Abstract: Integrated circuits (ICs) that avoid or mitigate creation of changes in accumulated charge in a silicon-on-insulator (SOI) substrate, particularly an SOI substrate having a trap rich layer. In one embodiment, a FET is configured such that, in a standby mode, the FET is turned OFF while maintaining essentially the same VDS as during an active mode. In another embodiment, a FET is configured such that, in a standby mode, current flow through the FET is interrupted while maintaining essentially the same VGS as during the active mode. In another embodiment, a FET is configured such that, in a standby mode, the FET is switched into a very low current state (a “trickle current” state) that keeps both VGS and VDS close to their respective active mode operational voltages. Optionally, S-contacts may be formed in an IC substrate to create protected areas that encompass FETs that are sensitive to accumulated charge effects.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: Provided is a process including: receiving one or more write requests to write a plurality of values to a plurality of fields in one or more tuples of a relational database, different ones of the values corresponding to different ones of the fields, detecting duplicates of the values with steps for expediting detection of duplicates, and selecting a first subset of the values based on the first subset of values corresponding to fields in a first subset of the fields, the first subset of fields being designated as higher-security fields than a second subset of fields among the plurality of fields.

Abstract: A method at an electronic device with a display includes: displaying a user interface having a first region and a second region; receiving, and displaying in the first region of the user interface, a live video stream of a physical environment captured by a remote video camera; displaying, in the second region, a timeline corresponding to a timespan for a first portion of a duration during which the live video stream may have been recorded; in response to receiving a user interaction to move the timespan to a second portion of the duration, transitioning the displayed timeline to a new timeline that corresponds to the timespan for the second portion, and while transitioning, displaying, in the first region, a subset of video frames representing the first and/or second portion of the duration.

Abstract: A method of determining a position of a diverter of a fluid circulation system in a dishwasher appliance includes determining a total amount of water supplied to the dishwasher appliance; activating a pump at a predetermined speed in response to determining the total amount of water supplied to the dishwasher appliance, the predetermined speed being based on the determined total amount of water; measuring a fluid pressure of an amount of sump water provided within a sump of the dishwasher appliance after activating the pump at the predetermined speed, the amount of sump water being at least part of the total amount of water; and determining a position of the diverter in response to measuring the fluid pressure of the amount of sump water, the position of the diverter being dependent on the measured fluid pressure.

Abstract: A method for automated manufacturing of shoe soles comprises the steps of: loading a transfer device with at least one outsole element and at least one supporting element, positioning the loaded transfer device adjacent a first part and a second part of a sole mold, transferring the at least one outsole element from the transfer device to the first part and transferring the at least one supporting element from the transfer device to the second part of the sole mold, filling the sole mold with a plurality of individual particles, and applying a medium to bond and/or fuse the particles with each other and with the at least one outsole element.

Abstract: Provided herein are an optical test platform and corresponding method of manufacturing the same. The test platform may include a shell defining a cavity for receiving a sample tube, a first aperture, and a second aperture. The first aperture and the second aperture of the shell may each be configured to optically couple the cavity with an exterior of the shell. The test platform may further include a first window and a second window embedded in the shell. The first window may seal a first aperture and the second window may seal a second aperture. The first window and second window may each permit the optical coupling of the cavity with the exterior of the shell. The first window and the second window may be optically coupled via the cavity, and the shell may prohibit optical coupling between the first window and the second window through the shell.

Abstract: A plurality of video items comprising a first subset of video items and a second subset of video items are received at a client device. A graphical user interface comprising a scrollable area to present the plurality of video items and a focus area to present one of the plurality of video items is presented. Video items of the second subset of video items are presented in or adjacent to the focus area when the first subset of video items is visible in the scrollable area and prior to the second subset of video items becoming visible in the scrollable area, and a size of the video items from the second subset of video items presented in or adjacent to the focus area is smaller than a size of video items of the first subset of video items presented in the scrollable area.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A system and method are provided for manufacturing a tower structure. Accordingly, one or more layers of a wall element are deposited with a printhead assembly. At least one recess is defined in the wall element. The recess(es) has a single, circumferential opening positioned along an inner reference curve or an outer reference curve of the wall element. The recess(es) also has a depth which extends in a radial direction and intersects a midline reference curve. A reinforcing element is placed entirely within the recess(es) at the midline reference curve.

