Abstract: The present invention is a packaging with one-way seal. The packaging with one-way seal contains a packaging body, a first fastening strip, and a second fastening strip. The packaging body comprises a package base, a package opening, a first package flap, and a second package flap. The package base and the package opening are positioned terminally opposite to each other along the packaging body. The first package flap and the second package flap are connected adjacent to the package opening, opposite to the package base. The package opening is positioned between the first package flap and the second package flap. The first fastening strip traverses along the first package flap. The second fastening strip traverses along the second package flap. The first fastening strip is operatively engaged to the second fastening strip, where the first fastening strip is configured to engage the second fastening strip to a sealed configuration.