Abstract: A method of calculating a collision risk of a ship according to an embodiment of the present disclosure may include: calculating an available velocity area based on maneuvering performance of a host ship; calculating a velocity obstacle area where there is a possibility of collision between an object and the host ship; and calculating a collision risk based on at least one of the available velocity area, the velocity obstacle area, and a preset weight.

Abstract: A method of inspecting a programmable logic controller (PLC) control logic using a graphic neural network (GNN) generally includes three operations: a data preprocessing operation for a GNN, an operation of predicting whether tags are connected, and an operation of verifying suitability of edge connections between tags. As a result, a graph is generated from a PLC control logic and input to a link prediction model to find an incorrect connection in the PLC control logic. Subsequently, a result graph output through the link prediction is input to a trained model to verify edge connection suitability between tags. Then, it may be finally verified whether tags are connected in the PLC control logic.

Abstract: The present invention relates to a composition for inhibiting biofilm comprising at least one selected from the group consisting of Lactobacillus rhamnosus, its culture medium, its extract and its cell-free supernatant and collagen hydrolysate. Although Lactobacillus rhamnosus can inhibit biofilm formation even as a single agent, the inhibitory ability is significantly increased when it is simultaneously treated with the collagen hydrolysate. The collagen hydrolysate inhibits acid production of Lactobacillus rhamnosus or Streptococcus mutans. Thus, the Lactobacillus rhamnosus and collagen hydrolysate can be usefully used as a composition for inhibiting the production of biofilms, in particular biofilms occurring in the oral cavity and a composition for preventing, alleviating, or treating oral diseases caused by the biofilms.

Abstract: The present invention relates to a method of manufacturing a dental composite blank, including (a) placing a composite paste in a mold, (b) pressurizing the composite paste placed in the mold at a first pressure (P1), (c) pressurizing the composite paste placed in the mold at a second pressure (P2), and (d) curing the pressurized composite paste, in which each of steps (b) and (c) is performed once or multiple times, and the first pressure (P1) is less than or greater than the second pressure (P2). The dental composite blank and the method of manufacturing the same are effective at dispersing a non-dispersed filler and removing bubbles, thus improving mechanical properties, through repeated pressurization at different pressures before curing the composite paste.

Abstract: The present invention relates to a natural fermented composition of pollen using glacial snow water obtained by mixing pollen, such as bee pollen, pollen, and edible flowers, with glacial snow water and fermenting same, and a preparation method therefor. In the present invention, provided is a composition obtained by mixing glacial snow water having a pH of 7.5 to 8.8 and a density of 0.05-0.85 g/cm3 with one or more kinds of pollens selected from bee pollen, pollen, flower buds, floral leaves, and floral nectaries and fermenting the mixture for three months or longer without inoculation of microorganisms. The natural fermented composition of the pollens of the present invention contains a wide variety of nutritional and active ingredients, and can exhibit various effects. Especially, since the composition has excellent antioxidative effects, the composition may be used for foods and beverages, antioxidant drinks, etc.

Abstract: The present disclosure discloses a method of generating a master state that is a normal state in a repeated cycle by analyzing log data output from a programmable logic controller (PLC). In addition, a method of generating log data as graph data as data preprocessing for generating a master state is disclosed. The method of generating a master pattern and the method of training a cycle analysis model according to the present disclosure are different from the related art in that the methods are a technology of processing a machine control language (low-level language) that is difficult for humans to analyze and converting the machine control language into an analyzable language (high-level language), i.e., a machine language processing (MLP)-based technology that analyzes the executed machine language (a language that controls a machine) with a computer and can be understood by humans.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: A manufacturing method of a semiconductor device may include: forming a stack comprising first material layers and second material layers that are alternately stacked; forming an opening in the stack; forming a first seed layer in the opening; forming a first buffer layer by surface-treating the first seed layer; and forming a blocking layer by oxidizing the first seed layer through the first buffer layer.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: Disclosed is a method and system for automatic establishment of an optimal schedule for a construction project. The disclosed method of automatic establishment of an optimal schedule for a construction project is a computer-implemented method of automatic establishment of an optimal schedule for a construction project, the method including: providing project data, standardized schedule data, and characteristic data (S10); generating project schedule data by combining the project data, the standardized schedule data, and the characteristic data (S20); and deriving an optimal project schedule by processing the project schedule data through a scheduling optimization algorithm (S30).

