Patents by Inventor Christopher Thanos

Christopher Thanos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160257946
    Abstract: The invention provides methods and compositions for a mutein aminoacyl-tRNA synthetase that preferentially charges a tRNA with a non-natural amino acid. Also provided are methods for incorporating the non-natural amino acid, para-methylazido-L-phenylalanine into a protein and further conjugating a biologically active adduct to the para-methylazido-L-phenylalanine.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 8, 2016
    Inventors: Erik S. Zimmerman, Christopher Thanos
  • Publication number: 20160257945
    Abstract: The invention provides methods and compositions for a mutein aminoacyl-tRNA synthetase that preferentially charges a tRNA with a non-natural amino acid. Also provided are methods for incorporating the non-natural amino acids, pyridinyl-amino tetrazine amino acids, into a protein, and further conjugating a biologically active adduct to the pyridinyl-amino tetrazine.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 8, 2016
    Inventors: Erik S. Zimmerman, Christopher Thanos
  • Publication number: 20160201047
    Abstract: Nucleic acid molecules encoding modified factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Application
    Filed: March 29, 2016
    Publication date: July 14, 2016
    Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
  • Patent number: 9328339
    Abstract: Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: May 3, 2016
    Assignee: Catalyst Biosciences, Inc.
    Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
  • Patent number: 9145552
    Abstract: Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 29, 2015
    Assignee: Catalyst Biosciences, Inc.
    Inventors: Edwin L. Madison, Christopher Thanos
  • Publication number: 20140322191
    Abstract: Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Application
    Filed: May 1, 2014
    Publication date: October 30, 2014
    Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
  • Publication number: 20140242062
    Abstract: Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.
    Type: Application
    Filed: May 12, 2014
    Publication date: August 28, 2014
    Applicant: Catalyst Biosciences, Inc.
    Inventors: Edwin L. Madison, Jack Nguyen, Sandra Waugh Ruggles, Christopher Thanos
  • Publication number: 20140234290
    Abstract: Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.
    Type: Application
    Filed: April 3, 2014
    Publication date: August 21, 2014
    Inventors: Edwin L. Madison, Christopher Thanos
  • Patent number: 8778870
    Abstract: Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: July 15, 2014
    Assignee: Catalyst Biosciences, Inc.
    Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
  • Publication number: 20140044701
    Abstract: Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Application
    Filed: July 30, 2013
    Publication date: February 13, 2014
    Inventors: Edwin L. Madison, Christopher Thanos
  • Publication number: 20140030247
    Abstract: Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 30, 2014
    Inventors: Edwin L. Madison, Christopher Thanos
  • Patent number: 8524829
    Abstract: The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: September 3, 2013
    Assignee: Brown University Research Foundation
    Inventors: Edith Mathiowitz, Christopher Thanos, Zhi Liu
  • Patent number: 8519103
    Abstract: Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: August 27, 2013
    Assignee: Catalyst Biosciences, Inc.
    Inventors: Edwin L. Madison, Christopher Thanos
  • Publication number: 20130177541
    Abstract: Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Application
    Filed: November 3, 2011
    Publication date: July 11, 2013
    Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
  • Publication number: 20120308540
    Abstract: Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Application
    Filed: November 3, 2011
    Publication date: December 6, 2012
    Inventors: Edwin L. Madison, Christopher Thanos, Grant Ellsworth Blouse
  • Publication number: 20120244139
    Abstract: Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.
    Type: Application
    Filed: April 30, 2012
    Publication date: September 27, 2012
    Inventors: Edwin L. Madison, Jack Nguyen, Sandra Waugh Ruggles, Christopher Thanos
  • Patent number: 8129186
    Abstract: The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: March 6, 2012
    Assignee: Neurotrophincell Pty, Limited
    Inventors: Robert Bartlett Elliott, Stephen John Martin Skinner, Livia Del Carmen Escobar Orellana, Christopher Thanos
  • Publication number: 20110177025
    Abstract: The invention relates to methods and compositions for improving wound healing and in particular for preventing scar formation and thus loss of function that can occur in injured tissues during the natural wound healing process. Particularly, although by no means exclusively, the invention relates to the healing of chronic wounds such as diabetic ulcers.
    Type: Application
    Filed: July 15, 2009
    Publication date: July 21, 2011
    Inventors: Christopher Thanos, Briannan Bintz
  • Publication number: 20110166218
    Abstract: The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
    Type: Application
    Filed: June 17, 2008
    Publication date: July 7, 2011
    Inventors: Edith Mathiowitz, Christopher Thanos, Zhi Liu
  • Publication number: 20100166729
    Abstract: Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
    Type: Application
    Filed: April 11, 2008
    Publication date: July 1, 2010
    Inventors: Edwin L. Madison, Christopher Thanos, Sandra Waugh Ruggles, Shaun Coughlin