Patents by Inventor Chuan-Fa Liu

Chuan-Fa Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
    Patent number: 6756480
    Abstract: The present invention concerns therapeutic agents that modulate the activity of PTH and PTHrP. In accordance with the present invention, modulators of PTH and PTHrP comprise: (a) a PTH/PTHrP modulating domain; and (b) a vehicle, such as a polymer (e.g., PEG or dextran) or an Fc domain, which is preferred; wherein the vehicle is covalently attached to the C-terminus of the PTH/PTHrP modulating domain. The vehicle and the PTH/PTHrP modulating domain may be linked through the N- or C-terminus of the PTH/PTHrP modulating domain, as described further below. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain. Preferred PTH/PTHrP modulating domains comprise the PTH and PTHrP-derived amino acid sequences described hereinafter. Other PTH/PTHrP modulating domains can be generated by phage display, RNA-peptide screening and the other techniques mentioned herein.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: June 29, 2004
    Assignee: Amgen Inc.
    Inventors: Paul Kostenuik, Chuan-Fa Liu, David Lee Lacey
  • Modified peptides as therapeutic agents
    Publication number: 20040087778
    Abstract: The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides.
    Type: Application
    Filed: August 29, 2003
    Publication date: May 6, 2004
    Applicant: Amgen Inc.
    Inventors: Ulrich Feige, Chuan-Fa Liu, Janet C. Cheetham, Thomas Charles Boone
  • Modified peptides as therapeutic agents
    Publication number: 20040071712
    Abstract: The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides.
    Type: Application
    Filed: August 18, 2003
    Publication date: April 15, 2004
    Applicant: Amgen Inc.
    Inventors: Ulrich Feige, Chuan-Fa Liu, Janet C. Cheetham, Thomas Charles Boone
  • Modified peptides as therapeutic agents
    Publication number: 20040057953
    Abstract: The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 25, 2004
    Applicant: Amgen Inc.
    Inventors: Ulrich Feige, Chuan-Fa Liu, Janet C. Cheetham, Thomas Charles Boone
  • Modified peptides as therapeutic agents
    Publication number: 20040053845
    Abstract: The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides.
    Type: Application
    Filed: July 31, 2003
    Publication date: March 18, 2004
    Applicant: Amgen Inc.
    Inventors: Ulrich Feige, Chuan-Fa Liu, Janet C. Cheetham, Thomas Charles Boone
  • Modified peptides as therapeutic agents
    Publication number: 20040044188
    Abstract: The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides.
    Type: Application
    Filed: June 27, 2003
    Publication date: March 4, 2004
    Applicant: Amgen Inc.
    Inventors: Ulrich Feige, Chuan-Fa Liu, Janet C. Cheetham, Thomas Charles Boone
  • Modified peptides as therapeutic agents
    Patent number: 6660843
    Abstract: The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides. In this invention, pharmacologically active compounds are prepared by a process comprising: a) selecting at least one peptide that modulates the activity of a protein of interest; and b) preparing a pharmacologic agent comprising an Fc domain covalently linked to at least one amino acid of the selected peptide. Linkage to the vehicle increases the half-life of the peptide, which otherwise would be quickly degraded in vivo. The preferred vehicle is an Fc domain. The peptide is preferably selected by phage display, E. coli display, ribosome display, RNA-peptide screening, or chemical-peptide screening.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: December 9, 2003
    Assignee: Amgen Inc.
    Inventors: Ulrich Feige, Chuan-Fa Liu
  • Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
    Publication number: 20030039654
    Abstract: The present invention concerns therapeutic agents that modulate the activity of PTH and PTHrP.
    Type: Application
    Filed: April 26, 2001
    Publication date: February 27, 2003
    Applicant: Amgen Inc.
    Inventors: Paul Kostenuik, Chuan-Fa Liu, David Lee Lacey
  • Calcitonin-related molecules
    Publication number: 20020090646
    Abstract: The present invention concerns therapeutic agents that modulate the activity of CT receptor.
    Type: Application
    Filed: May 2, 2001
    Publication date: July 11, 2002
    Applicant: Amgen Inc.
    Inventors: Chuan-Fa Liu, William S. Marshall, Angela Reynolds