Abstract: The invention relates to compositions comprising therapeutic antibodies, and uses and methods for increasing the potency of therapeutic antibodies. In particular, the invention provides a composition comprising (i) an agent which reduces Fc receptor binding of endogenous serum antibodies, and (ii) a therapeutic antibody, preferably a therapeutic antibody which is resistant to the agent. The therapeutic antibody may be administered to the subject after a set time interval, or the blood of the subject may be treated with the agent prior to administration of the therapeutic antibody.

Abstract: An apparatus includes a first waveguide core extending along a light-propagation direction and configured to receive light from a light source at a combined transverse electric (TE) mode and a transverse magnetic (TM) mode. A second waveguide core is spaced apart from the first waveguide core and is configured to couple light at a TM mode to the second waveguide core. A near-field transducer (NFT) is disposed at a media-facing surface of a write head, the NFT receiving the light from the first waveguide core or the second waveguide core and heating a magnetic recording medium in response thereto.

Abstract: Concepts for middleware in a web framework are presented. One example comprises defining a target object type configured to hold results of a middleware function. A first object for an application is received and a process of the middleware function is performed, using the first object, to generate a process result. Based on the process result, a second object of the target object type is generated, after which the second object is provided to the application.

Abstract: A process and system for microwave cooking food products with humidified air control.

Abstract: Wave based signals such as radio transmissions are susceptible to frequency alterations caused by the relative movement between a transmitter and a receiver. In a satellite context, the radio signals emitted by a satellite based transmitter may take on a frequency higher or lower than the actual frequency at which they are generated depending on whether the satellite is moving toward or away from the receiver, respectively. By calculating the theoretical frequency shift (Doppler shift) that should occur if a signal travels directly from a satellite to a receiver, the actual frequency of the signal as received can be used to determine if the signal's integrity is sufficient or if it has been compromised by some sort of interference or malfunction.

Abstract: An apparatus includes an input coupler configured to receive light excited by a light source. A near-field transducer (NFT) is positioned at a media-facing surface of a write head. A layered waveguide is positioned between the input coupler and the NFT and configured to receive the light output from the input coupler in a transverse electric (TE) mode and deliver the light to the NFT in a transverse magnetic (TM) mode. The layered waveguide comprises a first layer extending along a light-propagation direction. The first layer is configured to receive light from the input coupler. The first layer tapers from a first cross track width to a second cross track width where the second cross track width is narrower than the first cross track width. The layered waveguide includes a second layer that is disposed on the first layer. The second layer has a cross sectional area in a plane perpendicular to the light propagation direction that increases along the light propagation direction.

Abstract: Determination of one or more timing (phase) and/or frequency corrections to be made to a local time base of a receiver device to synchronize the local time base with the time of GPS or other highly accurate time base. Timing packets from one or more grandmaster devices whose time bases are substantially the same as that of GPS or the like and/or positioning system signals (e.g., GPS signals) directly from a positioning system are received and manipulated to determine the timing and/or frequency corrections. The corrected time base may be used to assist in acquiring such positioning signals to allow for higher accuracy correction and/or for downstream communication operation. The present utilities are advantageous such as when a sufficient number of channels (e.g., four) from the receiver device to positioning system satellites are unavailable to synchronize the local time base to the GPS or other accurate time base.

Abstract: An apparatus includes a first waveguide core extending along a light-propagation direction and configured to receive light from a light source at a combined transverse electric (TE) mode and a transverse magnetic (TM) mode. A second waveguide core is spaced apart from the first waveguide core and is configured to couple light at a TM mode to the second waveguide core. A near-field transducer (NFT) is disposed at a media-facing surface of a write head, the NFT receiving the light from the first waveguide core or the second waveguide core and heating a magnetic recording medium in response thereto.

Abstract: A recording head has a waveguide core with an input end proximate an energy source at an input surface of the recording head. The waveguide core couples light from the energy source to a near-field transducer that heats a recording medium in response to the light. An input coupler extends along the waveguide core from the input end to a termination region that is away from the input end in a light propagation direction. The input coupler has a first refractive index between that of the waveguide core and a surrounding material. The input coupler is wider than the waveguide core and has a slanted edge at the termination region. The slanted edge crosses the waveguide core such that the input coupler narrows to a neck away from the waveguide core in a crosstrack direction.

