Abstract: Compounds of formula (I), wherein one of R1 and R2 is selected from a group (IA), ring A is substituted pyridin-z-yl of thiazol-z-yl, the other substituents are as described in the description and their use in the treatment or prevention of a disease or medical conditions mediated through glucokinase.

Abstract: Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11?HSD1 are described.

Abstract: This invention relates to a phase shifting device, which generally comprises of rigid chassis, in the form of an aluminium plate, which can form a ground plane for feed lines (12) printed on a printed circuit board (16), which is mounted on the chassis, a rigid RF transparent block, which is fixed to an actuator arm and mounting bolts for slidably mounting block and actuator on the chassis. A flexi circuit, or the equivalent, (18) is attached to the block and is printed with generally c-shaped conductive strips (23), which form connections at open parts of the feed lines, in such a manner that movement of the block will cause changes in the effective lengths of the feed lines (12) and hence the relative phases of antennas fed by those feed lines.

Abstract: The present invention is directed toward Group 4, 5, 6, 7, 8, 9, 10 or 11 transition metal compounds containing neutral, mono- or di-anionic tridentate nitrogen/oxygen based ligands that are useful, with or without activators, to polymerize olefins, particularly a-olefins, or other unsaturated monomers. For the purposes of this disclosure, “?-olefins” includes ethylene. The present invention is also directed toward Group 4, 5, 6, 7, 8, 9, 10 or 11 transition metal compounds containing neutral, bidentate nitrogen/oxygen based ligands that are useful to polymerize olefins, particularly ?-olefins, or other unsaturated monomers.

Abstract: A polymer blend for use in a biomedical application comprising: (A) a polymer A, bearing zwitterionic pendant groups; and (B) a hydrophobic addition polymer B, selected from the group consisting silyl(alk)acrylates, alkyl(alk)acrylamides, dialkyl(alk)acrylamides, and alkyl(alk)acrylate polymers, wherein the structure of the blend exhibits phase separation forming a micro-phase segregated structure at a surface. Articles, methods of production and liquid blend compositions are also disclosed. Preferably A is a copolymer of 15 to 30 mole % 2-methacryloyloxyethy1-2-trimethylammonium ethyl phosphate inner salt and 85 to 70 mole % of a C6-18 alkyl methacrylate, and B is a homopolymer of a C4-18 alkyl(meth)acrylate, blended in weight proportions of 1:1 to 1:50.

Abstract: Glazing panels such as vehicle glazing panels bonded to a supporting frame are released by firstly arranging light energy delivery means adjacent the panel and subsequently transmitting light energy from the delivery means through the panel thereby to effect release of the panel from the frame. The light may be pulsed according to a predetermined regime and may be delivered by a discharge lamp having rapidly attenuating intensity. The mechanism of panel release may be by thermal degradation of the bonding material, cleavage of material at a surface of, or within the body of the panel, or a combination of such mechanisms.

Abstract: A method of screening a test agent for its ability to cause a thermodynamic change in a cell-free sample, comprising the steps of: i) measuring the temperature of said sample using electrothermometry; ii) contacting the sample with said test agent; iii) measuring the temperature of the sample resulting from step (ii) using electrothermometry; and iv) comparing the temperature obtained in step (i) with the temperature obtained in step (iii), wherein temperature measurement steps (i) and (iii) are conducted using a non-invasive electro thermometric method.

Abstract: An electroluminescent lamp or display comprises a first electrode on a substrate interdigitated with a second electrode on the same substrate. A layer of electroluminescent material is provided over the electrodes. The arrangement has the advantage that light from the electroluminescent material does not need to pass through either of the electrodes. The substrate may be a printed circuit board. In an alternative embodiment the second electrode is provided over the layer of electroluminescent material and gaps are provided in the electrode for the emission for light. The electroluminescent lamps may be used to form a seven-segment display.

Abstract: Glazing panels such as vehicle windscreens bonded to a supporting frame are released by firstly arranging light energy delivery means adjacent the panel and subsequently transmitting light energy from the delivery means through the panel thereby to effect release of the panel from the frame. The light may be pulsed according to a predetermined regime and may be delivered by a discharge lamp having rapidly attenuating intensity, or quasi continuous wave pulsed laser. The mechanism of panel release may be by thermal degradation of the bonding material, cleavage of material at a surface of, or within the body of the panel, or a combination of such mechanisms.

Abstract: A participant response system comprises a plurality of handsets for allowing a participant of an event to input a response. Each handset comprises a wireless handset having a keyboard for allowing a user to input a response. The handsets are configurable either as a participant response handset to allow a participant to enter a response, or as a base station. The handset also includes audio capability to allow participants to receive and input audio.

