Abstract: The present disclosure provides a digital low-dropout regulator (DLDO) and an electronic device using the same. The DLDO includes a voltage comparator circuit, a switch control circuit, a power switch module, and an asynchronous clock generation circuit. The voltage comparator circuit compares a reference voltage with the output voltage to output a comparison result signal. The switch control circuit generates a switch control signal based on the comparison result signal. The power switch module is controlled by the switch control signal to switch between the on state and the off state, thereby adjusting the output voltage. The asynchronous clock generation circuit generates a reference clock signal that is asynchronous with the system clock signal used in the load circuit and has a higher clock frequency. This allows the switch control circuit to update the switch control signal based on the reference clock signal.

Abstract: An entropy maintaining method for a true random number generator and a true random number generator thereof are provided. The true random number generator includes a plurality of first ring oscillation output circuits. The entropy maintaining method includes providing at least one second ring oscillation output circuit in the true random number generator, the at least one second ring oscillation output circuit initially disabled; after the true random number generator is operated, recording logic of generated random bit signals every preset time; counting the logic of the random number bit signal to obtain a statistic value; and determining, according to the statistic value, whether the at least one second ring oscillation output circuit is operated in combination with the plurality of first ring oscillation output circuits to generate the random bit signals.

Abstract: A signal conversion device for converting a single-ended input voltage into a differential input voltage having a positive input voltage and a negative input voltage is provided. During a sampling phase, a holding phase, and a common-mode voltage generation phase, a capacitor related to the positive input voltage is electrically connected to the single-ended input voltage, and a capacitor related to the negative input voltage is electrically connected to a preset voltage. During a single-ended to differential phase, the capacitor related to the positive input voltage is electrically connected to the preset voltage, and the capacitor related to the negative input voltage is electrically connected to the single-ended input voltage. Hence, the common-mode voltage is not related to a capacitance ratio, and the capacitors does not need to be designed as switching capacitors with multiple switches. No complex control is required, and the parasitic effect of the circuit can be reduced.

Abstract: A power supply device is used to provide power to an encryption and decryption device of a security system, including a safety power supply device, which is used to supply the supply voltage according to the system voltage; a regulated voltage source, which is used to provide a regulated voltage; and a voltage selection device, which is electrically connected with the safety power supply device, the stable voltage source and the encryption and decryption device. During the startup period of the security system, or, after the startup period of the security system and the encryption/decryption device performs encryption/decryption, only the supply voltage is selected as the driving voltage of the encryption/decryption device. After the startup period of the security system and the encryption and decryption device does not perform encryption and decryption, the voltage only the regulated voltage is selected as the driving voltage of the encryption and decryption device.

Abstract: An embodiment of the present disclosure provides a conversion circuit for converting a single-ended input to a differential input, which has fewer switches and fewer capacitors. This conversion circuit increases the signal-to-noise ratio (SNR), and the conversion circuit directly uses the higher supply voltage AVDD without being bucked by the regulator, wherein the common mode voltage is AVDD/2N, and N is greater than 1. Overall, not only the circuit area is smaller and the SNR is higher, but also the manufacturing cost is reduced. In addition, compared with the prior art, the conversion circuit of the embodiment of the present disclosure has only three operation periods, so the control is simpler and the operation speed is faster.

Abstract: A Saccharomyces cerevisiae antibody display system that simultaneously secrets and displays antibody fragments from a very large size synthetic nave human antibody library for therapeutic antibody lead discovery and engineering is described. A bait anchor complexed with a monovalent antibody fragment is tethered on the surface of the S. cerevisiae host cell, wherein the fragment can be assayed for antigen binding, while the full bivalent antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies from the library that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells used for making the antibody display system are also provided along with methods of use thereof.

Abstract: An embodiment of the present disclosure provides a conversion circuit for converting a single-ended input to a differential input, which has fewer switches and fewer capacitors. This conversion circuit increases the signal-to-noise ratio (SNR), and the conversion circuit directly uses the higher supply voltage AVDD without being bucked by the regulator, wherein the common mode voltage is AVDD/2N, and N is greater than 1. Overall, not only the circuit area is smaller and the SNR is higher, but also the manufacturing cost is reduced. In addition, compared with the prior art, the conversion circuit of the embodiment of the present disclosure has only three operation periods, so the control is simpler and the operation speed is faster.

