Patents by Inventor Chung-Ming Hsieh

Chung-Ming Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250226745
    Abstract: A charge controller for a buck circuit is illustrated. The charge controller compares a reference voltage and multiple feedback voltages of multiple output voltages to generate multiple comparison signals, wherein a pulse-frequency modulation buck module outputs the output voltages at multiple voltage output terminals through a single inductor and multiple switches, and each of the switches is disposed between the single inductor and the corresponding voltage output terminal. Then, the charge controller determines a charging order of the voltage output terminals based on the comparison signals, and is arranged to generate multiple switching signals and a start signal based on a zero-current detection signal of the single inductor and the charging order, wherein the switching signals are arranged to control the switches, and the start signal is arranged to enable the pulse-frequency modulation buck module to charge one of the voltage output terminals.
    Type: Application
    Filed: August 1, 2024
    Publication date: July 10, 2025
    Inventors: YEH-TAI HUNG, CHUNG MING HSIEH
  • Patent number: 12334931
    Abstract: A signal conversion device for converting a single-ended input voltage into a differential input voltage having a positive input voltage and a negative input voltage is provided. During a sampling phase, a holding phase, and a common-mode voltage generation phase, a capacitor related to the positive input voltage is electrically connected to the single-ended input voltage, and a capacitor related to the negative input voltage is electrically connected to a preset voltage. During a single-ended to differential phase, the capacitor related to the positive input voltage is electrically connected to the preset voltage, and the capacitor related to the negative input voltage is electrically connected to the single-ended input voltage. Hence, the common-mode voltage is not related to a capacitance ratio, and the capacitors does not need to be designed as switching capacitors with multiple switches. No complex control is required, and the parasitic effect of the circuit can be reduced.
    Type: Grant
    Filed: November 30, 2023
    Date of Patent: June 17, 2025
    Assignee: NUVOTON TECHNOLOGY CORPORATION
    Inventors: Yeh-Tai Hung, Ching-Yen Chiu, Chung Ming Hsieh
  • Publication number: 20250181096
    Abstract: A digital DC-DC voltage conversion apparatus is used to convert an input voltage into an output voltage for a digital core circuit and generate an output current for the digital core circuit. The digital DC-DC voltage conversion apparatus includes a direct charging path current supply unit. The direct charging path current supply unit includes a direct charging switch and a direct charging path controller electrically connected to the direct charging switch. A control end of the direct charging switch receives a direct charging switch control signal, and the direct charging path controller generates direct charging switch control signal to control the direct charging switch to generate a direct charging path current to the digital core circuit. In this way, the digital DC-DC voltage conversion apparatus can faster track an operation current of the digital core circuit.
    Type: Application
    Filed: April 23, 2024
    Publication date: June 5, 2025
    Inventors: YEH-TAI HUNG, CHUNG MING HSIEH
  • Publication number: 20250163159
    Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
    Type: Application
    Filed: May 21, 2024
    Publication date: May 22, 2025
    Inventors: Edward B. Reilly, Andrew C. Phillips, Lorenzo Benatuil, Chung-Ming Hsieh, Jennifer Perez
  • Publication number: 20250036150
    Abstract: The present disclosure provides a digital low-dropout regulator (DLDO) and an electronic device using the same. The DLDO includes a voltage comparator circuit, a switch control circuit, a power switch module, and an asynchronous clock generation circuit. The voltage comparator circuit compares a reference voltage with the output voltage to output a comparison result signal. The switch control circuit generates a switch control signal based on the comparison result signal. The power switch module is controlled by the switch control signal to switch between the on state and the off state, thereby adjusting the output voltage. The asynchronous clock generation circuit generates a reference clock signal that is asynchronous with the system clock signal used in the load circuit and has a higher clock frequency. This allows the switch control circuit to update the switch control signal based on the reference clock signal.
    Type: Application
    Filed: November 30, 2023
    Publication date: January 30, 2025
    Inventors: YEH-TAI HUNG, CHUNG MING HSIEH
  • Publication number: 20250036364
    Abstract: An entropy maintaining method for a true random number generator and a true random number generator thereof are provided. The true random number generator includes a plurality of first ring oscillation output circuits. The entropy maintaining method includes providing at least one second ring oscillation output circuit in the true random number generator, the at least one second ring oscillation output circuit initially disabled; after the true random number generator is operated, recording logic of generated random bit signals every preset time; counting the logic of the random number bit signal to obtain a statistic value; and determining, according to the statistic value, whether the at least one second ring oscillation output circuit is operated in combination with the plurality of first ring oscillation output circuits to generate the random bit signals.