Abstract: A spinal interbody device (IBD) includes a solid wall that at least partially defines a boundary of the IBD and a porous body connected to the solid wall. The porous body includes a plurality of sections that form at least a portion of both a superior and inferior bone interface side of the IBD. Each section of the porous body has a different porosity than an adjacent section such that the porosities increase toward a center of the IBD.

Abstract: A mask system for delivery of respiratory therapy to a patient includes a nares portion and a mouth portion and an inlet conduit connected to at least one of the nares portion and the mouth portion to deliver the pressurized, breathable gas. The mask system is adapted to selectively utilize the nares portion and/or the mouth portion in a first mode utilizing both the nares portion and the mouth portion, and in a second mode utilizing the nares portion and not utilizing the mouth portion.

Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: According to embodiments, a coated pharmaceutical container may include a pharmaceutical container comprising an interior surface and an exterior surface, wherein the pharmaceutical container may include a glass composition that has Class HGA1 hydrolytic resistance when tested according to the ISO 720 testing standard. The coated pharmaceutical container may further include a coating bonded to at least a portion of the exterior surface but not on any portion of the interior surface. The coating may have a coefficient of friction less than or equal to 0.7, and the coated pharmaceutical container may be thermally stable after heating at a temperature of at least 260° C. for a time period of 30 minutes.

Abstract: An absorbent article includes a first waist region, a second waist region, and a crotch region disposed between the first and second waist regions; and a chassis having a topsheet, a backsheet, and an absorbent core positioned between the topsheet and the backsheet. The article also includes a side panel having an ultrasonically bonded, gathered laminate. The laminate has an elastomeric layer and a substrate and is joined to the chassis at a chassis attachment bond and positioned in one of the first or second waist regions. The ultrasonically bonded, gathered laminate also includes an ear structural feature comprising a surface modification to the substrate and comprising at least one of the following: embossing, apertures, perforations, slits, melted material or coatings, compressed material, secondary bonds that are disposed apart from a chassis attachment bond, plastic deformation, and folds.

Abstract: Provided is a process including: obtaining criteria to select plain-text values in a lower-trust database; selecting, based on the criteria, a first plain-text value; in response, determining a first reference value; storing the first plain-text value in a higher-trust database in a second entry identified by the first reference value; storing the first reference value in the first entry of the lower-trust database; selecting another instance of the first plain-text value stored requested to be stored in a third entry in the lower-trust database; and in response, storing the first reference value in the third entry.

Abstract: A supply charging device for a mobile device includes a supply power connector having a supply housing having a mating end at the front mated with a receive power connector of the mobile device along a mating axis. The supply power connector has a cable end at the bottom. A supply contact chamber is at the mating end and a supply cable chamber is at the cable end. The supply power connector includes supply power contacts and a data communication module at the mating end. The supply charging device includes a cable assembly extending from the cable end at the bottom of the supply housing. The supply power cables extend along cable axes oriented non-parallel to the mating axis.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: A footwear article includes (a) an upper having a tongue opening at a front thereof; (b) a gusseted tongue including a tongue panel positioned over the tongue opening and a pair of gussets attaching laterally opposite sides of the tongue panel to the upper; (c) a pair of tongue fasteners configured to selectively fasten and unfasten corresponding sides of the tongue panel to and from the upper; (d) a first lacing system on the upper and arranged for guiding lacing over the gusseted tongue and tongue fasteners when the sides of the tongue are fastened to the upper; and (e) a second lacing system on the tongue panel and arranged for guiding the lacing across the tongue panel clear of the tongue fasteners when the sides of the tongue panel are unfastened from the upper.

Abstract: A docking station for a medical device is described. In some examples, the docking station includes a frame and a base plate coupled to the frame. At least a portion of the base plate is coupled to a lower portion of the frame. In some examples, an electronic connector of the docking station is configured to couple to the medical device and to provide power to the medical device when the medical device is docked to the docking station. In some examples, a docking mechanism is coupled to an upper portion of the frame and configured to retain the medical device.