Abstract: In order to facilitate the entity resolution and entity activity tracking and indexing, systems and methods include receiving first source records from a first database and second source records from a record database. A candidate set of second source records is determined by a heuristic search in the set of second source records. A candidate pair feature vector associated with each candidate pair of first and second source records is generated. An entity matching machine learning model predicts matching first source records for each candidate second source record based on the respective candidate pair feature vector. An aggregate quantity associated with the matching first source records is aggregated from a quantity associated with each first source record, and a quantity index for each candidate second source record is determined based the aggregate quantities. Each quantity index is displayed to a user.

Abstract: The disclosed systems and methods provide a system for dynamically serving personalized content for presentation across computing devices of different guests in an online retail environment. A server system can: retrieve, from a data repository, a subset of predefined content stories having a predetermined activation status and guest purchase data for at least a portion of guests in the online retail environment, the guest purchase data indicating products each guest purchased, determine product embeddings for each story in the subset, each embedding indicating a product linked to the story, determine, based on applying a guest story similarity (GSS) model to the guest purchase data for each guest, a similarity score between the guest purchase data and the embeddings that indicates a likelihood the guest would purchase products embedded in the story, and serve a content story having a similarity score that satisfies one or more guest personalization criteria.

Abstract: A method for detecting an amount of an analyte in a solution includes providing an assay chamber including an electrode positioned at a first end of the assay chamber and a capture molecule attached to the electrode via a linker. A solution including an analyte, a binding partner of the analyte, at least one electrochemically active agent, and a detecting probe having a signaling tag attached thereto may be provided to the assay chamber. An electrical signal may be applied to the electrode to change the pH of the solution in the area near the electrode. The analyte may bind to the capture molecule and to the detecting probe at the first end of the assay chamber at the new pH. A signal produced by the signaling tag at the first end of the assay chamber may be measured to calculate the amount of the analyte in the solution.

Abstract: A lock adapter includes a first adapter arm and a second adapter arm. The first adapter arm has a first end which mating with a staple of a latch assembly, which, with a corresponding hasp, controls access to a structure. The first adapter arm also has second end configured for mating with the shackle of the lock. The second adapter arm also has a first end and a second end. The first end of the second adapter arm is configured for mating with the first end of the first adapter arm after the first end of the first adapter arm mates with the latch. The second end of the second adapter arm is configured for mating with the shackle of the lock. Upon the lock adapter mating with the staple and with the shackle of the lock, access to the structure via the latch assembly is inhibited.

Abstract: A method of fabricating a nanochannel including a funnel-like inlet structure is provided. The method includes providing a wafer including a substrate, a first layer deposited on the substrate, a stop layer deposited on the first layer, a sacrificial layer deposited on the stop layer, and a structuring layer deposited on the sacrificial layer. The stop layer, the sacrificial layer, and the structuring layer forming a layer stack defining a nanochannel etch. The method may additionally include forming an underetch and depositing a capping layer on the structural layer to seal the nanochannel. A protecting layer may be deposited on the capping layer to protect the availability of an etchant molecule. A microchannel etch may be formed in the layer stack adjacent to the nanochannel etch, and the sacrificial layer next to an opening of the nanochannel may be etched to form a funnel-like inlet structure.

Abstract: A pellet dispenser system reliably dispenses a pellet when appropriate and is easy to clean. The system includes a hopper having two chambers separated by a divider with a pellet passageway. A dispensing hole allows single pellets to pass into a pellet chute when a disc having one or more pellet holes is rotated by a motor. When a pellet is to be dispensed, such as when a lever is pressed, the disc is rotated within the hopper and carries a pellet in one of the pellet holes until the pellet hole reaches the dispensing hole, at which point the pellet passes through the dispensing hole and into the pellet chute. A beam may be directed through the pellet chute such that the beam is interrupted when a pellet passes through the pellet chute, allowing for verification that a pellet was dispensed.

Abstract: A system for sequencing a polynucleotide strand including a device with a layer stack on a silicon wafer. The layer stack may include a first electrode and a second electrode separated by a dielectric insulating layer and a nanohole drilled through the layer stack so that the first and second electrodes are rotationally arranged around the nanohole. A polynucleotide strand with at least one nucleotide and at least one electroactive label may be pulled through the nanohole. The system may additionally include a controller that may apply an electrical signal to the first and second electrodes, measure a current (I) as a function of an applied potential (V) when an electroactive label is guided through the nanohole of the device, and adjust an electrical voltage to pull the polynucleotide strand through the nanohole at a predetermined speed.

Abstract: The disclosure herein relates to a method of reducing background noise during integrity testing of membrane filter to increase sensitivity and more effectively disposition failing membrane filters.

Abstract: Methods and systems described enable automatic generation of a significant portion of or all of a clinical report (e.g., radiology report), using multimodal models trained on image and language data. Methods described can transform unstructured language and image information into findings, as well as an accurate and comprehensive clinical report, in a designated style (e.g., writing style). The methods and systems described thus significantly improve performance in generation and processing of clinical reports, in relation to time saved per clinical shift, dictation effort, medical billing, and other performance factors.

Abstract: A vehicle configured to operate in a normal steering mode and a differential steering mode is disclosed. The vehicle includes at least three wheels with the first and second wheels disposed on opposite sides of the vehicle. First and second motors, independently controllable by a motor control unit, drive the corresponding wheels. A steering shaft connects a steering mechanism for changing the angle of travel of at least one wheel to a steering wheel, when the vehicle operates in the normal steering mode. When the vehicle operates in a differential steering mode, a steering lock mechanism locks the at least one wheel in a fixed angle of travel, and a sensor senses the direction the steering wheel is turned. The motor controller causes the motor to rotate the first and second wheels at different rotational speeds to turn the vehicle the direction the steering wheel is turned.

