Patents by Inventor Christopher Cheng

Christopher Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12264175
    Abstract: Provided herein are compositions and methods for preparation of 5? end region-modified mRNAs. In particular, the instant disclosure relates to novel mRNA 5? end region motifs and sequence initiators therefore together with assays that are capable of measuring the aspects of the functionality of those motifs and sequence initiators. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Grant
    Filed: March 1, 2023
    Date of Patent: April 1, 2025
    Assignee: Verve Therapeutics, Inc.
    Inventors: Christopher Cheng, Kallanthottathil Rajeev, Caroline Reiss
  • Publication number: 20250084409
    Abstract: Provided herein are compositions and methods for preparation of 5? end region-modified mRNAs. In particular, the instant disclosure relates to novel mRNA 5? end region motifs and sequence initiators therefore together with assays that are capable of measuring the aspects of the functionality of those motifs and sequence initiators. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Application
    Filed: November 25, 2024
    Publication date: March 13, 2025
    Inventors: Christopher Cheng, Kallanthottathil Rajeev, Caroline Reiss, Kui Wang, Jay Leipheimer
  • Patent number: 12203110
    Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: January 21, 2025
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventors: Andre Cohnen, Moritz Schmidt, Wayne Coco, Michael Biag Gamalinda, Ashish Gupta, Christian Pitzler, Florian Richter, Jan Tebbe, Christopher Cheng, Ryo Takeuchi, Caroline W. Reiss
  • Publication number: 20240390520
    Abstract: Disclosed herein are novel gene editing systems capable of being delivered to a subject intravenously through a lipid nano particle pharmaceutical formulation and producing durable in vivo editing of a target gene, such as ANGPTL3, with high on-target gene editing efficiency, reduced or low off-target effect, and no germline editing. The gene editing systems comprise a chemically modified guide nucleic acid sequence with a spacer having a specified arrangement of deoxyribonucleotides and ribonucleotides. The novel gene editing systems comprise mRNA that encodes the gene editor proteins, which may include a modified nickase component. Methods of disease treatments using the gene editing systems are also disclosed.
    Type: Application
    Filed: March 21, 2024
    Publication date: November 28, 2024
    Inventors: Andrew M. Bellinger, Kallanthottathil G. Rajeev, Caroline Reiss, Jamie Denizio, Hariharan Jayaram, Sowmya Iyer, Sara Cristina De Almeida Pinto Garcia, Kui Wang, Alexandra Chadwick, Christopher Cheng, Richard Glenn Lee, Ellen Rohde
  • Publication number: 20240390523
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Application
    Filed: February 20, 2024
    Publication date: November 28, 2024
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • Patent number: 12115230
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: October 15, 2024
    Assignee: VERVE THERAPEUTICS, INC.
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • Publication number: 20240316212
    Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9.
    Type: Application
    Filed: January 23, 2024
    Publication date: September 26, 2024
    Inventors: Kallanthottathil G. Rajeev, Lisa N. Kasiewicz, Padma Malyala, Souvik Biswas, Ellen Rohde, Alexandra Chadwick, Caroline Reiss, Christopher Cheng, Andrew Bellinger
  • Patent number: 12029795
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: July 9, 2024
    Assignee: VERVE THERAPEUTICS, INC.
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • Publication number: 20230340435
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Application
    Filed: April 9, 2021
    Publication date: October 26, 2023
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • Publication number: 20230331763
    Abstract: Provided herein are compositions and methods for preparation of 5? end region-modified mRNAs. In particular, the instant disclosure relates to novel mRNA 5? end region motifs and sequence initiators therefore together with assays that are capable of measuring the aspects of the functionality of those motifs and sequence initiators. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Application
    Filed: March 1, 2023
    Publication date: October 19, 2023
    Inventors: Christopher Cheng, Kallanthottathil Rajeev, Caroline Reiss, Kui Wang, Athul Sanjeev
  • Publication number: 20230193239
    Abstract: Described herein are methods of purifying polynucleotides, e.g., imRNA and oligonucleotides, e.g., probes, primers and siRNA, using monolithic columns with immobilized ligands coupled to the monolithic column. Also described are monolithic columns for purifying polynucleotides from a sample; and methods of preparing such columns.
