Abstract: An engine comprises an air intake arrangement configured to receive air; a heat exchanger arrangement arranged downstream of the air intake arrangement, configured to cool the air, and comprising a plurality of heat exchanger modules; and one or more turbomachinery components configured to receive cooled air from the heat exchanger arrangement. The plurality of heat exchanger modules are arranged to be generally centred on and to be arranged along a longitudinal axis of the engine. At least one of the plurality of heat exchanger modules is arranged to at least partially overlap with at least one other one of the plurality of heat exchanger modules relative to the longitudinal axis of the engine.

Abstract: A stand-alone modular removable rudder system for watercraft having a rudder comprising a steering handle coupled to a quick release mechanism adapted to releasably secure said steering handle to said watercraft in proximity to the operator, said system further comprising, a rudder mount adapted to be coupled to the rear of the watercraft by a quick release mechanism adapted to releasably secure said rudder mount to said watercraft, said rudder being carried by a rudder support pivotal about said rudder mount and cables operatively connecting said steering handle to said rudder mount whereby the steering handle can be operated to steer the rudder.

Abstract: Uncured aqueous composition comprising surfactant and a blend of (a) a first sulfonated polyester having a glass transition temperature not greater than 75° C. that is not sulfonated polyethylene naphthalate, (b) a second, sulfonated polyester that is a sulfonated polyethylene naphthalate, (c) melamine-formaldehyde crosslinker, and (d) an epoxy silane coupling agent; and cured composition thereof. Compositions described herein are useful, for example, for making primed film for release liners applications.

Abstract: Provided herein are methods of transducing resting or non-activated T cells using CD4-targeted viral vectors.

Abstract: A vertical takeoff and landing vehicle which includes an allocation block that receives a set of desired forces or desired moments and a health metric associated with at least one of: (1) a motor controller or (2) a rotor that operates in a vertical takeoff and landing mode at least some of the time. A command signal is determined per a first manner that attempts to satisfy both the set of desired forces or desired moments and the health metric. If the command signal is unable to be determined in the first manner, a second manner is used that prioritizes flight control associated with one or more of a roll axis or a pitch axis over flight control associated with a yaw axis where the axes are mutually orthogonal. The command signal is output to the motor controller that controls the rotor using the command signal.

Abstract: Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.

Abstract: Provided herein are systems and methods for the automation of seed planting and analysis comprising automated planting of the seeds, germination, and analysis. The methods generally comprise conveying containers containing seeds to an automated seed planting station, wherein each container includes a machine-readable tag, planting at least some of the seeds in the container onto respective planting trays, wherein each planting tray includes a machine-readable tag, allowing the seeds to germinate, and analyzing the germinated seeds. The systems generally comprise a seed planting system and a planting verification and correction system. Also provided herein are backlit templates comprising a light source and a power interface configured to connect to a power source to power the light source.

Abstract: A method for detecting an amount of an analyte in a solution includes providing an assay chamber including an electrode positioned at a first end of the assay chamber and a capture molecule attached to the electrode via a linker. A solution including an analyte, a binding partner of the analyte, at least one electrochemically active agent, and a detecting probe having a signaling tag attached thereto may be provided to the assay chamber. An electrical signal may be applied to the electrode to change the pH of the solution in the area near the electrode. The analyte may bind to the capture molecule and to the detecting probe at the first end of the assay chamber at the new pH. A signal produced by the signaling tag at the first end of the assay chamber may be measured to calculate the amount of the analyte in the solution.

Abstract: A medical instrument includes cable pairs respectively wound around input spindles and connected to actuate degrees of freedom of an instrument shaft structure. The cables may connect so that rotating the input spindles actuates corresponding degrees of freedom. First pulleys in the instrument may receive first cables from the input spindles and redirect the first cables toward the instrument shaft, and second pulleys may receive second cables from the input spindles and redirect the second cables toward the instrument shaft. In one configuration, the first and second pulleys are respectively mounted at first and second levels, and the second pulleys redirect the second cables through the first level. Additionally or alternatively, one level of cables may cross while the other level of cables does not.