Abstract: Fasteners to couple foamless cushions of intertwined or entangled polymeric strands and methods thereof. In a first embodiment of the fastener, it comprises a retainer portion that anchors the fastener in the polymeric strands of the cushions and a protruding portion that extends through the polymeric strands of the cushion to another fastener. The retainer portion may have a larger dimension, area, or cross-section area than the retainer portion such that it is inhibited from penetrating through the polymeric strands.

Abstract: In order to facilitate the entity resolution and entity activity tracking and indexing, systems and methods include receiving first source records from a first database and second source records from a record database. A candidate set of second source records is determined by a heuristic search in the set of second source records. A candidate pair feature vector associated with each candidate pair of first and second source records is generated. An entity matching machine learning model predicts matching first source records for each candidate second source record based on the respective candidate pair feature vector. An aggregate quantity associated with the matching first source records is aggregated from a quantity associated with each first source record, and a quantity index for each candidate second source record is determined based the aggregate quantities. Each quantity index is displayed to a user.

Abstract: Methods and systems described enable automatic generation of a significant portion of or all of a clinical report (e.g., radiology report), using multimodal models trained on image and language data. Methods described can transform unstructured language and image information into findings, as well as an accurate and comprehensive clinical report, in a designated style (e.g., writing style). The methods and systems described thus significantly improve performance in generation and processing of clinical reports, in relation to time saved per clinical shift, dictation effort, medical billing, and other performance factors.

Abstract: Systems, devices, and methods for nucleic acid sequencing are provided. A dielectric member with multiple attached translocating proteins positioned between a first and a second electrode creates a sensing zone allowing an electroactive molecule to interact with both electrodes to complete an electrical circuit. Each of the multiple proteins captures a polynucleotide strand, brings the polynucleotide strand within the sensing zone, and translocates the polynucleotide strand across the sensing zone at a constant rate one nucleotide at a time. Directing current through the first electrode and the second electrode and holding the first electrode at a first voltage and the second electrode at a second voltage enables electron transfer via an electroactive label covalently bonded to a nucleotide. Current versus time measurements of the first electrode and of the second electrode are detected to determine when a nucleotide with an electroactive label is within the sensing zone.

Abstract: A method for producing a sensor unit for nucleic acid analysis having a first electrode and a second electrode in a nanochannel, the method includes arranging a main direction of extension of the nanochannel at an angle ? from about 70° to about 110° to a direction of extension of edges of exposed surface portions of the first and second electrodes.

Abstract: Systems and methods for nucleic acid sequencing are provided. Polynucleotide strands to be sequenced are immobilized to a surface, clonally amplified and primed for polynucleotide synthesis. Nucleotides modified with cleavable electroactive labels at the 3?-OH of the sugar ring are provided and are incorporated into the growing strand during synthesis. The labels of nucleotides that are successfully incorporated into the growing polynucleotide strand are cleaved via application of a stimulus after incorporation and are detected by an electronic nanosensor. The systems and methods described herein combine the high accuracy of SbS methods combined with the scalability and speed of semiconductor-based electrical detection mechanisms.

Abstract: The disclosed systems and methods provide a system for dynamically serving personalized content for presentation across computing devices of different guests in an online retail environment. A server system can: retrieve, from a data repository, a subset of predefined content stories having a predetermined activation status and guest purchase data for at least a portion of guests in the online retail environment, the guest purchase data indicating products each guest purchased, determine product embeddings for each story in the subset, each embedding indicating a product linked to the story, determine, based on applying a guest story similarity (GSS) model to the guest purchase data for each guest, a similarity score between the guest purchase data and the embeddings that indicates a likelihood the guest would purchase products embedded in the story, and serve a content story having a similarity score that satisfies one or more guest personalization criteria.

Abstract: Systems and methods to detect a polynucleotide strand in a sample during the early stage of amplification cycles. A metal-insulator-metal (MIM) electrode unit with two metal electrodes separated by a dielectric layer may be utilized as a nanogap sensor. Primers for amplifying a target polynucleotide strand may be immobilized on the surface of the dielectric layer. Polymerases, nucleotides, templates and primers may be added to the sample. At least one type of nucleotide may be labeled with a redox label that may enhance electron transport through the nanogap via tunneling and/or diffusion-based redox cycles. Signals (e.g., voltage pulses) may be directed through each of the electrodes. Current values from each electrode may be measured to establish a baseline signal. Alterations in the baseline signal may indicate the presence of target polynucleotide strands. The time to detect an alteration in the baseline signal may facilitate quantification of target polynucleotide strands.

Abstract: A method for the computer-assisted implementation of radiology recommendations includes any or all of: receiving a set of inputs; determining and/or identifying a set of findings; determining a set of follow-up recommendations; and triggering a set of outputs and/or actions based on the set of follow-up recommendations. A system for the computer-assisted implementation of radiology recommendations preferably includes and/or interfaces a set of computing subsystems and/or processing subsystems, but can additionally include and/or interface with a set of devices (e.g., user devices), models, and/or any other components.

Abstract: A nanoelectronic device includes first and second nano electrodes, a nanogap defined by the first and second nano electrodes and separating the first and second nano electrodes, a solvent present in the nanogap and including a plurality of redox molecules, and a component configured as a disruptor of solvent atomic structures, the component forming a surface portion on a bulk portion within the device, the component being located at a predetermined distance away from the first and second nano electrodes.