Abstract: A power supply device for providing a driving voltage of an encryption/decryption device. When the encryption/decryption device is in operation and its driving voltage falls within the voltage range formed by an upper limit voltage and a lower limit voltage, only a supply voltage provided by a secure power supply device is used as the driving voltage for the encryption/decryption device. When the encryption and decryption device is in operation and its driving voltage falls outside the voltage range formed by the upper limit voltage and the lower limit voltage, the supply voltage and a stable voltage provided by the stable voltage source are used as the driving voltage at the same time, the supply voltage is further adjusted until the driving voltage falls within the voltage range formed by the upper limit voltage and the lower limit voltage, and then continue to use only the supply voltage as the driving voltage.

Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: An incremental analog-to-digital converter including a first-stage non-delay memorization element and other elements is disclosed. An ending time point of a second reset signal received by the first-stage non-delay memorization element is later than an ending time point of a first reset signal received by the other elements by at least one clock cycle, a reset duration of the first-stage non-delay memorization element is longer than a reset duration of the other element, so that the first-stage non-delay memorization element can be prevented from occurring overshoot or spike on an output thereof, and the incremental analog-to-digital converter can maintain a good signal-to-noise and distortion ratio under the condition that the internal elements has low swing limits.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: A power supply device for providing a driving voltage of an encryption/decryption device. When the encryption/decryption device is in operation and its driving voltage falls within the voltage range formed by an upper limit voltage and a lower limit voltage, only a supply voltage provided by a secure power supply device is used as the driving voltage for the encryption/decryption device. When the encryption and decryption device is in operation and its driving voltage falls outside the voltage range formed by the upper limit voltage and the lower limit voltage, the supply voltage and a stable voltage provided by the stable voltage source are used as the driving voltage at the same time, the supply voltage is further adjusted until the driving voltage falls within the voltage range formed by the upper limit voltage and the lower limit voltage, and then continue to use only the supply voltage as the driving voltage.

Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.

Abstract: A power supply device is provided with a secure power supply device, a voltage detection circuit, a stable voltage source and a switch. By using the voltage detection circuit, whether a driving voltage of an encryption/decryption device is insufficient to control the on and off the switch, so as to determine whether only the secure power supply device provides a supply voltage to the encryption/decryption device as the driving voltage. Alternatively, the supply voltage of the secure power supply device and a stable voltage of the stable voltage source are provided simultaneously to the encryption/decryption device as the driving voltage. In other words, once the driving voltage drops (that is, the encryption/decryption device consumes a large current for encryption/decryption), the stable voltage source immediately provides the stable voltage to the encryption/decryption device as part of the driving voltage to ensure that the encryption/decryption device can normally work.

Abstract: Heavy chain antibody variable domain (VHH) display libraries are described comprising human-like VHH comprising three synthetically generated complementarity determining region (CDR) areas in which the amino acids at each of positions 44 and 45 or positions 37, 44, 45, and 47 comprise the amino acid at the corresponding position of a Camelid VHH, wherein the amino acid positions are according to Kabat numbering Human-like VHHs identified using these libraries may be useful for the manufacture of therapeutics for treating diseases and disorders.

Abstract: A power supply device is used to provide power to an encryption and decryption device of a security system, including a safety power supply device, which is used to supply the supply voltage according to the system voltage; a regulated voltage source, which is used to provide a regulated voltage; and a voltage selection device, which is electrically connected with the safety power supply device, the stable voltage source and the encryption and decryption device. During the startup period of the security system, or, after the startup period of the security system and the encryption/decryption device performs encryption/decryption, only the supply voltage is selected as the driving voltage of the encryption/decryption device. After the startup period of the security system and the encryption and decryption device does not perform encryption and decryption, the voltage only the regulated voltage is selected as the driving voltage of the encryption and decryption device.

Abstract: A voltage regulation system is provided. In the voltage regulation system, a frequency of a clock signal is adjusted and a pulse generator is controlled to output a pulse signal to a switch power stage circuit, to enable the switch power stage circuit to adjust an output voltage and output the adjusted output voltage to the load element. Through the aforementioned configuration, the switch power stage circuit adjusts the output voltage according to the situation of the load element, thus decreasing the power loss of the switch power stage circuit.

Abstract: An incremental analog-to-digital converter including a first-stage non-delay memorization element and other elements is disclosed. An ending time point of a second reset signal received by the first-stage non-delay memorization element is later than an ending time point of a first reset signal received by the other elements by at least one clock cycle, a reset duration of the first-stage non-delay memorization element is longer than a reset duration of the other element, so that the first-stage non-delay memorization element can be prevented from occurring overshoot or spike on an output thereof, and the incremental analog-to-digital converter can maintain a good signal-to-noise and distortion ratio under the condition that the internal elements has low swing limits.