Abstract: Delivery apparatus and methods for delivering a medical device into a patient's vasculature are disclosed. In some examples, a method includes inserting, into a patient, a distal end portion of a delivery apparatus including a radially compressed prosthetic valve mounted around a balloon, advancing the distal end through the patient's vasculature, and inflating the balloon to radially expand the prosthetic valve at a native heart valve. The delivery apparatus includes a handle, a first shaft and a second shaft extending from the handle, and a locking mechanism to prevent axial movement of the second shaft relative to first shaft. The second shaft extends coaxially through the first shaft and includes the balloon, the radially compressed prosthetic valve, and one or more radiopaque markers at a distal end portion. The first shaft includes an end piece covering a proximal portion of the balloon during the advancing of the delivery apparatus.

Abstract: The present disclosure provides a method of treating a fibrotic lung disease in a subject comprising administering to the subject an effective amount of a therapeutic agent, wherein the subject is asymptomatic and wherein the subject is at risk of developing the fibrotic lung disease.

Abstract: A hydrocarbon conversion process comprises pyrolysing at a temperature ?700° C. a feedstock comprising hydrocarbon to produce a pyrolysis effluent comprising at least one C2 to C4 olefin and C5+ aliphatic and aromatic hydrocarbons. The pyrolysis effluent is contacted with an oleaginous quench stream to reduce the temperature of the pyrolysis effluent to ?400° C. At least first and second streams are separated from the cooled effluent. The first stream comprises at least one C2 to C4 olefin, and the second stream comprises a quench oil having an average boiling point at atmospheric pressure of at least 120° C. At least a portion of the second stream is catalytically hydroprocessed to produce a hydroprocessed stream, which is combined with at least a portion of any remainder of the second stream to form the quench stream.

Abstract: A hydrocarbon conversion process comprises pyrolysing at a temperature ?700° C. a feedstock comprising hydrocarbon to produce a pyrolysis effluent comprising at least one C2 to C4 olefin and C5+ aliphatic and aromatic hydrocarbons. The pyrolysis effluent is contacted with an oleaginous quench stream to reduce the temperature of the pyrolysis effluent to ?400° C. At least first and second streams are separated from the cooled effluent. The first stream comprises at least one C2 to C4 olefin, and the second stream comprises a quench oil having an average boiling point at atmospheric pressure of at least 120° C. At least a portion of the second stream is catalytically hydroprocessed to produce a hydroprocessed stream, which is combined with at least a portion of any remainder of the second stream to form the quench stream.

Abstract: The present disclosure provides a method of treating a fibrotic lung disease in a subject comprising administering to the subject an effective amount of a therapeutic agent, wherein the subject is asymptomatic and wherein the subject is at risk of developing the fibrotic lung disease.

Abstract: A diester of a fused ring compound of the formula (I): wherein: the fused rings are both aromatic; R1 and R4 to R6 substituents are H or ester moieties having C1 to C20 linear or branched alkyl chains; R2 and R3 are —C(O)OCxHy, wherein x is from 10 to 12 and y is from 21 to 25; two adjacent R1 to R4 substituents are —C(O)OCxHy, wherein x is from 10 to 12 and y is from 21 to 25; and when R3 and R4 are ester moieties, the alkyl chains of R4 are not C5 or C8; and polymer compositions containing the fused ring compound.

Abstract: Aspects of the invention provide a process for upgrading a hydrocarbon feed. The process includes providing a hydrocarbon feed and a utility fluid. Then selectively extracting from the feed at least a portion of particulates to produce a raffinate and an extract. Third hydroprocessing at least a portion of the raffinate.

Abstract: Aspects of the invention provide a process for upgrading a hydrocarbon feed. The process includes providing a hydrocarbon feed and a utility fluid. Then selectively extracting from the feed at least a portion of particulates to produce a raffinate and an extract. Third hydroprocessing at least a portion of the raffinate.

