Patents by Inventor Chuo Chen

Chuo Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CGAS antagonist compounds
    Patent number: 12655118
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: June 28, 2024
    Date of Patent: June 16, 2026
    Assignees: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
  • QUINOLINE cGAS ANTAGONIST COMPOUNDS
    Publication number: 20260042737
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: February 27, 2025
    Publication date: February 12, 2026
    Inventors: Qi Wei, Heping Shi, Matt Tschantz, Jian Qiu, Youtong Wu, Huiling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
  • ALLOSTERIC STING MODULATORS AND METHODS OF USE
    Publication number: 20250170120
    Abstract: Provided are various Stimulator of Interferon Genes (STING) allosteric modulators as well as methods of making and use thereof. Specifically provided herein are highly active STING inhibitors (antagonists) and activators (agonists). The compounds provide herein may be prepared as pharmaceutical compositions and used in methods of treating conditions related to disrupted or defective STING signaling.
    Type: Application
    Filed: January 31, 2023
    Publication date: May 29, 2025
    Inventors: Yong LU, Liping LI, Jie LI, Xuewu ZHANG, Xiaochen BAI, Chuo CHEN
  • Antibody-sting agonist conjugates and their use in immunotherapy
    Patent number: 12311030
    Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: May 27, 2025
    Assignees: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Zhijian Chen, Heping Shi, Qi Wei, Chuo Chen, Lijun Sun, Jian Qiu, Youtong Wu
  • Quinoline cGAS antagonist compounds
    Patent number: 12281078
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: April 22, 2025
    Assignees: Immunesensor Therapeutics, Inc., The Board of Regents of The University of Texas System
    Inventors: Qi Wei, Heping Shi, Matt Tschantz, Jian Qiu, Youtong Wu, Huiling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
  • cGAS ANTAGONIST COMPOUNDS
    Publication number: 20250115564
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: June 28, 2024
    Publication date: April 10, 2025
    Inventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
  • QUINOLINE cGAS ANTAGONIST COMPOUNDS
    Publication number: 20250115579
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: September 10, 2024
    Publication date: April 10, 2025
    Inventors: Jian Qiu, Qi Wei, Matt Tschantz, Heping Shi, Youtong Wu, Huiling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
  • Quinoline cGAS antagonist compounds
    Patent number: 12134609
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: June 13, 2023
    Date of Patent: November 5, 2024
    Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jian Qiu, Qi Wei, Matt Tschantz, Heping Shi, Youtong Wu, Huiling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
  • Quinoline cGAS antagonist compounds
    Patent number: 12091387
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: July 17, 2023
    Date of Patent: September 17, 2024
    Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Qi Wei, Heping Shi, Matt Tschantz, Jian Qiu, Youtong Wu, Huiling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
  • cGAS antagonist compounds
    Patent number: 12065416
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: January 23, 2023
    Date of Patent: August 20, 2024
    Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
  • QUINOLINE cGAS ANTAGONIST COMPOUNDS
    Publication number: 20240092760
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: June 13, 2023
    Publication date: March 21, 2024
    Inventors: Jian QIU, Qi WEI, Matt TSCHANTZ, Heping SHI, Youtong WU, Huiling TAN, Lijun SUN, Chuo CHEN, Zhijian CHEN
  • cGAS ANTAGONIST COMPOUNDS
    Publication number: 20240043393
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: January 23, 2023
    Publication date: February 8, 2024
    Inventors: Boyu ZHONG, Lijun SUN, Heping SHI, Jing LI, Chuo CHEN, Zhijian CHEN
  • Quinoline cGAS antagonist compounds
    Patent number: 11873291
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: January 16, 2024
    Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jian Qiu, Qi Wei, Matt Tschantz, Heping Shi, Youtong Wu, Hulling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
  • QUINOLINE cGAS ANTAGONIST COMPOUNDS
    Publication number: 20240002346
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: March 2, 2023
    Publication date: January 4, 2024
    Inventors: Qi WEI, Heping SHI, Matt TSCHANTZ, Jian QIU, Youtong WU, Huiling TAN, Lijun SUN, Chuo CHEN, Zhijian CHEN
  • QUINOLINE cGAS ANTAGONIST COMPOUNDS
    Publication number: 20230357158
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: July 17, 2023
    Publication date: November 9, 2023
    Inventors: Qi WEI, Heping SHI, Matt TSCHANTZ, Jian QIU, Youtong WU, Huiling TAN, Lijun SUN, Chuo CHEN, Zhijian CHEN
  • QUINOLINE cGAS ANTAGONIST COMPOUNDS
    Publication number: 20230081291
    Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: September 3, 2021
    Publication date: March 16, 2023
    Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Jian QIU, Qi WEI, Matt TSCHANTZ, Heping SHI, Youtong WU, Huiling TAN, Lijun SUN, Chuo CHEN, Zhijian CHEN
  • CGAS antagonist compounds
    Patent number: 11597707
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: March 7, 2023
    Assignees: IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
  • cGAS ANTAGONIST COMPOUNDS
    Publication number: 20220356158
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: March 3, 2021
    Publication date: November 10, 2022
    Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Boyu ZHONG, Lijun SUN, Heping SHI, Jing LI, Chuo CHEN, Zhijian CHEN
  • Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway
    Patent number: 11492368
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: November 8, 2022
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Zhijian Chen, Lijun Sun, Jiaxi Wu, Heping Shi, Chuo Chen
  • CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20220340613
    Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
    Type: Application
    Filed: March 17, 2022
    Publication date: October 27, 2022
    Inventors: Boyu ZHONG, Heping SHI, Yuanwei DAI, Qi WEI, Chuo CHEN, Zhijian CHEN, Lijun SUN