    Type: Application
    Filed: January 8, 2024
    Publication date: January 30, 2025
    Inventors: Hui-Chun KO, Chung Ming HSIEH
  • Publication number: 20250030409
    Abstract: A signal conversion device for converting a single-ended input voltage into a differential input voltage having a positive input voltage and a negative input voltage is provided. During a sampling phase, a holding phase, and a common-mode voltage generation phase, a capacitor related to the positive input voltage is electrically connected to the single-ended input voltage, and a capacitor related to the negative input voltage is electrically connected to a preset voltage. During a single-ended to differential phase, the capacitor related to the positive input voltage is electrically connected to the preset voltage, and the capacitor related to the negative input voltage is electrically connected to the single-ended input voltage. Hence, the common-mode voltage is not related to a capacitance ratio, and the capacitors does not need to be designed as switching capacitors with multiple switches. No complex control is required, and the parasitic effect of the circuit can be reduced.
    Type: Application
    Filed: November 30, 2023
    Publication date: January 23, 2025
    Inventors: YEH-TAI HUNG, CHING-YEN CHIU, CHUNG MING HSIEH
  • Patent number: 12200098
    Abstract: A power supply device is used to provide power to an encryption and decryption device of a security system, including a safety power supply device, which is used to supply the supply voltage according to the system voltage; a regulated voltage source, which is used to provide a regulated voltage; and a voltage selection device, which is electrically connected with the safety power supply device, the stable voltage source and the encryption and decryption device. During the startup period of the security system, or, after the startup period of the security system and the encryption/decryption device performs encryption/decryption, only the supply voltage is selected as the driving voltage of the encryption/decryption device. After the startup period of the security system and the encryption and decryption device does not perform encryption and decryption, the voltage only the regulated voltage is selected as the driving voltage of the encryption and decryption device.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: January 14, 2025
    Assignee: NUVOTON TECHNOLOGY CORPORATION
    Inventors: Po-Hsuan Huang, Chung Ming Hsieh
  • Patent number: 12176914
    Abstract: An embodiment of the present disclosure provides a conversion circuit for converting a single-ended input to a differential input, which has fewer switches and fewer capacitors. This conversion circuit increases the signal-to-noise ratio (SNR), and the conversion circuit directly uses the higher supply voltage AVDD without being bucked by the regulator, wherein the common mode voltage is AVDD/2N, and N is greater than 1. Overall, not only the circuit area is smaller and the SNR is higher, but also the manufacturing cost is reduced. In addition, compared with the prior art, the conversion circuit of the embodiment of the present disclosure has only three operation periods, so the control is simpler and the operation speed is faster.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: December 24, 2024
    Assignee: NUVOTON TECHNOLOGY CORPORATION
    Inventors: Yeh-Tai Hung, Wei-Chan Hsu, Chung Ming Hsieh
  • Publication number: 20240011016
    Abstract: A Saccharomyces cerevisiae antibody display system that simultaneously secrets and displays antibody fragments from a very large size synthetic nave human antibody library for therapeutic antibody lead discovery and engineering is described. A bait anchor complexed with a monovalent antibody fragment is tethered on the surface of the S. cerevisiae host cell, wherein the fragment can be assayed for antigen binding, while the full bivalent antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies from the library that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells used for making the antibody display system are also provided along with methods of use thereof.
    Type: Application
    Filed: November 18, 2021
    Publication date: January 11, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Michelle Castor, Ming-Tang Chen, Chung-Ming Hsieh
  • Publication number: 20230403024
    Abstract: An embodiment of the present disclosure provides a conversion circuit for converting a single-ended input to a differential input, which has fewer switches and fewer capacitors. This conversion circuit increases the signal-to-noise ratio (SNR), and the conversion circuit directly uses the higher supply voltage AVDD without being bucked by the regulator, wherein the common mode voltage is AVDD/2N, and N is greater than 1. Overall, not only the circuit area is smaller and the SNR is higher, but also the manufacturing cost is reduced. In addition, compared with the prior art, the conversion circuit of the embodiment of the present disclosure has only three operation periods, so the control is simpler and the operation speed is faster.
