach to a fluid source. The detector chamber, the circulation chamber and the transition region are sized and configured such that, when fluid flows from the fluid supply interface into the second end of the detector region, a circulating current is formed in the transition region and/or the circulation chamber such that the particulate matter is contained in the circulation chamber by the circulating current.

Abstract: A therapeutic agent delivery device that is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: Novel compounds of the formula (I), in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.

Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.

Abstract: A web-based client for creating and accessing protected content may be provided. Consistent with embodiments of the invention, a webmail client may be provided allowing a user to apply a restriction template to a document. The webmail client may be further operative to decrypt and display the document and enforce the restriction against a recipient.

Abstract: Business to business secure mail may be provided. Consistent with embodiments of the invention, a protected message may be received. The recipient may request a token from a trust broker, submit the token to an authorization server associated with the sender, receive a user license from the authorization server; and decrypt the protected message using the user license. The protected message may restrict actions that may be taken by the recipient, such as forwarding to other users.

Abstract: A surface covering composition of abrasion resistant character adapted for disposition in overlying bonded relation to a metal substrate. The surface covering composition includes metal carbide particles within a metal matrix at a packing factor of not less than about 0.6. Not less than about 40 percent by weight of the metal carbide particles are characterized by an effective diameter in the range of +14-32 mesh prior to introduction to the metal matrix. Not less than about 3 percent by weight of the metal carbide particles are characterized by an effective diameter of +60 mesh prior to introduction to the metal matrix.

Abstract: Architecture that employs encryption and storage of encryption keys to protect trusted client message content from an untrusted third-party hosted service. Each trusted user machine is configured to optionally apply security to messages. Rules determine when automatic protection is applied and the level of protection to apply. The trusted client automatically downloads the rules (or rules policies) from a trusted rules service and caches the rules locally. During composition, the rules analyze the message and automatically apply security template(s) to the message. The security template(s) encrypt the body of the message, but not the headers or subject. The untrusted message service processes the header and delivers the message to the correct recipient. The hosted service cannot view the contents of the message body, and only intended recipients of the protected message can view the message body. Offline protection is supported, and the user can override protection by the rules.

Abstract: Novel compounds of the formula I in which D, X, X?, W, Y, T and R1 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.

Abstract: Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses, wherein R1, R2, R3 and R4 are as defined in the claims.

Abstract: The present invention relates to the polypeptide Saratin and its use for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, where the Saratin polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices or vascular grafts.