Abstract: A computer-implemented method for processing electronic medical images, the method including receiving a plurality of electronic medical images of a medical specimen correspond to a single subject. The plurality of electronic medical images may be inputted into to a trained machine learning system, the trained machine learning system being trained to compare each of the plurality of electronic medical images to each other to determine whether each pair of the electronic medical images matches within a predetermined similarity threshold. The trained machine learning system may output whether each pair of the electronic medical images matches within a predetermined similarity threshold. The output may be stored.

Abstract: A computer-implemented method for processing electronic medical images, the method including receiving a plurality of electronic medical images of a medical specimen. Each of the plurality of electronic medical images may be divided into a plurality of tiles. A plurality of sets of matching tiles may be determined, the tiles within each set corresponding to a given region of a plurality of regions of the medical specimen. For each tile of the plurality of sets of matching tiles, a blur score may be determined corresponding to a level of image blur of the tile. For each set of matching tiles, a tile may be determined with the blur score indicating the lowest level of blur. A composite electronic medical image, comprising a plurality of tiles from each set of matching tiles with the blur score indicating the lowest level of blur, may be determined and provided for display.

Abstract: Systems and methods are disclosed for identifying tissue specimen types present in digital whole slide images. In some aspects, tissue specimen types may be identified using unsupervised machine learning techniques for out-of-distribution detection. For example, a digital whole slide image of a tissue specimen and a recorded tissue specimen type for the digital whole slide image may be received. One or more feature vectors may be extracted from one or more foreground tiles of the digital whole slide image identified as including the tissue specimen, and a distribution learned by a machine learning system for the recorded tissue specimen type may be received. Using the distribution, a probability of the feature vectors corresponding to the recorded tissue specimen type may be computed and used as a basis for classifying the foreground tiles from which the feature vectors are extracted as an in-distribution foreground tile or an out-of-distribution foreground tile.

Abstract: Aspects disclosed herein may provide a computer-implemented method for processing electronic medical images. The method may include receiving one or more digital images of a pathology specimen, detecting a presence of one or more incidents of one or more attributes in the received digital image, detecting a spatial relationship of the one or more incidents, selecting, based on the detected spatial relationship, one or more incidents of the one or more attributes, and outputting, to a display, a visual depiction of the one or more selected incidents and the spatial relationship.

Abstract: Systems and methods are described herein for processing electronic medical images to determine a first machine learning system, the first machine learning system having been trained to identify regions of electronic medical images; receive a plurality of electronic medical images, each of the electronic medical images being associated with one or more subcategories; determine a subset of the plurality of electronic medical images that are associated with only one subcategory of the one or more subcategories; provide the subset of the plurality of electronic medical images to the first machine learning system, the first machine learning system identifying regions within the subset of the plurality of electronic medical images associated with the subcategory; and train a second machine learning system, using the identified regions and the subset of the plurality of electronic medical images.

Abstract: A computer-implemented method for processing medical images, the method may include receiving a plurality of medical images of at least one pathology specimen, the pathology specimen being associated with a patient. The method may further include receiving a gross description, the gross description comprising data about the medical images. The method may next include extracting data from the description. Next, the method may include determining, using a machine learning system, at least one associated location on the medical images for one or more pieces of data extracted. The method may then include outputting a visual indication of the gross description data displayed in relation to the medical images.

Abstract: Systems and methods are described herein for processing electronic medical images to predict one or more histological morphologies. For example, one or more digital medical images may be received, the one or more digital medical images being of at least one pathology specimen associated with a patient. Patient clinical data for the patient may be received. A trained machine learning system may be determined. The patient clinic data and one or more digital medical images may be provided to the trained machine learning system. A histological morphology prediction of the patient may be determined, using the trained machine learning system. The histological morphology prediction may be output to a user and/or storage.

Abstract: Systems and methods are disclosed for determining at least one geographic region of a plurality of geographic regions, at least one data variable, and/or at least one health variable, estimating a current prevalence of a data variable in a geographic region of the plurality of geographic regions, determining a trend in a relationship between the data variable and the geographic region at a current time, determining a second trend in the relationship between the data variable and the geographic region at at least one prior point in time, determining if the trend in the relationship is irregular within a predetermined threshold with respect to the second trend from the at least one prior point in time, and, upon determining that the trend in the relationship is irregular within a predetermined threshold, generating an alert.

Abstract: A computer-implemented method for processing an electronic image may include receiving, by an artificial intelligence (AI) system at an electronic storage of the AI system, one or more digital whole slide images (WSIs) and extracting one or more vectors of features from one or more foreground tiles of tile images of the one or more digital WSIs. The method may include running a trained machine learning model on the one or more vectors of features and determining, based on an output of the trained machine learning model, whether one or more quality issues are present in the one or more digital WSIs.

Abstract: Systems and methods are disclosed for identifying tissue specimen types present in digital whole slide images. In some aspects, tissue specimen types may be identified using unsupervised machine learning techniques for out-of-distribution detection. For example, a digital whole slide image of a tissue specimen and a recorded tissue specimen type for the digital whole slide image may be received. One or more feature vectors may be extracted from one or more foreground tiles of the digital whole slide image identified as including the tissue specimen, and a distribution learned by a machine learning system for the recorded tissue specimen type may be received. Using the distribution, a probability of the feature vectors corresponding to the recorded tissue specimen type may be computed and used as a basis for classifying the foreground tiles from which the feature vectors are extracted as an in-distribution foreground tile or an out-of-distribution foreground tile.

