Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.

Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.

Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.

Abstract: A system and method for providing virtual items to users of an online game operated in a virtual space. Multiple users may participate in affiliations or alliances of discrete groups of users in an online game and may access the online game through client computing platforms associated with the users. The affiliations may have affiliation game units associated with affiliations which provide a benefit to the members of the online game. Affiliation members may cumulatively obtain affiliation game units and/or upgrade affiliation game units by providing one or more virtual items. Upgrading affiliation game units may require the cooperation of multiple members of the affiliation.

Abstract: A passive thermal diode (10), comprising: a heat source (12); a heat sink (14); a thermal coupling element (16) removably coupled to the heat source (12) and the heat sink (14); a lever (18), the lever (18) connected to the thermal coupling element (16) via a pivot point (19); and at least one spring (20) connected to the lever (18), the spring (20) comprised of a shape memory alloy, wherein the lever (18) transmits a force to displace the thermal coupling element (16) when the force is produced by the spring (20) on the lever (18).

Abstract: One aspect of the present disclosure relates to increasing an attribute of a virtual item type in a virtual space. Users, having virtual item instances of a virtual item, may be presented with an offer to increase a performance level of virtual item instances of the virtual item as a group in exchange for pooled consideration from the users as a group. The performance level of the virtual item instances of the virtual item may be increased as a group in exchange for the users, as a group, tendering the pooled consideration.

Abstract: A system and method for providing virtual items to users of an online game operated in a virtual space. Multiple users may participate in affiliations or alliances of discrete groups of users in an online game and may access the online game through client computing platforms associated with the users. The affiliations may have affiliation game units associated with affiliations which provide a benefit to the members of the online game. Affiliation members may cumulatively obtain affiliation game units and/or upgrade affiliation game units by providing one or more virtual items. Upgrading affiliation game units may require the cooperation of multiple members of the affiliation.

Abstract: A system and method for facilitating player interaction with instances of virtual containers in an online game are disclosed. After player activation of an instance of virtual container in the online game, one or more virtual items may be determined as initial payouts to be distributed to the player. One or more redetermined offers may be presented to the player such that the player may enable to pay an amount of consideration in exchange for having some or all of the items in the initial payout redetermined to improve the initial payout. Responsive to player selection of a redetermination offer, an outcome whether the player wins the reward may be determined stochastically. Distribution of virtual items may be effectuated accordance with the stochastically determined outcome.

Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.

Abstract: One aspect of the present disclosure relates to increasing an attribute of a virtual item type in a virtual space. Users, having virtual item instances of a virtual item, may be presented with an offer to increase a performance level of virtual item instances of the virtual item as a group in exchange for pooled consideration from the users as a group. The performance level of the virtual item instances of the virtual item may be increased as a group in exchange for the users, as a group, tendering the pooled consideration.

Abstract: A system and method for providing virtual items to users of an online game operated in a virtual space. Multiple users may participate in affiliations or alliances of discrete groups of users in an online game and may access the online game through client computing platforms associated with the users. The affiliations may have affiliation game units associated with affiliations which provide a benefit to the members of the online game. Affiliation members may cumulatively obtain affiliation game units and/or upgrade affiliation game units by providing one or more virtual items. Upgrading affiliation game units may require the cooperation of multiple members of the affiliation.

Abstract: A system and method for facilitating player interaction with instances of virtual containers in an online game are disclosed. After player activation of an instance of virtual container in the online game, one or more virtual items may be determined as initial payouts to be distributed to the player. One or more redetermination offers may be presented to the player such that the player may enable to pay an amount of consideration in exchange for having some or all of the items in the initial payout redetermined to improve the initial payout. Responsive to player selection of a redetermination offer, an outcome whether the player wins the reward may be determined stochastically. Distribution of virtual items may be effectuated in accordance with the stochastically determined outcome.

Abstract: A method and system for facilitating chance-based payment for items in a game. In implementations, the disclosure relates to such systems which can be used in the payment for items in an affiliation based game. A user may be part of an affiliation and wish to contribute to their affiliation and show their loyalty in a non-direct manner. The contribution may be achieved by the user entering into a chance-based selection process such as a draw, where the user selected in the draw is the person that pays for a group virtual item used in the game. The item used in the game may benefit all members of the affiliation, simultaneously or in alternating fashion.

Abstract: A system and method for providing virtual items to users of an online game operated in a virtual space. Multiple users may participate in affiliations or alliances of discrete groups of users in an online game and may access the online game through client computing platforms associated with the users. The affiliations may have affiliation game units associated with affiliations which provide a benefit to the members of the online game. Affiliation members may cumulatively obtain affiliation game units and/or upgrade affiliation game units by providing one or more virtual items. Upgrading affiliation game units may require the cooperation of multiple members of the affiliation.

Abstract: A system and method for facilitating resource requirement reduction in an online game are disclosed. Instances of resource requirement reduction items may be offered for purchase in an online store associated with the online game. A given resource requirement reduction item may be configured to reduce a type of game action requirements for game actions requested by a player during a corresponding time period subsequent to the activation of the instance of the resource requirement reduction item by the player. The player may activate a purchased instance of the requirement reduction item in the online game to reduce the game action requirements specified in the instance.

Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.

Abstract: A system and method for providing virtual items to users of an online game operated in a virtual space. Multiple users may participate in affiliations or alliances of discrete groups of users in an online game and may access the online game through client computing platforms associated with the users. The affiliations may have affiliation game units associated with affiliations which provide a benefit to the members of the online game. Affiliation members may cumulatively obtain affiliation game units and/or upgrade affiliation game units by providing one or more virtual items. Upgrading affiliation game units may require the cooperation of multiple members of the affiliation.

Abstract: A system and method for facilitating resource requirement reduction in an online game are disclosed. Instances of resource requirement reduction items may be offered for purchase in an online store associated with the online game. A given resource requirement reduction item may be configured to reduce a type of game action requirements for game actions requested by a player during a corresponding time period subsequent to the activation of the instance of the resource requirement reduction item by the player. The player may activate a purchased instance of the requirement reduction item in the online game to reduce the game action requirements specified in the instance.

Abstract: The present invention provides a bicycle comprising front and rear wheels and a frame including a main frame having a head tube and a top tube secured to the head tube at an intersection spaced from an upper end of the head tube. The intersection has a first lateral width, and the head tube above the intersection includes a tapered portion that tapers to a second lateral width narrower than the first lateral width. For example, the first lateral width can be at least three percent wider than the second lateral width. In one embodiment, the head tube above the tapered portion includes a flared portion that flares to a third lateral width wider (e.g., at least ten percent wider) than the second lateral width. In addition, the tapered portion can include a length that is larger (e.g., at least one hundred percent larger) than the second lateral width.