    Type: Application
    Filed: November 21, 2022
    Publication date: June 22, 2023
    Inventors: Jared DAVIS, Joanna DEBEAR, Christopher CHENG
  • Publication number: 20230158174
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 25, 2023
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • Publication number: 20230159926
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 25, 2023
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • Publication number: 20220364078
    Abstract: Described herein is method for purifying messenger RNA (mRNA) encoding a DNA endonuclease from a sample, the method comprising: (a) loading the sample comprising the mRNA onto a monolithic matrix comprising a poly(dT) or poly(U) nucleic acid molecule linked/coupled to the monolithic matrix under conditions allowing the mRNA to hybridize with the poly(dT) or poly(U) nucleic acid molecule; (b) eluting the mRNA from the monolith matrix after one or more contaminants have been separated from the bound mRNA; and (c) separating the mRNA from dsRNA by adsorption chromatography, thereby resulting in a purified mRNA solution.
    Type: Application
    Filed: May 11, 2022
    Publication date: November 17, 2022
    Inventors: Christopher Cheng, Karolina Kosakowska, Caroline W. Reiss, Kui Wang
  • Patent number: 11490880
    Abstract: A biopsy and therapy device comprising: a needling unit for holding and inserting a biopsy needle; an imaging module comprising an ultrasound probe and an actuator for moving the probe in a reciprocal action; a first arcuate slide; a second arcuate slide in sliding engagement with the first arcuate slide and a linkage to which the first arcuate slide is mounted; said linkage arranged to move the first and second arcuate slides within a vertical plane; said needling unit mounted to said arcuate slide wherein the first and second arcuate slides are mounted perpendicular to each other so as to rotate the needling unit about respective first and second principal axes.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: November 8, 2022
    Inventors: Chew Loong Yap, Yibao Shi, Teoh Hwa Ang, Poon Kiong Gilbert Mak, Hongjun Chen, Wai Sam Christopher Cheng, Shyi Peng Yuen, Sun Sien Henry Ho
  • Publication number: 20220068540
    Abstract: An example device includes a mounting surface including a first material having a first coefficient of thermal expansion (CTE). The device includes an intermediate plate coupled to the mounting surface and comprising a second material having a second CTE. The device includes a ferrite core coupled to the intermediate plate and comprising a third material having a third CTE, wherein the second CTE of the intermediate plate is between the first CTE of the mounting surface and the third CTE of the ferrite core.
    Type: Application
    Filed: August 28, 2020
    Publication date: March 3, 2022
    Inventor: Christopher Cheng
  • Publication number: 20210054353
    Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.
    Type: Application
    Filed: March 19, 2019
    Publication date: February 25, 2021
    Inventors: Andre COHNEN, Moritz SCHMIDT, Wayne COCO, Michael Biag GAMALINDA, Ashish GUPTA, Christian PITZLER, Florian RICHTER, Jan TEBBE, Christopher CHENG, Ryo TAKEUCHI, Caroline W. REISS
  • Publication number: 20200077993
    Abstract: A biopsy and therapy device comprising: a needling unit for holding and inserting a biopsy needle; an imaging module comprising an ultrasound probe and an actuator for moving the probe in a reciprocal action; a first arcuate slide; a second arcuate slide in sliding engagement with the first arcuate slide and a linkage to which the first arcuate slide is mounted; said linkage arranged to move the first and second arcuate slides within a vertical plane; said needling unit mounted to said arcuate slide wherein the first and second arcuate slides are mounted perpendicular to each other so as to rotate the needling unit about respective first and second principal axes.
    Type: Application
    Filed: November 15, 2019
    Publication date: March 12, 2020
    Inventors: Chew Loong YAP, Yibao SHI, Teoh Hwa ANG, Poon Kiong Gilbert MAK, Hongjun CHEN, Wai Sam Christopher CHENG, Shyi Peng John YUEN, Sun Sien Henry HO
  • Publication number: 20190203199
    Abstract: Described herein are methods of purifying polynucleotides, e.g., imRNA and oligonucleotides, e.g., probes, primers and siRNA, using monolithic columns with immobilized ligands coupled to the monolithic column. Also described are monolithic columns for purifying polynucleotides from a sample; and methods of preparing such columns.
    Type: Application
    Filed: May 24, 2017
    Publication date: July 4, 2019
    Inventors: Jared DAVIS, Joanna DEBEAR, Christopher CHENG
  • Publication number: 20160078689
    Abstract: A system for coordinating valet services comprises a server including a server controller, a server database in communication with the controller, and server memory in communication with the controller, the server memory storing server program instructions that are executable by the controller. The system also includes a customer mobile device and a valet mobile device associated with a customer application and a valet application, respectively. The customer application is associated with a vehicle identifier, and the valet application is associated with a valet identifier. In response to receipt of the valet identifier and the vehicle identifier by the server from the customer application, the server controller prompts the valet application to request a ticket number.
    Type: Application
    Filed: September 14, 2015
    Publication date: March 17, 2016
    Inventor: Preston Christopher Cheng