Abstract: The present disclosure relates to the field of intelligent toilets and discloses a toilet seat and an intelligent toilet. The toilet seat comprises a toilet seat body and a connecting mechanism, wherein a rear end of the toilet seat body is rotatably connected to a surface of a toilet seat stand via the connecting mechanism; the toilet seat body comprises a seat face plate, a seat bottom plate and health detection sensors mounted on the seat face plate; the connecting mechanism is connected in a way that a gap is formed between the connecting mechanism and the toilet seat body, so as to allow the toilet seat body to move vertically with respect to the connecting mechanism and be supported on a top surface of the toilet seat by at least some of the health detection sensors when a human body is seated on the seat face plate.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: Provided is an air diffuser and a construction method thereof. The air diffuser is especially applied to the field of civil aircrafts. The air diffuser comprises: an open upper end part; an open lower end part; and an air flow passage defined between the open upper end part and the open lower end part, the air flow passage comprising a first side wall and a second side wall which are connected between the open upper end part and the open lower end part and are symmetrically located with respect to a vertical center plane of the air diffuser; wherein the section outline of each of the first side wall and the second side wall has a curved shape bending inwards, such that in a direction from the open upper end part to the open lower end part, the air flow passage has, in sequence, a contraction portion bending toward the vertical center plane and an expansion portion away from the vertical center plane.

Abstract: Techniques for determining parameters for a seed train process for growing a culture of cells. The techniques include obtaining a specification of seed train process constraints for multiple stages of the seed train process; determining the seed train process parameters using the seed train process constraints, the seed train process parameters comprising a respective set of parameters for each particular stage of multiple stages of the seed train process; determining, using historical cell growth data and the seed train process parameters, a likelihood indicative of whether performing the seed train process using the seed train process parameters will satisfy seed train process success criteria; and outputting the set of seed train process parameters for each stage of the multiple stages of the seed train process and the likelihood indicative of whether performing the seed train process will satisfy the seed train process success criteria.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: A semiconductor package provided herein includes an interposer substrate; a semiconductor die bonded to a first side of the interposer substrate; a first fill material layer having a through hole; and a conductive terminal disposed in the through hole, the conductive terminal including a first conductor portion, a second conductor portion and a third conductor portion, the first conductor portion being between the second conductor portion and the interposer substrate, and the second conductor portion being between the first conductor portion and the third conductor portion, wherein a boundary between the first conductor portion and the second conductor portion is located between opposite surfaces of the first fill material.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa. The disclosure relates to a particular class of compounds capable to activate TRPM8 ion channels. It further relates to the use of these compounds for inducing a sensation of coldness, and to consumer products comprising these compounds.

Abstract: The present invention provides lens testing equipment including a light source module, wherein the light source module includes a light guide mask and a light-emitting assembly. The light guide mask includes a light-transmitting plate body and a light-shielding pattern layer, wherein the light-shielding pattern layer is configured on the light-transmitting plate body, the light-shielding pattern layer includes multiple light-shielding line segments, and light-transmitting regions are formed among the light-shielding line segments. The light-emitting assembly is adapted to provide a light beam to pass through the light-transmitting regions of the light guide mask. The lens testing equipment of the present invention makes lens testing easier, and the lens testing equipment is simple in structure and easy to produce and has the advantage of low cost.

Abstract: An intelligent early screening model for Alzheimer's disease and a construction method thereof are provided. The construction method includes: retrieving keywords by means of a database to obtain influence factors of the Alzheimer's disease; extracting common feature data of Alzheimer's disease patients from big data in healthcare of a sample region; combining the influence factors and the common feature data, and then inputting into a machine learning model for learning; and verifying and evaluating performance of the machine learning model. The intelligent early screening model for the Alzheimer's disease is constructed through the construction method. The intelligent early screening model can capture Alzheimer's disease high-risk elderly population in common elderly population in advance, realizing early prevention and achieving a goal of eliminating the disease and treating the disease.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa. The disclosure relates to a particular class of compounds capable to activate TRPM8 ion channels. It further relates to the use of these compounds for inducing a sensation of coldness, and to consumer products comprising these compounds.