Abstract: A polyethylene glycol derivative compound is represented by Formula 1 described in the detailed description. In Formula 1, n is a natural number of 30 to 115, and R1 and R2 are C1 to C5 alkyl that are identical to or different from each other.

Abstract: The present invention relates to a method of manufacturing collagen for restoring cartilage tissue usable for a joint in an injection manner, and a usage method thereof. The present invention provides a method of obtaining a high-concentration collagen-solution injection by aseptically filling an injection container with collagen separated from pig skin tissue, and a method of using the high-viscosity collagen loaded into the injection container for the purpose of cartilage restoration. Cartilage tissue regeneration is effectively induced when tissue restoration is implemented with respect to a cartilage-deficient portion using collagen, which is a biocompatible material, in a form that is capable of being injected into an application site with an injection needle without a surgical incision. Accordingly, restoration and regeneration of cartilage are easily and quickly induced in an animal, excluding a human, while relieving the burden related to surgery.

Abstract: A steering wheel is provided. A steering wheel of a vehicle capable of autonomous driving includes a grip unit having a rim shape and held by a driver to steer the vehicle, an illumination unit provided in each of a left portion and a right portion of the grip unit in a circumferential direction of the grip unit, and a control unit configured to control the illumination unit to light up in a hold induction pattern for inducing holding by the driver according to a situation of the vehicle and a vehicle state pattern for guiding the driver through a state of the vehicle.

Abstract: Proposed is a method of manufacturing a dental composite blank. The method of manufacturing the dental composite blank includes (a) pressurizing a laminate for a composite blank having multiple layers having different colors at a first pressure (P1), (b) pressurizing the laminate for a composite blank, pressurized at the first pressure, at a second pressure (P2), and (c) manufacturing a composite blank by curing the pressurized laminate for a composite blank, in which steps (a) and (b) are each independently performed once or multiple times, and the first pressure (P1) is less than or greater than the second pressure (P2), ultimately making it possible to manufacture a dental composite blank that is similar to a natural tooth and thus exhibits a superior aesthetic appearance and high interlayer bonding strength.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: Disclosed is a medical material manufactured using collagen and a method of manufacturing the same. The method includes (1) preparing collagen using distilled water as a solvent, (2) filling a syringe with the prepared collagen and then spinning the collagen through a syringe needle, (3) immediately immersing the spun collagen in a cross-linking solution, which is a mixture including therein a hyperosmotic agent and a cross-linking agent mixed with each other, (4) removing and then washing the collagen after cross-linking is completed, and (5) removing and then drying the collagen after the washing is completed. When the collagen is spun and processed into the form of a thread and the spun thread is then cross-linked, the cross-linked collagen thread has increased strength compared to before cross-linking, and the shape thereof is retained in an aqueous solution.

Abstract: The present invention relates to a companion diagnosis biomarker composition and a companion diagnosis kit containing the same and, particularly, to a companion diagnosis biomarker composition for predicting a therapeutic response to at least one immune checkpoint inhibitor from among a PD-1 immune checkpoint inhibitor and a PD-L1 immune checkpoint inhibitor, and a companion diagnosis kit containing the same. According to the present invention, there is an effect that it is possible to predict a therapeutic response to at least one immune checkpoint inhibitor from among a PD-1 immune checkpoint inhibitor and a PD-L1 immune checkpoint inhibitor not only through a companion diagnosis through cancer patient tissues, but also through proteomic analysis of cancer patient blood.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: The present invention relates to an apparatus for diagnosing solid cancers comprising lung cancer, pancreatic cancer, bile duct cancer, colorectal cancer, breast cancer, gastric cancer, brain tumors, kidney cancer, liver cancer, and cervical cancer. More specifically, the apparatus comprises: a concentration measurement unit for measuring the concentration of each of acyl-carnitine (AC), nudifloramide (2PY), and lysophosphatidylcholine (LPC) from a biological sample; a pre-processing unit for pre-processing the measured concentrations; and a diagnosis unit for determining the diagnosis information of cancer through linear discriminant analysis using the pre-processed concentrations.

Abstract: An apparatus for extracting common command information from programmable logic controller (PLC) ladder information according to the present invention may include: a logic information extracting portion configured to extract control logic information from XML information converted from PLC ladder information; and a common command converting portion configured to convert the control logic information extracted by the logic information extracting portion into common command information, wherein the logic information extracting portion is configured to extract, from the XML information, the control logic information in the form of a block obtained by grouping units that respectively represent contacts and lines constituting the PLC ladder information according to an AND condition and an OR condition.