Abstract: A personal wearable communication and speaker entertainment system which provides improved quality audio response and which does not interfere with the wearer's activities or block environmental sounds is disclosed. The speaker system is connected to or in communication with a conventional source of audio signals, such as radio, tape player, CD player, cellular telephone or the like.

Abstract: The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

Abstract: The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

Abstract: A lens design comprising a positive lens made of barium fluoride crystal material and a negative lens element made of glass with dispersive properties common to the family of Schott type materials enabling an object to be imaged with superior chromatic aberration correction in the spectral range extending from the visible to the near-infrared region of the electromagnetic spectrum. The achromatic lens design as described has negligible residual and higher order chromatic aberration throughout the visible, the near-infrared or simultaneously both the visible and near-infrared regions of the electromagnetic spectrum.

Abstract: The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced capacity of O-glycosylation when expressed in yeast compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.

Abstract: A personal wearable communication and speaker entertainment system which provides improved quality audio response and which does not interfere with the wearer's activities or block environmental sounds is disclosed. The speaker system is connected to or in communication with a conventional source of audio signals, such as radio, tape player, CD player, cellular telephone or the like.

Abstract: A personal wearable communication and speaker entertainment system which provides improved quality audio response and which does not interfere with the wearer's activities or block environmental sounds is disclosed. The speaker system is connected to or in communication with a conventional source of audio signals, such as radio, tape player, CD player, cellular telephone or the like.

Abstract: The invention provides novel caspase recruitment domain 11 (CARD11), also known as CARMA-1, polypeptides, nucleic acids encoding them and methods for making and using them. In one aspect, the polypeptides of the invention have NFkB activating activity. The invention also provides non-human transgenic animals, e.g., mice, comprising the CARD11 nucleic acids of the invention. The invention also provides pharmaceutical compositions comprising a nucleic acid or polypeptide of the invention. Administration of a pharmaceutical composition of the invention to a subject is used to generate a toleragenic immunological environment in the subject. This can be used to tolerize the subject to an antigen. The invention also provides inbred mouse strains homozygous for a non-wild type CARD11 allele. This genotype results in mice having a phenotype comprising dermatitis, B cell defects and T cell defects.

Abstract: An animal bed having an cushioning core material surrounded by an encasing. The encasing has a face textile disposed in contacting relation across and odor adsorbing layer. The odor adsorbing layer includes a odor adsorbing agent adhered to an interior of the face textile. A related method is also provided.

Abstract: An animal bed having an cushioning core material surrounded by an encasing. The encasing has a face textile, odor adsorbing layer, and a backing material. The odor adsorbing layer includes a odor adsorbing agent adhered to an interior of the face textile. The backing layer covers the odor adsorbing layer.

Abstract: A method and apparatus is disclosed for a multimedia data communications system. The data communication system is provided for use in a work environment to establish a connection between a data communication device and an access point in connection with a communication system and with a multimedia system providing a multimedia signal. The data communication system includes a data port associated with the access point, a multimedia conversion circuit associated with the access point and in communication with the data port for converting the multimedia signal from the multimedia system into a multimedia data signal for transmission to the data communication device and for converting a multimedia data signal from the data communication device for transmission to the multimedia device, and a device port associated with the data communication device so that a data link can be established between the data port and the device port.

Abstract: A wireless data communication system for establishing a data link between a portable communication device and an interface circuit, such as an interface circuit to a LAN, includes a plurality of transceivers in communication with a control circuit. Each of the transceivers is configured to transmit and receive wireless signals within a defined transceiver space. The plurality of transceiver spaces combine to define a communication space. The control circuit detects the presence of a wireless signal within the communications space by sequentially scanning the transceivers to determine which transceiver is receiving the signal. Once the signal is detected, the control circuit automatically locks onto the transceiver receiving the signal, thereby enabling establishment of a wireless data link between the communication device and the interface circuit. The control circuit continues to monitor the established data link to determine whether data communications are disrupted.

Abstract: The present invention relates to recombinant hemoglobin solutions containing reduced amounts of protoporphyrin IX and to methods of producing such hemoglobin solutions. The methods are accomplished by overexpressing the hemH gene in a suitable host cell or by increasing the production of hemH in a host cell, for example, by integration of the hemH gene into the chromosome of the host cell or by inserting multiple copies of the gene in host cells naturally having a hemH gene.

Abstract: The present invention provides the cDNA sequence encoding bovine dipeptidylaminopeptidase 1. The invention demonstrates that bovine DAP 1 coded by a single cDNA. The mature protein is derived from a single polypeptide consisting of a signal peptide, and a major polypeptide which is processed to generate the a subunit, b subunit and g subunit.

Abstract: The present invention provides the cDNA sequence encoding bovine dipeptidylaminopeptidase 1. The invention demonstrates that bovine DAP 1 coded by a single cDNA. The mature protein is derived from a single polypeptide consisting of a signal peptide, and a major polypeptide which is processed to generate the a subunit, b subunit and g subunit.