Abstract: A high voltage circuit breaker and disconnector for operation in air, extending along an axis, including an enclosure, the disconnector including a hollow current carrying conductor in the enclosure and extending along the axis. The conductor including at least one lower elongated slot and at least one upper elongated slot extending along the axis, each of the slots having a width w and a length l opening an air flow cross section. The ratio between the outer diameter surface of the hollow current carrying conductor and the total air flow cross section of all the slots in a same plane perpendicular to the axis being between 70 and 100.

Abstract: The invention relates to a method for producing a cushion for an orthopedic device, the cushion having a first component, which comprises a first film layer and a second film layer, and a second component that are joined with each other in such a way that there is at least one fluid-filled volume between the first component and the second component, the method comprising the following steps: inserting the first film layer, which has at least one opening, and the second film layer into a tool, which has an upper mold and a lower mold; applying a differential pressure to at least one of the film layers, so that the at least one film layer moves at least in sections towards the upper mold or the lower mold, thereby creating a distance between the two films; joining the two film layers along at least one connection line.

Abstract: The invention relates to a method for producing a cushion for an orthopedic device, the cushion having at least one fluid-filled volume, wherein the method includes compression molding of a three-dimensional first cushion component made of at least a first material, which is preferably elastic, in a mold that comprises an inner mold and an outer mold, and bonding the first cushion component to at least a second cushion component in such a way that the fluid-filled volume is created.

Abstract: The present application relates to a composition comprising (a) at least one immune checkpoint inhibitor and (b) at least one conjugate, wherein said conjugate is comprising (i) a target binding moiety, (ii) at least one amatoxin, and (iii) optionally at least one linker connecting said target binding moiety with said at least one amatoxin. The present application further relates to said composition for use in treating a patient having a cancer, and to a pharmaceutical formulation comprising said composition and additional excipients, as well as to methods of producing and using said composition (FIG. 1).

Abstract: The present invention relates to a composition comprising proteins identified in barn dust extract or peptides derived from one of the proteins. The composition is useful in the prevention or treatment of a disease.

Abstract: A radar module configured for plant monitoring is provided, including: a microwave chip including a radar signal source configured to generate a radar signal; a coupling element connected to the radar signal source by a signal link; and a resonant cavity into which the coupling element projects, the coupling element being configured to couple the radar signal into the resonant cavity, and the resonant cavity being integrated in the microwave chip.

Abstract: A vibration damper with at least two absorbers, each having at least one spoke spring, enables efficient damping of the frequency response of a crankshaft. The absorbers preferably have different natural frequencies that are adapted to the frequency response of the crankshaft. The absorbers exhibit a frequency response, which is not or only insignificantly dependent on aging of the spoke springs and on the ambient temperature. The corresponding vibration dampers can be easily designed and mounted.

Abstract: A method for monitoring a vehicle (1) having a vehicle superstructure (2), a chassis (3) connected to the vehicle superstructure (2), and a monitoring unit (11) which monitors the chassis (3) for damage. In the event that chassis damage is detected, the monitoring unit produces a warning signal (S) by means of a warning signal generator, where the warning signal generator has at least one drive unit (10) by means of which the warning signal (S) is produced in the form of a tactile mechanical vibration.

Abstract: A connection device for electrically connecting a plurality of first electrical components to a second electrical component and for arrangement on a first housing of the second component. In the interior at least one first and one second potential connection are arranged. The connection device includes a connection strip, which on a first side has a plurality of electrical plug-in connection units for respective electrical connection of one of the first components by a respective plug-in connection and a second opposite side relative to a first direction, for arrangement on a first component, a contacting unit which has a carrier for arrangement on a through opening of the first housing and at least one contact pair arranged on the carrier for electrically contacting the first and second potential connection.

Abstract: This application relates to amatoxin analogs in which the trans-4-substituent on the proline residue of the amatoxin is an R group other than a hydroxy, constructs comprising such amatoxin analogs coupled to a linker and conjugates comprising such amatoxin analog-linker constructs conjugated to a target moiety. The application also relates to uses of such amatoxin analogs, for example, in treatment of cancer.

Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention relates to a method for determining a turning radius of a trailer attached to a towing vehicle and moved by the latter, comprising a computing unit, which is connected to a measuring sensor system, which transmits sensor data about current movements of the trailer to the computing unit, and which sensor data is considered by the computing unit for the determination of the turning radius. The invention also relates to a trailer, which is equipped with a device, which uses a method of this type.

Abstract: A decorative device which includes at least one controllable winch (8) which is intended for unwinding and winding up an elongated non-rigid element (4), and the elongated non-rigid element (4) is connected to a respective burner (11) at one end (6) and to the at least one winch (8) at the other end (7), and the burner (11) can be moved down towards the floor (1) and up away from the floor (1) with the unwinding and winding up of the elongated non-rigid element (4), characterised in that the burner (11) can be ignited to generate a flame by means of an igniter via a controller (9) arranged outside the burner (11).

Abstract: A vibration damper with at least two absorbers, each having at least one spoke spring, enables efficient damping of the frequency response of a crankshaft. The absorbers preferably have different natural frequencies that are adapted to the frequency response of the crankshaft. The absorbers exhibit a frequency response, which is not or only insignificantly dependent on aging of the spoke springs and on the ambient temperature. The corresponding vibration dampers can be easily designed and mounted.

Abstract: A couch top extension includes a first section and a second section extending from the first section. The first section has a varying shape profile and the second section has a substantially uniform shape profile. A couch top extension includes an extension board comprising one or more identifiers capable of providing a detectable signal indicative of an identification of the extension board.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: The invention is directed to ion-capture compositions for ingestion and methods of use thereof. An aspect of the invention is drawn towards a method for selectively capturing at least one ion from the digestive system of a subject, the method comprising administering orally to the subject the ion-capture composition.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.