Abstract: Provided is an air diffuser and a construction method thereof. The air diffuser is especially applied to the field of civil aircrafts. The air diffuser comprises: an open upper end part; an open lower end part; and an air flow passage defined between the open upper end part and the open lower end part, the air flow passage comprising a first side wall and a second side wall which are connected between the open upper end part and the open lower end part and are symmetrically located with respect to a vertical center plane of the air diffuser; wherein the section outline of each of the first side wall and the second side wall has a curved shape bending inwards, such that in a direction from the open upper end part to the open lower end part, the air flow passage has, in sequence, a contraction portion bending toward the vertical center plane and an expansion portion away from the vertical center plane.

Abstract: Techniques for determining parameters for a seed train process for growing a culture of cells. The techniques include obtaining a specification of seed train process constraints for multiple stages of the seed train process; determining the seed train process parameters using the seed train process constraints, the seed train process parameters comprising a respective set of parameters for each particular stage of multiple stages of the seed train process; determining, using historical cell growth data and the seed train process parameters, a likelihood indicative of whether performing the seed train process using the seed train process parameters will satisfy seed train process success criteria; and outputting the set of seed train process parameters for each stage of the multiple stages of the seed train process and the likelihood indicative of whether performing the seed train process will satisfy the seed train process success criteria.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: A semiconductor package provided herein includes an interposer substrate; a semiconductor die bonded to a first side of the interposer substrate; a first fill material layer having a through hole; and a conductive terminal disposed in the through hole, the conductive terminal including a first conductor portion, a second conductor portion and a third conductor portion, the first conductor portion being between the second conductor portion and the interposer substrate, and the second conductor portion being between the first conductor portion and the third conductor portion, wherein a boundary between the first conductor portion and the second conductor portion is located between opposite surfaces of the first fill material.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa. The disclosure relates to a particular class of compounds capable to activate TRPM8 ion channels. It further relates to the use of these compounds for inducing a sensation of coldness, and to consumer products comprising these compounds.

Abstract: The present invention provides lens testing equipment including a light source module, wherein the light source module includes a light guide mask and a light-emitting assembly. The light guide mask includes a light-transmitting plate body and a light-shielding pattern layer, wherein the light-shielding pattern layer is configured on the light-transmitting plate body, the light-shielding pattern layer includes multiple light-shielding line segments, and light-transmitting regions are formed among the light-shielding line segments. The light-emitting assembly is adapted to provide a light beam to pass through the light-transmitting regions of the light guide mask. The lens testing equipment of the present invention makes lens testing easier, and the lens testing equipment is simple in structure and easy to produce and has the advantage of low cost.

Abstract: An intelligent early screening model for Alzheimer's disease and a construction method thereof are provided. The construction method includes: retrieving keywords by means of a database to obtain influence factors of the Alzheimer's disease; extracting common feature data of Alzheimer's disease patients from big data in healthcare of a sample region; combining the influence factors and the common feature data, and then inputting into a machine learning model for learning; and verifying and evaluating performance of the machine learning model. The intelligent early screening model for the Alzheimer's disease is constructed through the construction method. The intelligent early screening model can capture Alzheimer's disease high-risk elderly population in common elderly population in advance, realizing early prevention and achieving a goal of eliminating the disease and treating the disease.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa. The disclosure relates to a particular class of compounds capable to activate TRPM8 ion channels. It further relates to the use of these compounds for inducing a sensation of coldness, and to consumer products comprising these compounds.

Abstract: Disclosed in the present invention are a method and apparatus for automatically improving printing effect, a device, and a storage medium. The method comprises: receiving an import request of a 3D model, and parsing a triangle patch comprised in the 3D model; acquiring all angular points of the 3D model according to the triangle patch, subtracting a minimum angular point from a maximum angular point to obtain a bounding box of the 3D model, creating, an axis perpendicular to the bounding box; using the axis and a platform inclination angle to calculate a quaternion related to the rotation of the 3D model; multiplying a space matrix of the bounding box of the 3D model by the rotation matrix enabling a printing path to be perpendicular to the bounding box. The model is imported to automatically keep the inclination angle consistent with a platform, thereby improving the printing effect.

Abstract: A 3D printer extrusion structure, comprising: a housing; a motor provided on the housing; an active extrusion gear provided in the housing and connected to the motor; an adjusting support rotatably connected inside the housing; a driven extrusion gear provided at one end of the adjusting support and rotatably connected to the adjusting support; and an elastic member, the elastic member being connected to an other end of the adjusting support to enable the end of the adjusting support provided with the driven extrusion gear to approach the active extrusion gear, so that the driven extrusion gear works in conjunction with the active extrusion gear to extrude material, wherein the end of the adjusting support provided with the driven extrusion gear extends to the outside of the housing.

Abstract: Disclosed are cyclopent-2-enone derivatives possessing woody odor profile with some peppery notes.

Abstract: The present disclosure provides antibody drug conjugates and drug-linker compounds comprising one or more degrader compounds which comprise a target protein binding moiety and an E3 ubiquitin ligase binding moiety that binds a Von Hippel-Lindau E3 Ubiquitin Ligase or a Cereblon E3 Ubiquitin Ligase, and methods of use thereof.

Abstract: A feed detection apparatus of a 3D printer, comprising a gear, a measurement device, a support, and a compression assembly. The gear is provided on the support to abut against a filament material, and rotates along with a movement of the filament material. The measurement device is placed on the support to measure a rotating speed of the gear, and determines a feeding status of the filament material according to a measurement result. The compression assembly comprises a connection member and an abutment member; the connection member is provided between the support and the abutment member; the abutment member is used for regulating a pressure of the connecting member applied on the support so as to enable the gear to abut against the filament material.