Abstract: Techniques are disclosed for systems and methods to provide docking assist for mobile structures. A docking assist system includes a logic device, one or more sensors, one or more actuators/controllers, and modules to interface with users, sensors, actuators, and/or other modules of a mobile structure. The logic device is adapted to receive docking assist parameters from a user interface for the mobile structure and perimeter sensor data from a perimeter ranging system mounted to the mobile structure. The logic device determines docking assist control signals based, at least in part, on the docking assist parameters and perimeter sensor data, and it then provides the docking assist control signals to a navigation control system for the mobile structure. Control signals may be displayed to a user and/or used to adjust a steering actuator, a propulsion system thrust, and/or other operational systems of the mobile structure.

Abstract: Photochromic article having first and second opposed major surfaces comprising a first, transparent layer having first and second opposed major surfaces, the first layer comprising thermoplastic, a second, transparent layer having first and second opposed major surfaces, the second layer comprising photochromic dye and amorphous copolyester, wherein the first major surface of the second layer is adjacent to the second major surface of the first layer, and a third layer having first and second opposed major surfaces, wherein the first major surface of the third layer is adjacent to the second major surface of the second layer. Embodiments of photochromic article described herein are useful, for example in eyewear, window films, security films, decorative films, electronic devices (i.e., having a display with a photochromic article).

Abstract: A target molecule detection method includes contacting oxidation and reduction electrodes with a solution having redox tags. The method further includes applying a first oxidation voltage pulse to the oxidation electrode when the solution does not contain the target molecules to obtain a first oxidation current profile, applying a second oxidation voltage pulse to the oxidation electrode when the solution contains the target molecules to obtain a second oxidation current profile, applying a first reduction voltage pulse to the reduction electrode when the solution does not contain the target molecules to obtain a first reduction current profile, and applying a second reduction voltage pulse to the reduction electrode when the solution contains the target molecules to obtain a second reduction current profile. The method also includes detecting the target molecules in response to one or more electrical properties of the first and second oxidation and reduction current profiles.

Abstract: Techniques are disclosed for systems and methods to provide graphical user interfaces for assisted and/or autonomous navigation for mobile structures. A navigation assist system includes a user interface for a mobile structure comprising a display and a logic device configured to communicate with the user interface and render a docking user interface on the display. The logic device is configured to monitor control signals for a navigation control system for the mobile structure and render the docking user interface based, at least in part, on the monitored control signals. The docking user interface includes a maneuvering guide with a mobile structure perimeter indicator, an obstruction map, and a translational thrust indicator configured to indicate a translational maneuvering thrust magnitude and direction relative to an orientation of the mobile structure perimeter indicator.

Abstract: A series of substituted imidazo[1,2-b][1,2,4]triazine derivatives of formula (I), being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

Abstract: A microelectronics package assembly and process of making same are disclosed. The flange has an upper surface and a first coating disposed on the upper surface of the flange. The insulator has a bottom surface for mounting onto the flange and an upper surface opposite the bottom surface. A second coating is disposed on the bottom surface of the insulator and a third coating disposed on the upper surface of the insulator. The first coating, the second coating, and the third coating each have a thickness of less than or equal to 1 micron. At least one of the first coating, the second coating, and the third coating is applied via at least one of physical vapor deposition, atomic deposition, or chemical deposition.

Abstract: The present disclosure provides copolymers prepared by polymerizing a first monomer comprising at least one C?C and/or at least one C?C; and a second monomer of Formula (B): wherein at least one first monomer and/or at least one second monomer comprises a latent-fluoride moiety (e.g., pentafluorophenyl). Upon contacting the copolymers with a nucleophile (e.g., a thiol) and/or a base, the latent-fluoride moiety may release fluoride ions, which may in turn degrade the copolymers by cleaving the O—Si bonds. The copolymers may be useful for drug delivery, or as degradable (e.g., biodegradable) polymers, adhesives, coatings, or structural materials.

Abstract: A mechanical assembly to precisely position large objects and align them to be joined with other objects with precision. The assembly does not require power to operate and can therefore be used in a variety of remote and harsh locations.

Abstract: Techniques for generating formatting tags for textual content obtained from a source electronic document are disclosed. A system parses a digital file to obtain information about characters in an electronic document. The system applies tags to text generated based on the textual content of the electronic document by creating segments of textually-consecutive characters and applying corresponding text formatting style tags to the segments. The system further identifies segments of text overlapping bounding boxes in the electronic document. The system generates textual content including a segment of text and a corresponding hyperlink associated with the segment of text. The system further generates textual content by selectively applying line breaks from the source electronic document in the textual content.