Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa. The disclosure relates to a particular class of compounds capable to activate TRPM8 ion channels. It further relates to the use of these compounds for inducing a sensation of coldness, and to consumer products comprising these compounds.

Abstract: The present invention provides lens testing equipment including a light source module, wherein the light source module includes a light guide mask and a light-emitting assembly. The light guide mask includes a light-transmitting plate body and a light-shielding pattern layer, wherein the light-shielding pattern layer is configured on the light-transmitting plate body, the light-shielding pattern layer includes multiple light-shielding line segments, and light-transmitting regions are formed among the light-shielding line segments. The light-emitting assembly is adapted to provide a light beam to pass through the light-transmitting regions of the light guide mask. The lens testing equipment of the present invention makes lens testing easier, and the lens testing equipment is simple in structure and easy to produce and has the advantage of low cost.

Abstract: An intelligent early screening model for Alzheimer's disease and a construction method thereof are provided. The construction method includes: retrieving keywords by means of a database to obtain influence factors of the Alzheimer's disease; extracting common feature data of Alzheimer's disease patients from big data in healthcare of a sample region; combining the influence factors and the common feature data, and then inputting into a machine learning model for learning; and verifying and evaluating performance of the machine learning model. The intelligent early screening model for the Alzheimer's disease is constructed through the construction method. The intelligent early screening model can capture Alzheimer's disease high-risk elderly population in common elderly population in advance, realizing early prevention and achieving a goal of eliminating the disease and treating the disease.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa. The disclosure relates to a particular class of compounds capable to activate TRPM8 ion channels. It further relates to the use of these compounds for inducing a sensation of coldness, and to consumer products comprising these compounds.

Abstract: Disclosed in the present invention are a method and apparatus for automatically improving printing effect, a device, and a storage medium. The method comprises: receiving an import request of a 3D model, and parsing a triangle patch comprised in the 3D model; acquiring all angular points of the 3D model according to the triangle patch, subtracting a minimum angular point from a maximum angular point to obtain a bounding box of the 3D model, creating, an axis perpendicular to the bounding box; using the axis and a platform inclination angle to calculate a quaternion related to the rotation of the 3D model; multiplying a space matrix of the bounding box of the 3D model by the rotation matrix enabling a printing path to be perpendicular to the bounding box. The model is imported to automatically keep the inclination angle consistent with a platform, thereby improving the printing effect.

Abstract: A 3D printer extrusion structure, comprising: a housing; a motor provided on the housing; an active extrusion gear provided in the housing and connected to the motor; an adjusting support rotatably connected inside the housing; a driven extrusion gear provided at one end of the adjusting support and rotatably connected to the adjusting support; and an elastic member, the elastic member being connected to an other end of the adjusting support to enable the end of the adjusting support provided with the driven extrusion gear to approach the active extrusion gear, so that the driven extrusion gear works in conjunction with the active extrusion gear to extrude material, wherein the end of the adjusting support provided with the driven extrusion gear extends to the outside of the housing.

Abstract: Disclosed are cyclopent-2-enone derivatives possessing woody odor profile with some peppery notes.

Abstract: The present disclosure provides antibody drug conjugates and drug-linker compounds comprising one or more degrader compounds which comprise a target protein binding moiety and an E3 ubiquitin ligase binding moiety that binds a Von Hippel-Lindau E3 Ubiquitin Ligase or a Cereblon E3 Ubiquitin Ligase, and methods of use thereof.

Abstract: A feed detection apparatus of a 3D printer, comprising a gear, a measurement device, a support, and a compression assembly. The gear is provided on the support to abut against a filament material, and rotates along with a movement of the filament material. The measurement device is placed on the support to measure a rotating speed of the gear, and determines a feeding status of the filament material according to a measurement result. The compression assembly comprises a connection member and an abutment member; the connection member is provided between the support and the abutment member; the abutment member is used for regulating a pressure of the connecting member applied on the support so as to enable the gear to abut against the filament material.

Abstract: A method of forming a semiconductor package includes the following operations. A semiconductor die is provided, wherein the semiconductor die includes die connectors protruding from a first side of the semiconductor die. A polymer layer is formed on the first side of the semiconductor die and covers the die connectors. The polymer layer is planarized until surfaces of the die connectors are exposed. The die connectors of the semiconductor die are bonded to interposer connectors of an interposer structure. An underfill layer is formed around the interposer connectors.

Abstract: The present invention relates to a 3D printing system. The 3D printing system comprises the rack, a release film replacement device, a light source assembly and a base assembly. The release film replacement device can replace a used release film. The light source assembly is arranged above the release film replacement device and is connected to the release film replacement device. The light source assembly is used for emitting light. The base assembly is arranged on the side of the release film replacement device away from the light source assembly. The base assembly is connected to the rack, and comprises a material container and a forming platform.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: The present invention relates to a release film replacing device, which comprises a winding assembly and a compression assembly. The winding assembly comprises a first reel and a second reel, wherein the first reel and the second reel are disposed opposite each other and are spaced apart from each other, both the first reel and the second reel are rotatably connected to a frame, the first reel winds up a first end of a release film, and the second reel winds up a second end of the release film. When the second reel is rotated about its own axis in a first direction, the first end of the release film can be unwound and the second end thereof can be wound.

Abstract: Sensing devices as well as methods of making and using the same. The sensing devices may include a pedestal (360,66,760) having a sensing element assembly (302) associated therewith and a port assembly (370,406,770) configured to mate with the pedestal (360,66,760). The port assembly (370,406,770) may include an axial passage (522) having a top portion (363) including an undercut feature (521,621,721) positioned to engage with a welded portion.

Abstract: A light source device and a 3D printing apparatus. The light source device includes an optomechanical assembly, a reflector assembly, and a workbench. The optomechanical assembly and the reflector assembly are spaced apart from each other in a first direction, and are located below the workbench. The optomechanical assembly can be rotated in a second direction, the reflector assembly can be rotated in a horizontal third direction, and the reflector assembly is configured to reflect, onto the workbench, a light ray emitted from the optomechanical assembly, wherein the first direction, the second direction and the horizontal third direction are pairwise perpendicular to each other.