Abstract: Aspects of the invention provide a process for upgrading a hydrocarbon feed. The process includes providing a hydrocarbon feed and a utility fluid. Then selectively extracting from the feed at least a portion of particulates to produce a raffinate and an extract. Third hydroprocessing at least a portion of the raffinate.

Abstract: A diester of a fused ring compound of the formula (I): wherein the R1 to R6 substituents are H or ester moieties having C1 to C20 alkyl chains, but when both fused rings are aromatic and R3 and R4 are ester moieties, the alkyl chains are not C5 or C8, and polymer compositions containing the fused ring compound.

Abstract: Provided are compounds and processes of making and using such compounds of the formula: Wherein R=C4 to C15 linear or branched alkyls wherein R is a linear or branched alkyl residue of a C4 to C15 alcohol. Such compounds provide advantageous properties when used as plasticizers in polymer compositions.

Abstract: Plasticizers of indane and or tetralin esters and blends thereof with thermoplastic polymers, such as PVC, are disclosed.

Abstract: Disclosed is a process for the conversion of acyclic C5 feedstock to a product comprising cyclic C5 compounds, such as for example, cyclopentadiene, and catalyst compositions for use in such process. The process comprising the steps of contacting said feedstock and, optionally, hydrogen under acyclic C5 conversion conditions in the presence of a catalyst composition to form said product. The catalyst composition comprising a microporous crystalline ferrosilicate, a Group 10 metal, and, optionally, a Group 11 metal, in combination with an optional Group 1 alkali metal and/or an optional Group 2 alkaline earth metal.

Abstract: The invention relates to a utility fluid, such as a fluid containing aromatic and non-aromatic ringed molecules, useful as a diluent when hydroprocessing pyrolysis tar, such as steam cracker tar. The specified utility fluid comprises ?10.0 wt % aromatic and non-aromatic ring compounds and each of the following: (a) ?1.0 wt % of 1.0 ring class compounds; (b) ?5.0 wt % of 1.5 ring class compounds; (c) ?5.0 wt % of 2.0 ring class compounds; and (d) ?0.1 wt % of 5.0 ring class compounds. The invention also relates to methods for producing such a utility fluid and to processes for hydroprocessing pyrolysis tar.

Abstract: The invention relates to methods and systems for treating heavy hydrocarbon by cavitation and hydroprocessing. The invention also relates to systems and methods for such treating, to equipment useful for such treating, and to cavitated, hydroprocessed products.

Abstract: Disclosed is a process for the conversion of acyclic C5 feedstock to a product comprising cyclic C5 compounds, such as for example, cyclopentadiene, and catalyst compositions for use in such process. The process comprising the steps of contacting said feedstock and, optionally, hydrogen under acyclic C5 conversion conditions in the presence of a catalyst composition to form said product. The catalyst composition comprising a microporous crystalline ferrosilicate, a Group 10 metal, and, optionally, a Group 11 metal, in combination with an optional Group 1 alkali metal and/or an optional Group 2 alkaline earth metal.

Abstract: The invention relates to a process for upgrading pyrolysis tar, such as steam cracker tar, in the presence of a utility fluid. The utility fluid contains 2-ring and/or 3-ring aromatics and has solubility blending number (SBN)?120. The invention also relates to the upgraded pyrolysis tar and to the use of the upgraded pyrolysis tar, for example, for fuel oil blending.

Abstract: Plasticizers of indane and or tetralin esters and blends thereof with thermoplastic polymers, such as PVC, are disclosed.

Abstract: The invention relates to methods and systems for treating heavy hydrocarbon by cavitation and hydroprocessing. The invention also relates to systems and methods for such treating, to equipment useful for such treating, and to cavitated, hydroprocessed products.

Abstract: The invention relates to a process for upgrading pyrolysis tar, such as steam cracker tar, in the presence of a utility fluid. The utility fluid contains 2-ring and/or 3-ring aromatics and has solubility blending number (SBN)?120. The invention also relates to the upgraded pyrolysis tar and to the use of the upgraded pyrolysis tar, for example, for fuel oil blending.