Abstract: The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer and other disorders and diseases. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues.

Abstract: A method and device for developing. a geometry of a superstructure and/or mesostructure for dental prostheses. According to one aspect of the invention a method of developing a geometry of a mesostructure for a dental prosthesis includes the following steps: receiving first 3D data defining a 3D installation space for a mesostructure, receiving second 3D data defining possible positions for attaching the mesostructure, receiving third 3D data defining possible positions or regions for attaching the dental prosthesis to the mesostructure, and developing an optimized geometry of the mesostructure by means of an optimization technique, wherein starting from the 3D installation space the possible positions for attaching the mesostructure and the possible positions or regions for attaching the dental prosthesis to the mesostructure, the geometry of the mesostructure is optimized by means of applying the physical laws.

Abstract: Embodiments in accordance with the present invention provide for the use of polycycloolefins in electronic devices and more specifically to the use of such polycycloolefins as gate insulator layers used in the fabrication of electronic devices, the electronic devices that encompass such polycycloolefin gate insulator and processes for preparing such polycycloolefin gate insulator layers and electronic devices encompassing such layers.

Abstract: Embodiments in accordance with the present invention provide for the use of polycycloolefins in electronic devices and more specifically to the use of such polycycloolefins as interlayers applied to fluoropolymer layers used in the fabrication of electronic devices, the electronic devices that encompass such polycycloolefin interlayers and processes for preparing such polycycloolefin interlayers and electronic devices.

Abstract: The invention relates to an internal combustion engine having an adjustable variable compression ratio, a crankshaft having a crankshaft center line and at least one counterweight, which has an extent with a maximum distance from the crankshaft center line, at least one connecting rod, an adjusting mechanism for adjusting the adjustable variable compression ratio, a switchover element for switching the adjusting mechanism, wherein the switchover element is arranged on the connecting rod, and an actuating element for switching over the switchover element from a first position, which corresponds to a first compression ratio, into a second position.

Abstract: A sensor module for integration within a seat assembly is provided. The sensor module comprises a temperature and/or humidity sensor (21) and a separate sensor support (51) for mechanically supporting said temperature and/or humidity sensor. The sensor support is configured to be arranged on or in a support layer below an air-permeable cover of the seat assembly.

Abstract: The present invention relates to a process for producing nylon-6,6 by a) providing a muconic acid starting material selected from muconic acid, esters of muconic acid, lactones of muconic acid and mixtures thereof, b) subjecting the muconic acid starting material provided in step a) at least to some extent to a reaction with hydrogen in the presence of at least one hydrogenation catalyst Hb) to give adipic acid, c1) subjecting the muconic acid starting material provided in step a) to some extent to a reaction with hydrogen in the presence of at least one hydrogenation catalyst Hc1) to give 1,6-hexanediol, or c2) subjecting the adipic acid obtained in step b) to some extent to a reaction with hydrogen in the presence of at least one hydrogenation catalyst Hc2) to give 1,6-hexanediol, d) subjecting the 1,6-hexanediol obtained in step c1) or c2) to amination in the presence of an amination catalyst to obtain hexamethylenediamine, e) subjecting the hexamethylenediamine obtained in step d) and at least a portion o

Abstract: The invention relates to a method for producing hexamethylenediamine, wherein a) a muconic acid starting material is provided, which is selected from among muconic acid, esters of muconic acid, lactones of muconic acid, and mixtures thereof, b) the muconic acid starting material is subjected to a reaction with hydrogen in the presence of at least one hydrogenation catalyst in order to form 1,6-hexanediol, and c) the 1,6-hexanediol obtained in step b) is subjected to amination in the presence of an amination catalyst in order to obtain hexamethylenediamine. The invention further relates to hexamethylenediamine which can be produced by means of said method.

Abstract: The invention relates to a process for preparing hexane-1,6-diol, in which a) a muconic acid starting material is provided, selected from muconic acid, esters of muconic acid, lactones of muconic acid and mixtures thereof, b) the muconic acid starting material is subjected to a reaction with hydrogen in the presence of at least one hydrogenation catalyst to hexane-1,6-diol, and c) the output from the hydrogenation in step b) is subjected to a distillative separation to obtain hexane-1,6-diol.

Abstract: A lane assist system for a motor vehicle can be activated and deactivated and allows steering intervention on an axle by use of a superimposed steering system. The lane assist system, when activated, is designed to reduce the translation ratio of the superimposed steering system by a factor between 5 and 15.

Abstract: A recreational utility vehicle having an enclosure with a bottom wall and first and second side wall assemblies is provided. The first and second side wall assemblies and the bottom wall define an interior region. The vehicle further includes a first suspension assembly coupled directly to the first side wall assembly, having a first swing arm assembly with a first operational position in which a first portion of the bottom wall of the enclosure is at a predetermined distance from a ground level elevation. The first swing arm assembly has a second operational position in which the first portion of the bottom wall of the enclosure is at the ground level elevation. The vehicle further includes a second suspension assembly operably coupled directly to the second side wall assembly.

Abstract: Method of maneuvering a mobile mining machine including two or more self steered and optionally self propelled interconnected units being connected as train units over a respective articulating joint, said mobile mining machine having a forward and a backward direction, wherein in a tunnel following mode the method includes: producing a set of first signals representative of sideward distances between at least one side of the mobile mining machine and a respective nearby wall of said tunnel, and—evaluating said set of first signals so as to determine a sideways position of the mobile mining machine in respect of the walls of said tunnel during driving, and—producing steering commands to be sent to a propulsion arrangement in order to maintain a position of the mobile mining machine to ensure clearance to tunnel walls during driving. The invention also relates to a system and a mobile mining machine.

Abstract: The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.

Abstract: A recreational utility vehicle having an enclosure with a bottom wall and first and second side wall assemblies is provided. The first and second side wall assemblies and the bottom wall define an interior region. The vehicle further includes a first suspension assembly coupled directly to the first side wall assembly, having a first swing arm assembly with a first operational position in which a first portion of the bottom wall of the enclosure is at a predetermined distance from a ground level elevation. The first swing arm assembly has a second operational position in which the first portion of the bottom wall of the enclosure is at the ground level elevation. The vehicle further includes a second suspension assembly operably coupled directly to the second side wall assembly.

Abstract: The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.

Abstract: The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer and other disorders and diseases. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: Embodiments in accordance with the present invention provide for the use of polycycloolefins in electronic devices and more specifically to the use of such polycycloolefins as gate insulator layers used in the fabrication of electronic devices, the electronic devices that encompass such polycycloolefin gate insulator and processes for preparing such polycycloolefin gate insulator layers and electronic devices encompassing such layers.

Abstract: A motor vehicle includes a plurality of actuators for carrying out movements of the chassis, wherein the motor vehicle includes a control device for determining orientation information describing an orientation of the chassis to be assumed with regard to at least one target setting, wherein the control device is designed to control the actuators on the basis of the orientation information in such a way that the actuators carry out in a combined manner pitching, rolling and vertical movements of the chassis in order to orient the chassis corresponding to the orientation described by the orientation information.

Abstract: Embodiments in accordance with the present invention provide for the use of polycycloolefins in electronic devices and more specifically to the use of such polycycloolefins as interlayers applied to fluoropolymer layers used in the fabrication of electronic devices, the electronic devices that encompass such polycycloolefin interlayers and processes for preparing such polycycloolefin interlayers and electronic devices.