Abstract: The present invention relates to a N2,N4-diphenylpyrimidin-2,4-diamine derivative, a method for preparing the same, and a pharmaceutical composition for the prevention or treatment of cancer, containing the same as an active ingredient. The derivative shows a relatively weak EGFR activity inhibitory effect on wild-type EGFR, a high inhibitory ability on EGFR mutation, and a high inhibitory ability on even FLT3 and FLT3 mutation, and thus, can be effectively used for the treatment of cancer with EGFR mutation or cancer with FLT3 or a mutation thereof, and the derivative shows a synergy effect at the time of combination administration, and thus can be effectively used for the treatment of combination administration.

Abstract: A power transmission apparatus of a hybrid electric vehicle may include a first shaft fixedly connected to an engine, a second shaft selectively connectable to the first shaft and fixedly connected to a motor-generator, a third shaft disposed on a same axis with the first shaft and selectively connectable to the second shaft, a fourth shaft disposed coaxially with the third shaft without rotational interference therebetween, a fifth shaft disposed in parallel with the third and fourth shafts and externally gear-meshed with the third and fourth shafts, a planetary gear set having three elements, one element being fixedly connected to the second shaft, another element being selectively connectable to a transmission housing, and a remaining element being fixedly connected to the fourth shaft, and four gear sets forming gear engagements between the first shaft, the second shaft, the third shaft, the fourth shaft and the fifth shaft.

Abstract: A memory device in which reliability of a clock signal is improved is provided. The memory device comprises a data module including a clock signal generator configured to receive an internal clock signal from a buffer, and to generate a first internal clock signal, a second internal clock signal, a third internal clock signal, and a fourth internal clock signal having different phases, on the basis of the internal clock signal, and a first data signal generator configured to generate a first data signal on the basis of first data and the first internal clock signal, generate a second data signal on the basis of second data and the second internal clock signal, generate a third data signal on the basis of third data and the third internal clock signal, and generate a fourth data signal on the basis of fourth data and the fourth internal clock signal.

Abstract: A power transmission apparatus of a hybrid electric vehicle may include, a first shaft fixedly connected to an engine, a second shaft selectively connectable to the first shaft and fixedly connected to a motor-generator, a third shaft disposed on a same axis with the first shaft and selectively connectable to the second shaft, a fourth shaft disposed coaxially with the third shaft without rotational interference therebetween, a fifth shaft disposed in parallel with the third shaft and the fourth shaft and externally gear-meshed with the third shaft and the fourth shaft, a sixth shaft disposed in parallel with the third shaft and the fourth shaft and externally gear-meshed with the third shaft and the fourth shaft, a planetary gear set having three elements, one element being fixedly connected to the second shaft, another element being selectively connectable to a transmission housing, and a remaining element being fixedly connected to the fourth shaft, and four gear sets forming external gear engagements betw

Abstract: A memory device may include: a memory cell array including a plurality of planes; and a voltage generation circuit including a master pump component and at least one or more sub-pump components that respectively correspond to the planes. During an interleaved operation, the master pump component may generate a first output voltage in response to a first pump clock, and the sub-pump components may generate second output voltages in response to second pump clocks. The master pump component and the sub-pump components may respectively provide the first output voltage and the second output voltages to the corresponding planes. During a non-interleaved operation, the master pump component and the sub-pump components may generate the first output voltage in response to the first pump clock and provide the first output voltage to a selected plane of the plurality of planes.

Abstract: A power transmission apparatus of a hybrid vehicle using an engine and a motor-generator as a power source, includes a first shaft fixedly connected to an output side of the engine, a second shaft selectively connectable to the first shaft and fixedly connected to the motor-generator, a third shaft selectively connectable to the second shaft, a fourth shaft disposed without rotational interference in the external circumference of the third shaft, a fifth shaft externally geared with the third and fourth, a sixth shaft externally geared with the fourth shaft, a planetary gear set including first, second, and third rotation elements, and one of the three rotation elements is fixedly connected to the second shaft, the other rotation element is selectively connectable to a transmission housing, and the other rotation element is fixedly connected to the fourth, and four gear trains forming an external gear connection between the first, second, third, fourth, fifth and sixth shafts.

Abstract: A method for atomic layer etching may include a step of providing a substrate on which a material to be etched is formed, a modifying step of controlling the substrate at a first temperature and modifying a surface layer of the material to be removed by supplying a modifying gas to the substrate, and an etching step of controlling the substrate at a second temperature different from the first temperature and removing the modified surface layer by supplying an etching gas to the substrate.

Abstract: The present invention relates to a N2,N4-diphenylpyrimidin-2,4-diamine derivative, a method for preparing the same, and a pharmaceutical composition for the prevention or treatment of cancer, containing the same as an active ingredient. The derivative shows a relatively weak EGFR activity inhibitory effect on wild-type EGFR, a high inhibitory ability on EGFR mutation, and a high inhibitory ability on even FLT3 and FLT3 mutation, and thus, can be effectively used for the treatment of cancer with EGFR mutation or cancer with FLT3 or a mutation thereof, and the derivative shows a synergy effect at the time of combination administration, and thus can be effectively used for the treatment of combination administration.

Abstract: Provided herein is a memory device and a method of operating the same. The memory device may include a memory block, a voltage generation circuit configured to operate in a first mode in which an operating voltage is generated using an internal voltage or a second mode in which the operating voltage is generated using an external voltage, and to provide the operating voltage to the memory block, and a control logic configured to measure and store a first rising time during which the operating voltage rises to a target level in the first mode, and to control the voltage generation circuit so that a second rising time during which the operating voltage rises to the target level in the second mode is equal to or longer than the first rising time.

