Patents by Inventor Christopher Demerson
Christopher Demerson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4108998Abstract: Furo[3,4-b]quinoline derivatives, having both an alkyl substituent and an alkyl or alkylene amide substituent at position 3 are disclosed. The derivatives can be further substituted at positions 1 and 9. The furo[3,4-b]quinoline derivatives of this invention are useful antihypertensive and antimicrobial agents. Methods for the preparation and use of these derivatives are also disclosed.Type: GrantFiled: November 8, 1976Date of Patent: August 22, 1978Assignee: American Home Products Corp.Inventors: Christopher A. Demerson, Leslie G. Humber
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Patent number: 4100277Abstract: 4,1-Benzoxazonine derivatives characterized by having an alkyl radical at the 3-position as well as being further substituted at the 3-position are disclosed. The derivatives are optionally further substituted at positions 1,2,6 and 7. The 4,1-benzoxazine derivatives of this invention are useful for treating hypertension and microbial infections. Methods for the preparation and use of these derivatives are described.Type: GrantFiled: November 8, 1976Date of Patent: July 11, 1978Assignee: American Home Products CorporationInventors: Christopher A. Demerson, Leslie G. Humber
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Patent number: 4076831Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.Type: GrantFiled: December 13, 1976Date of Patent: February 28, 1978Assignee: American Home Products CorporationInventors: Christopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
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Patent number: 4070371Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.Type: GrantFiled: December 13, 1976Date of Patent: January 24, 1978Assignee: American Home Products CorporationInventors: Christopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
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Patent number: 4066763Abstract: Thiazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-thiazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The thiazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.Type: GrantFiled: December 13, 1976Date of Patent: January 3, 1978Assignee: Ayerst McKenna and Harrison Ltd.Inventors: Christopher A. Demerson, Leslie G. Humber, George Santroch, Thomas A. Dobson, Ivo Jirkovsky
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Patent number: 4066779Abstract: Pyranolindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.Type: GrantFiled: October 28, 1976Date of Patent: January 3, 1978Assignee: Ayerst, McKenna and Harrison Ltd.Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
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Patent number: 4066780Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.Type: GrantFiled: October 28, 1976Date of Patent: January 3, 1978Assignee: Ayerst McKenna and Harrison Ltd.Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
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Patent number: 4056538Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[ 3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino position of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 posses two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8.Type: GrantFiled: October 18, 1976Date of Patent: November 1, 1977Assignee: Ayerst, McKenna & Harrison LimitedInventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
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Patent number: 4056537Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8.Type: GrantFiled: October 18, 1976Date of Patent: November 1, 1977Assignee: Ayerst McKenna and Harrison Ltd.Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
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Patent number: 4041169Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.Type: GrantFiled: October 28, 1976Date of Patent: August 9, 1977Assignee: Ayerst McKenna and Harrison Ltd.Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
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Patent number: 4036842Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-l-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.Type: GrantFiled: September 15, 1975Date of Patent: July 19, 1977Assignee: American Home Products CorporationInventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
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Patent number: 4021451Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.Type: GrantFiled: June 5, 1975Date of Patent: May 3, 1977Assignee: American Home Products CorporationInventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
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Patent number: 4012417Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.Type: GrantFiled: March 5, 1975Date of Patent: March 15, 1977Assignee: American Home Products CorporationInventors: Christopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
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Patent number: 4012511Abstract: Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.Type: GrantFiled: July 7, 1975Date of Patent: March 15, 1977Assignee: Ayerst McKenna & Harrison Ltd.Inventors: Christopher A. Demerson, Leslie G. Humber, George Santroch, Thomas A. Dobson, Ivo Jirkovsky
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Patent number: 4003913Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.Type: GrantFiled: March 5, 1975Date of Patent: January 18, 1977Assignee: Ayerst McKenna and Harrison Ltd.Inventors: Christopher A. Demerson, Lesie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
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Patent number: 3995052Abstract: Indenopyran- and indenothiopyranalkylamine derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of an indeno[2,1-c]pyran or indeno[2,1-c]thiopyran nucleus are disclosed. Also included are the corresponding derivatives having an indeno[1,2-c]pyran and an indeno[1,2-c]-thiopyran nucleus. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incoporated into a heterocyclic amine radical. The derivatives are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The indenopyran- and indenothiopyranalkylamine derivatives of this invention are useful antidepressant agents. Methods for their preparation and use are disclosed.Type: GrantFiled: May 19, 1975Date of Patent: November 30, 1976Assignee: Ayerst McKenna and Harrison Ltd.Inventors: Ivo Jirkovsky, Leslie G. Humber, Christopher A. Demerson, Thomas A. Dobson
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Patent number: 3978066Abstract: 1,3-Dihydropyrrolo[4,3,2-de]isoquinoline derivatives characterized by an amino or hydrazino substituent at position 5 are disclosed. Also included are the related 4,6-dihydropyrrolo[4,3,2-de]-s-triazolo[3,4-a]isoquinoline and its 8-methyl derivative. The compounds are antidepressant and antihypertensive agents. Methods for their preparation and use are disclosed.Type: GrantFiled: May 19, 1975Date of Patent: August 31, 1976Assignee: Ayerst, McKenna and Harrison Ltd.Inventors: Adolf H. Philipp, Christopher A. Demerson, Leslie G. Humber
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Patent number: 3974179Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.Type: GrantFiled: October 10, 1974Date of Patent: August 10, 1976Assignee: American Home Products CorporationInventors: Christopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
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Patent number: 3962236Abstract: Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.Type: GrantFiled: May 28, 1974Date of Patent: June 8, 1976Assignee: Ayerst McKenna and Harrison Ltd.Inventors: Christopher A. Demerson, Leslie G. Humber, George Santroch, Thomas A. Dobson, Ivo Jirkovsky
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Patent number: 3950343Abstract: 1,3,4,5-Tetrahydropyrrolo[4,3,2-de]isoquinoline and its N-alkyl derivatives are disclosed. The compounds are antidepressant and antihypertensive agents. Methods for their preparation and use are disclosed.Type: GrantFiled: November 6, 1973Date of Patent: April 13, 1976Assignee: Ayerst, McKenna and Harrison Ltd.Inventors: Adolf H. Philipp, Christopher A. Demerson, Leslie G. Humber