Abstract: Systems and methods are described herein for processing electronic medical images to predict one or more donor recipients for a patient. For example, a digital medical image of the patient may be received, wherein the patient is in need of a transplant. A trained machine learning system may be determined. The digital medical image may be provided into the trained machine learning system, the trained machine learning system determining a patient embedding. Using the patient embedding, a subset of donor recipients may be determined. Based on the subset of donor recipients a recommendation of optimal donors may be determined.

Abstract: Aspects disclosed herein may provide a computer-implemented method for processing electronic medical images. The method may include receiving one or more digital images of a pathology specimen, detecting a presence of one or more incidents of one or more attributes in the received digital image, detecting a spatial relationship of the one or more incidents, selecting, based on the detected spatial relationship, one or more incidents of the one or more attributes, and outputting, to a display, a visual depiction of the one or more selected incidents and the spatial relationship.

Abstract: Systems and methods are described herein for processing electronic medical images to determine a first machine learning system, the first machine learning system having been trained to identify regions of electronic medical images; receive a plurality of electronic medical images, each of the electronic medical images being associated with one or more subcategories; determine a subset of the plurality of electronic medical images that are associated with only one subcategory of the one or more subcategories; provide the subset of the plurality of electronic medical images to the first machine learning system, the first machine learning system identifying regions within the subset of the plurality of electronic medical images associated with the subcategory; and train a second machine learning system, using the identified regions and the subset of the plurality of electronic medical images.

Abstract: Systems and methods are disclosed for processing digital images to predict at least one continuous value comprising receiving one or more digital medical images, determining whether the one or more digital medical images includes at least one salient region, upon determining that the one or more digital medical images includes the at least one salient region, predicting, by a trained machine learning system, at least one continuous value corresponding to the at least one salient region, and outputting the at least one continuous value to an electronic storage device and/or display.

Abstract: A method for processing electronic images using uncertainty estimation may be used to determine whether to use an artificial intelligence (AI) assisted prediction. The method may include receiving one or more electronic images associated with a pathology specimen and providing the one or more electronic images to a machine learning model. The machine learning model may perform operations including determining a certainty level corresponding to a certainty that a predetermined AI system will provide an accurate prediction, determining whether the certainty level equals or exceeds a predetermined confidence threshold, and, upon determining that the certainty level does not equal or exceed a predetermined confidence threshold, determining to not use the predetermined AI system.

Abstract: A computer-implemented method for processing digital pathology images, the method including receiving a plurality of digital pathology images of at least one pathology specimen, the pathology specimen being associated with a patient. The method may further include determining, using a machine learning system, whether artifacts or objects of interest are present on the digital pathology images. Once the machine learning system has determined that an artifact or object of interest is present, the system may determine one or more regions on the digital pathology images that contain artifacts or objects of interest. Once the system determines the regions on the digital pathology images that contain artifacts or objects of interest, the system may use a machine learning system to inpaint or suppress the region and output the digital pathology images with the artifacts or objects of interest inpainted or suppressed.

Abstract: A method for filtering out artifacts from a digital pathology image of a tissue, the method comprising: determine a plurality of scores corresponding to a plurality of pixels in the digital pathology image of the tissue; group the plurality of pixels into a plurality of pixel clusters based on the plurality of scores corresponding to the plurality of pixels; identify, from the plurality of pixel clusters, one or more pixel clusters corresponding to one or more artifacts in the digital pathology image; and filter the digital pathology image by removing one or more regions in the digital pathology image corresponding to the one or more pixel clusters corresponding to the one or more artifacts.

Abstract: Systems and methods are disclosed for identifying formerly conjoined pieces of tissue in a specimen, comprising receiving one or more digital images associated with a pathology specimen, identifying a plurality of pieces of tissue by applying an instance segmentation system to the one or more digital images, the instance segmentation system having been generated by processing a plurality of training images, determining, using the instance segmentation system, a prediction of whether any of the plurality of pieces of tissue were formerly conjoined, and outputting at least one instance segmentation to a digital storage device and/or display, the instance segmentation comprising an indication of whether any of the plurality of pieces of tissue were formerly conjoined.

Abstract: A computer-implemented method for processing an electronic image may include receiving, by an artificial intelligence (AI) system at an electronic storage of the AI system, one or more digital whole slide images (WSIs) and extracting one or more vectors of features from one or more foreground tiles of tile images of the one or more digital WSIs. The method may include running a trained machine learning model on the one or more vectors of features and determining, based on an output of the trained machine learning model, whether one or more quality issues are present in the one or more digital WSIs.

Abstract: Systems and methods are disclosed for determining at least one geographic region of a plurality of geographic regions, at least one data variable, and/or at least one health variable, estimating a current prevalence of a data variable in a geographic region of the plurality of geographic regions, determining a trend in a relationship between the data variable and the geographic region at a current time, determining a second trend in the relationship between the data variable and the geographic region at at least one prior point in time, determining if the trend in the relationship is irregular within a predetermined threshold with respect to the second trend from the at least one prior point in time, and, upon determining that the trend in the relationship is irregular within a predetermined threshold, generating an alert.