Abstract: The present technology includes a voltage generator and a memory device including the voltage generator. The voltage generator includes an operation code determiner configured to output a clock control code including the number of planes in response to an operation code, a clock group configured to simultaneously generate clocks having different periods according to the clock control code, and a pump group configured to perform a pumping operation according to the clocks and output operation voltages.

Abstract: The present technology includes a voltage generator and a memory device including the voltage generator. The voltage generator includes an operation code determiner configured to output a clock control code including the number of planes in response to an operation code, a clock group configured to simultaneously generate clocks having different periods according to the clock control code, and a pump group configured to perform a pumping operation according to the clocks and output operation voltages.

Abstract: An anammox reactor capable of improving nitrogen removal efficiency by maintaining activity of microorganisms, and a water treatment method using the anammox reactor are provided. The anammox reactor includes a raw water feed pipe through which raw water is supplied, a raw water discharge pipe through which raw water is discharged to an outside, and a first chamber configured to accommodate ammonium oxidizing bacteria (AOB) and anammox bacteria for performing an anammox process, wherein the raw water feed pipe and the raw water discharge pipe are configured to communicate with the first chamber.

Abstract: Disclosed is a sequencing batch reactor (SBR) for sewage treatment. The SBR is applicable to an energy-producing sewage treatment system. The SBR includes a treatment tank and a hybrid bacterial strain screening tank. The treatment tank removes ammonium contained in supernatant liquid using anaerobic ammonium-oxidizing (anammox) bacteria. The hybrid bacterial strain screening tank screen anammox bacteria granules out by passing the supernatant liquid discharged from the treatment tank through the hybrid bacterial strain screening tank. The SBR generates biogas using the anammox bacteria and reduces the nitrogen content in the supernatant liquid. The SBR can separate the anammox bacteria granules with high separation efficiency, thereby shortening sewage treatment time and recycling activated sludge, resulting in a dramatic decrease in the amount of waste sludge.

Abstract: A powertrain for an electric vehicle, may include: an input shaft and an output shaft mounted in parallel to each other; first and second power transmission mechanisms provided to transmit power from the input shaft to the output shaft at two gear ratios different from each other; a one-way clutch included in the first power transmission mechanism; a friction clutch included in the second power transmission mechanism; and a bypass mechanism provided to form a power transmission path that bypasses the one-way clutch and a power transmission path that bypasses the friction clutch.

Abstract: The present invention relates to an isoindolin-1-on derivative, a method for preparing same, and a pharmaceutical composition comprising same as an effective component for preventing or treating tumors, wherein the isoindolin-1-on derivative exhibits a high inhibitory effect on EGFR mutations, and thus can be beneficially used for the treatment of EGFR-mutated tumors, and the isoindolin-1-on derivative exhibits a significant synergistic effect when co-administered, and thus can be beneficially used in concomitant therapy.

Abstract: A system for optimizing project and/or task completion through the use of machine learning is disclosed. The system receives attributes for a project and participants to participate in the project. The attributes are provided to a natural language processing engine to determine content related to the attributes. Once the content is determined, the system receives a selection of a portion of the content and attributes to be searched via a search engine of the system. The search engine may then determine potential combinations of participants, such as individuals, devices, programs, and/or robots, which are suited to participate in the project. A selected combination of participants may perform the project. Feedback relating to the project may be utilized to adjust search algorithm variable weights and parameters utilized by the search engine to optimize the relevance of potential combinations of participants generated in response to a future search for a future project.

Abstract: Provided herein is a memory device and a method of operating the same. The memory device may include a memory block, a voltage generation circuit configured to operate in a first mode in which an operating voltage is generated using an internal voltage or a second mode in which the operating voltage is generated using an external voltage, and to provide the operating voltage to the memory block, and a control logic configured to measure and store a first rising time during which the operating voltage rises to a target level in the first mode, and to control the voltage generation circuit so that a second rising time during which the operating voltage rises to the target level in the second mode is equal to or longer than the first rising time.

Abstract: There is provided a method for enhancing immune function of an immune cell, and an immune cell line produced using the method. A method for enhancing immune function of an immune cell according to an exemplary embodiment of the present invention includes: treating immune cells with a PI3K inhibitor to activate AKT/mTOR downstream signal ex vivo; and culturing the immune cells treated with the PI3K inhibitor such that a lowered AKT level rebounds.

Abstract: A memory device may include: a memory cell array including a plurality of planes; and a voltage generation circuit including a master pump component and at least one or more sub-pump components that respectively correspond to the planes. During an interleaved operation, the master pump component may generate a first output voltage in response to a first pump clock, and the sub-pump components may generate second output voltages in response to second pump clocks. The master pump component and the sub-pump components may respectively provide the first output voltage and the second output voltages to the corresponding planes. During a non-interleaved operation, the master pump component and the sub-pump components may generate the first output voltage in response to the first pump clock and provide the first output voltage to a selected plane of the plurality of planes.

Abstract: An apparatus for supporting learning of a user is provided. The apparatus extracts, from a problem image, a first layout including textual information and a second layout including illustrative information, determines a first similarity between the first layout and textual information of a second problem stored, determines a second similarity between the second layout and illustrative information of the second problem, determines a third similarity between the first problem and the second problem by combining the first similarity and the second similarity, determines whether the second problem corresponds to the first problem, and transmits information indicating an answer or solution corresponding to the second problem to the user device.