Abstract: A protection circuit is adapted to a switching-capacitor regulation circuit having a capacitor. The protection circuit comprises a current source, first and second switch circuits, and a control unit. First, the control unit turns on the second switch circuit to make a top end and a bottom end of the capacitor, and control the first switch circuit to make the current source no connect the capacitor, and then set a voltage of the top and the bottom to be a first preset voltage. Next, the control unit turns off the second switch circuit to disconnect the top end and the bottom end, and turn on the first switch circuit to flow current from the bottom end of the capacitor. When a voltage difference between the top end and the bottom end is equal to a preset initial voltage, the control unit control the first switch circuit to disconnect the current source and the capacitor; next, the control unit controls current flow in or out from the top of the capacitor based on the voltage on the top of the capacitor.

Abstract: A zero current detection system for a switching regulator is provided. The switching includes an inductor. In the zero current detection system, a comparator has a positive input coupled to a terminal of the inductor and an output terminal for outputting a comparison result signal; a first signal latch circuit has a clock terminal for receiving the comparison result signal and outputting a latched output signal; a delay line module starts counting upon receipt of the latched output signal, and then outputs a zero current detection signal after counting a delay time; in response to the zero current detection signal, a voltage sampling module samples a node voltage at two different time points, to generate two sampling voltages; a delay control module adjusts the delay time of the delay line module according to the two sampling voltages.

Abstract: A dynamic comparator includes a differential amplifier stage, a switching unit and a switching charge storage unit. The switching charge storage unit includes a plurality of switching transistors, and a charge storage capacitor electrically connected to the plurality of switching transistors. When an operational mode of the dynamic comparator is switched from a comparison state to a reset state, a voltage on one of a first terminal and a second terminal of the charge storage capacitor is increased from a half of the system voltage to a system voltage, so as to implement a charge recycle effect. The dynamic comparator of the present invention can have lower power consumption and lower charge-discharge current.

Abstract: The present invention encompasses antagonist anti-CD40 antibodies and antigen-binding portions thereof. Specifically, the invention relates to humanized anti-CD40 antibodies. In certain embodiments, antibodies of the invention neutralize human CD40 (hCD40) activity. Antibodies, or antibody portions, of the invention are useful for detecting CD40 and for inhibiting CD40 activity, e.g., in a human subject suffering from a disorder in which CD40 activity is detrimental.

Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Abstract: A digital regulator system is provided. The digital regulator system includes a digital regulator circuit and a compensation circuit. The digital regulator circuit outputs an output current and an output voltage. The digital regulator circuit adjust the output current by decreasing or increasing a unit current according to at least a reference voltage and a feedback voltage. The compensation circuit receives the output voltage as well as decreases or increases a unit voltage of the output voltage to generate and output the feedback voltage according to the variation of the output current.

Abstract: A protection circuit is adapted to a switching-capacitor regulation circuit having a capacitor. The protection circuit comprises a current source, first and second switch circuits, and a control unit. First, the control unit turns on the second switch circuit to make a top end and a bottom end of the capacitor, and control the first switch circuit to make the current source no connect the capacitor, and then set a voltage of the top and the bottom to be a first preset voltage. Next, the control unit turns off the second switch circuit to disconnect the top end and the bottom end, and turn on the first switch circuit to flow current from the bottom end of the capacitor. When a voltage difference between the top end and the bottom end is equal to a preset initial voltage, the control unit control the first switch circuit to disconnect the current source and the capacitor; next, the control unit controls current flow in or out from the top of the capacitor based on the voltage on the top of the capacitor.

Abstract: A voltage regulation system utilizes a controller to select one of a continuous comparator and a discrete comparator to operate, making one of the continuous comparator and the discrete comparator output a pulse signal to the controller. The controller controls a switched power stage circuit to supply power to a load element. Through the aforementioned configuration, the switched power stage circuit adjusts the power supply based on the condition of the load element, thus decreasing the power loss of the switched power stage circuit.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: A voltage regulation system utilizes a controller to select one of a continuous comparator and a discrete comparator to operate, making one of the continuous comparator and the discrete comparator output a pulse signal to the controller. The controller controls a switched power stage circuit to supply power to a load element. Through the aforementioned configuration, the switched power stage circuit adjusts the power supply based on the condition of the load element, thus decreasing the power loss of the switched power stage circuit.

Abstract: A voltage regulation system is provided. In the voltage regulation system, a frequency of a clock signal is adjusted and a pulse generator is controlled to output a pulse signal to a switch power stage circuit, to enable the switch power stage circuit to adjust an output voltage and output the adjusted output voltage to the load element. Through the aforementioned configuration, the switch power stage circuit adjusts the output voltage according to the situation of the load element, thus decreasing the power loss of the switch power stage circuit.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: A startup circuit initializes a voltage of a capacitor of a switch-capacitor regulator. The startup circuit includes a voltage forming circuit and a control unit. The voltage forming circuit selectively electrically connected to the top and the bottom of the capacitor. In a first operation phase, the voltage forming circuit is electrically connected to the top and bottom of the capacitor, and the top and bottom of the capacitor are connected to each other, and the voltages of the top and bottom are set as a preset high voltage. In a second operation phase, the voltage forming circuit disconnects the top and the bottom, and generates current flowing out from the bottom of the capacitor until the voltage cross the capacitor is equal to the preset initial voltage. In the third operation phase, the startup circuit is disconnected from the capacitor.

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

Abstract: A power converter includes a switched-capacitor conversion circuit and an inductor buck circuit. The switched-capacitor conversion circuit receives an input voltage, and is operated, according to the first switching frequency, to convert the input voltage into an intermediate voltage. The inductor buck circuit and the switched-capacitor conversion circuit are connected in series. The inductor buck circuit receives the intermediate voltage, and generates an output voltage on a conversion output terminal thereof according to the intermediate voltage. The minimum value of the first switching frequency is determined by the intermediate voltage.

Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).

Abstract: A startup circuit initializes a voltage of a capacitor of a switch-capacitor regulator. The startup circuit includes a voltage forming circuit and a control unit. The voltage forming circuit selectively electrically connected to the top and the bottom of the capacitor. In a first operation phase, the voltage forming circuit is electrically connected to the top and bottom of the capacitor, and the top and bottom of the capacitor are connected to each other, and the voltages of the top and bottom are set as a preset high voltage. In a second operation phase, the voltage forming circuit disconnects the top and the bottom, and generates current flowing out from the bottom of the capacitor until the voltage cross the capacitor is equal to the preset initial voltage. In the third operation phase, the startup circuit is disconnected from the capacitor.

Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.

Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Abstract: A digital regulator system is provided. The digital regulator system includes a digital regulator circuit and a compensation circuit. The digital regulator circuit outputs an output current and an output voltage. The digital regulator circuit adjust the output current by decreasing or increasing a unit current according to at least a reference voltage and a feedback voltage. The compensation circuit receives the output voltage as well as decreases or increases a unit voltage of the output voltage to generate and output the feedback voltage according to the variation of the output current.