Abstract: A recording head has a waveguide core with an input end proximate an energy source at an input surface of the recording head. The waveguide core couples light from the energy source to a near-field transducer that heats a recording medium in response to the light. An input coupler extends along the waveguide core from the input end to a termination region that is away from the input end in a light propagation direction. The input coupler has a first refractive index between that of the waveguide core and a surrounding material. The input coupler is wider than the waveguide core and has a slanted edge at the termination region. The slanted edge crosses the waveguide core such that the input coupler narrows to a neck away from the waveguide core in a crosstrack direction.

Abstract: A computer-implemented method, computer program product and computing system for receiving a vehicle identifier concerning a vehicle passing through a tolling area that requires a toll payment; determining whether the vehicle identifier is locally-identifiably by a specific local entity; if the vehicle identifier is locally-identifiably by a specific local entity, locally-effectuating the toll payment concerning the tolling area via the specific local entity; and if the vehicle identifier is not locally-identifiably, providing the vehicle identifier to one or more remote entities to determine if the vehicle identifier is remotely-identifiably by a specific remote entity.

Abstract: A computer-implemented method, computer program product and computing system for receiving a vehicle identifier concerning a vehicle passing through a tolling area that requires a toll payment; providing the vehicle identifier to one or more local entities to determine whether the vehicle identifier is locally-identifiably by a specific local entity; if the vehicle identifier is locally-identifiably by a specific local entity, locally-effectuating the toll payment concerning the tolling area via the specific local entity; and memorializing the local effectuation of the toll payment concerning the tolling area via the specific local entity using distributed ledger technology.

Abstract: A computer-implemented method, computer program product and computing system for receiving a vehicle identifier concerning a vehicle passing through a tolling area that requires a toll payment; providing the vehicle identifier to one or more remote entities to determine whether the vehicle identifier is remotely-identifiably by a specific remote entity; and if the vehicle identifier is remotely-identifiably by a specific remote entity, remotely-effectuating the toll payment concerning the tolling area via the specific remote entity.

Abstract: An apparatus includes a first waveguide core extending along a light-propagation direction and configured to receive light from a light source at a combined transverse electric (TE) mode and a transverse magnetic (TM) mode. A second waveguide core is spaced apart from the first waveguide core and is configured to couple light at a TM mode to the second waveguide core. A near-field transducer (NFT) is disposed at a media-facing surface of a write head, the NFT receiving the light from the first waveguide core or the second waveguide core and heating a magnetic recording medium in response thereto.

Abstract: A real-time event processing system receives event data containing telemetric data and one or more personal identifiers. The personal identifier in the event data is replaced with an obfuscated value so that the telemetric data may be used without reference to the personal identifier. A reversible map is used to reverse the obfuscated personal identifier to its original value. In the case when a request is received to delete the mapped personal identifier, the link to the entry in the reversible map is broken by associating the personal identifier with a different obfuscated value.

Abstract: An implantable intravascular pressure sensor comprising a first transducer arranged to provide a pressure dependent signal in response to alternating electrical signals of a first frequency band, a second transducer arranged to provide a reference signal in response to alternating electrical signals of a second frequency band different from the first frequency band and an antenna coupling for sending and receiving said signals.

Abstract: An implantable intravascular device for deployment inside a human or animal, the apparatus comprising a body of crystalline material and a membrane of crystalline material fixed to the body by a hermetic bond an assembly of components carried on said crystalline material and arranged for responding to electrical signals wherein the body and the membrane at least partially encapsulate the assembly.

Abstract: An implantable device for deployment inside a human or animal body, the device comprising at least one sensing component arranged to respond to an electrical signal having a known frequency band and at least one antenna comprising at least one antenna pole connected to the at least one sensing component, the antenna pole comprising at least one helical coil and a connecting stem.

Abstract: The present disclosure describes measuring bending moments within a drillstring or tool string to identify deflections (or “dog-legs”) within the string. In some systems, the bending moments a plurality of strain gauges. In some such systems the strain gauges will be arranged in a selected spacing around the circumference of the tool string, in many examples, at a common plane extending generally perpendicular to the longitudinal axis of the string proximate the strain gauges. The bending moments may be further evaluated to provide a measure of wellbore tortuosity. For example, the bending moments may be utilized to define a radius of curvature associated with the determined bending moments, which may be further correlated with a directional measurement to apply a direction to the bending moment, and therefore to the tortuosity an any given location.

Abstract: A surface or bulk acoustic wave device can be implanted in or worn on a human or animal body to monitor various parameters thereof. The device comprises a pair of interdigitated transducers spaced apart over the surface of a piezo-electric substrate that is exposed to the parameter to be monitored. The device is interrogated by a radio-frequency signal being supplied to one of the transducers and detected after reflection by the other transducer. The parameter is measured by comparison of the supplied and received signals.