Abstract: BTL.010 is a novel human serine proteinase inhibitor of the Kunitz family that exhibits greater potency towards neutral serine proteinases, particularly leukocyte elastase and proteinase 3 than towards trypsin-like proteinases. BTL.010, or variants thereof, may be employed as therapeutics in diseases such as emphysema, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, cystic fibrosis, rheumatoid arthritis, organ failure, and glomerulonephritis in which uncontrolled proteolysis due to neutral serine proteinase activity results in tissue damage.

Abstract: An apparatus for repairing a crack in a vehicle windshield includes a high frequency vibration applicator and repair material. The high frequency vibration applicator includes a high frequency vibration generator, an elongate vibration delivery probe, and a handle grip for manipulation of the high frequency vibration applicator by a user. The vibration delivery probe delivers high frequency vibration from the generator to the windshield via a tip of the probe. A method of repairing a crack in a vehicle windshield includes infilling the crack with a repair material, applying to the windshield a tip of an elongate vibration delivery probe of a high frequency vibration applicator, and manipulating the high frequency vibration applicator to track the probe in a longitudinal direction of the crack.

Abstract: Glazing panels such as vehicle windscreens bonded to a supporting frame are released by firstly arranging light energy delivery means adjacent the panel and subsequently transmitting light energy from the delivery means through the panel thereby to effect release of the panel from the frame. The light may be pulsed according to a predetermined regime and may be delivered by a discharge lamp having rapidly attenuating intensity, or quasi continuous wave pulsed laser. The mechanism of panel release may be by thermal degradation of the bonding material, cleavage of material at a surface of, or within the body of the panel, or a combination of such mechanisms.

Abstract: Bonded screens such as vehicle windscreens (1) bonded to a supporting frame (5) by homogeneous bonding material (6) are released by firstly arranging energy delivery means (9) adjacent the screen and subsequently transmitting energy from the delivery means through the screen thereby to effect release of the screen (1) from the frame (5) by either causing degradation of some of the homogeneous bonding material and/or cleavage or degradation of the screen material. The energy delivered may, for example, be ultrasonic or laser radiation, and is preferably arranged to be concentrated at a predetermined localized region to enhance the release mechanism.

Abstract: A hand-held operator manipulatable applicator device is used for dispensing adhesive bonding material to bond a panel (such as an automotive glazing panel). The device has a body containing a delivery channel for delivering adhesive to an outlet nozzle and a heating system disposed within the body for heating the bonding material in the channel to produce a substantially uniform outlet dispensing temperatures via the nozzles.

Abstract: A glazing panel is fitted in a frame by placing the glazing panel in register with the frame with soft state bonding material interposed. An energy field is then set up to act upon the bonding material the energy field acting to promote curing of the bonding material. Preferably a microwave energy field is set up and the energy is applied for a predetermined period, typically less than 60 seconds.

Abstract: BTL.009 is a novel human serine proteinase inhibitor of the Kunitz family that exhibits greater potency towards neutral serine proteinases, particularly leukocyte elastase, and chymotrypsin than towards trypsin-like proteinases. BTL.009, or variants thereof, may be employed as therapeutics in diseases such as emphysema, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, cystic fibrosis, rheumatoid arthritis, organ failure, and glomerulonephritis in which uncontrolled proteolysis due to neutral serine proteinase activity results in tissue damage.

Abstract: BTL.010 is a novel human serine proteinase inhibitor of the Kunitz family that exhibits greater potency towards neutral serine proteinases, particularly leukocyte elastase-, and proteinase 3, than towards trypsin-like proteinases. BTL.010, or variants thereof, may be employed as therapeutics in diseases such as emphysema, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, cystic fibrosis, rheumatoid arthritis, organ failure, and glomerulonephritis in which uncontrolled proteolysis due to neutral serine proteinase activity results in tissue damage.

Abstract: A fluid flow meter comprises a pair of transducers spaced apart in the direction of fluid flow. A transmitter causes acoustic signals to be transmitted in both directions through the fluid by the transducers. A processor determines information relating to the fluid flow by monitoring the time of flight of acoustic signals received by the transducers. Part of the space between the transducers defines a flow path consisting of a flow structure having a plurality of parallel fluid flow passages which extend axially in the direction of flow, wherein the cross-sectional diameters of the passages are chosen such that substantially plane acoustic waves only are transmitted through the passages by the fluid, and wherein under working conditions that fluid flows through each passage such that the ratio of the volume flow rate through the passage to the total volume flow rate remains substantially constant with respect to the total volume flow rate.