    Type: Application
    Filed: February 10, 2023
    Publication date: December 14, 2023
    Inventors: YEH-TAI HUNG, WEI-CHAN HSU, CHUNG MING HSIEH
  • Patent number: 11824393
    Abstract: A power supply device for providing a driving voltage of an encryption/decryption device. When the encryption/decryption device is in operation and its driving voltage falls within the voltage range formed by an upper limit voltage and a lower limit voltage, only a supply voltage provided by a secure power supply device is used as the driving voltage for the encryption/decryption device. When the encryption and decryption device is in operation and its driving voltage falls outside the voltage range formed by the upper limit voltage and the lower limit voltage, the supply voltage and a stable voltage provided by the stable voltage source are used as the driving voltage at the same time, the supply voltage is further adjusted until the driving voltage falls within the voltage range formed by the upper limit voltage and the lower limit voltage, and then continue to use only the supply voltage as the driving voltage.
    Type: Grant
    Filed: September 26, 2022
    Date of Patent: November 21, 2023
    Assignee: NUVOTON TECHNOLOGY CORPORATION
    Inventors: Po-Hsuan Huang, Chung Ming Hsieh
  • Publication number: 20230272056
    Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Application
    Filed: April 8, 2021
    Publication date: August 31, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Chung-Ming Hsieh, Michelle Castor, Ming-Tang Chen, Alan C. Cheng, Scott A. Hollingsworth, Veronica M. Juan, Madhura Shidhore, Song Yang, Renee C.T. Moore
  • Publication number: 20230265175
    Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.
    Type: Application
    Filed: June 23, 2021
    Publication date: August 24, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Jeanne E. Baker, Sophie Parmentier Batteur, Ming-Tang Chen, Alan C. Cheng, Chung-Ming Hsieh, Carl Mieczkowski, Sokreine Suon
  • Patent number: 11702467
    Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: July 18, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Jeanne E. Baker, Sophie Parmentier Batteur, Ming-Tang Chen, Alan C. Cheng, Chung-Ming Hsieh, Carl Mieczkowski, Sokreine Suon
  • Patent number: 11705918
    Abstract: An incremental analog-to-digital converter including a first-stage non-delay memorization element and other elements is disclosed. An ending time point of a second reset signal received by the first-stage non-delay memorization element is later than an ending time point of a first reset signal received by the other elements by at least one clock cycle, a reset duration of the first-stage non-delay memorization element is longer than a reset duration of the other element, so that the first-stage non-delay memorization element can be prevented from occurring overshoot or spike on an output thereof, and the incremental analog-to-digital converter can maintain a good signal-to-noise and distortion ratio under the condition that the internal elements has low swing limits.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: July 18, 2023
    Assignee: NUVOTON TECHNOLOGY CORPORATION
    Inventor: Chung Ming Hsieh
  • Publication number: 20230167168
    Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.
    Type: Application
    Filed: June 23, 2021
    Publication date: June 1, 2023
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jeanne E. Baker, Sophie Parmentier Batteur, Ming-Tang Chen, Alan C. Cheng, Chung-Ming Hsieh, Carl Mieczkowski, Sokreine Suon
  • Publication number: 20230115035
    Abstract: A power supply device for providing a driving voltage of an encryption/decryption device. When the encryption/decryption device is in operation and its driving voltage falls within the voltage range formed by an upper limit voltage and a lower limit voltage, only a supply voltage provided by a secure power supply device is used as the driving voltage for the encryption/decryption device. When the encryption and decryption device is in operation and its driving voltage falls outside the voltage range formed by the upper limit voltage and the lower limit voltage, the supply voltage and a stable voltage provided by the stable voltage source are used as the driving voltage at the same time, the supply voltage is further adjusted until the driving voltage falls within the voltage range formed by the upper limit voltage and the lower limit voltage, and then continue to use only the supply voltage as the driving voltage.
    Type: Application
    Filed: September 26, 2022
    Publication date: April 13, 2023
    Inventors: PO-HSUAN HUANG, CHUNG MING HSIEH
  • Publication number: 20230112863
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: April 29, 2022
    Publication date: April 13, 2023
    Inventors: Chengbin WU, Dominic J. AMBROSI, Chung-ming HSIEH, Tariq GHAYUR
  • Publication number: 20230102101
    Abstract: Heavy chain antibody variable domain (VHH) display libraries are described comprising human-like VHH comprising three synthetically generated complementarity determining region (CDR) areas in which the amino acids at each of positions 44 and 45 or positions 37, 44, 45, and 47 comprise the amino acid at the corresponding position of a Camelid VHH, wherein the amino acid positions are according to Kabat numbering Human-like VHHs identified using these libraries may be useful for the manufacture of therapeutics for treating diseases and disorders.
    Type: Application
    Filed: March 1, 2021
    Publication date: March 30, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Lei Chen, Ming-Tang Chen, Chung-Ming Hsieh, Alexander Mario Sevy