Patents by Inventor Chuo Chen

Chuo Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170304240
    Abstract: The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.
    Type: Application
    Filed: May 12, 2015
    Publication date: October 26, 2017
    Inventors: Chengcheng ZHANG, Yi LIU, Junke ZHENG, Mi DENG, Chuo CHEN, Jiawei LIU
  • Publication number: 20170296655
    Abstract: Cyclic-GMP-AMP (cGAMP), including 2?,3?-cGAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.
    Type: Application
    Filed: January 29, 2017
    Publication date: October 19, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Patent number: 9783550
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: October 10, 2017
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Lawrence Lum, Chuo Chen
  • Publication number: 20160115177
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Application
    Filed: May 14, 2014
    Publication date: April 28, 2016
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Lawrence LUM, Chuo CHEN
  • Publication number: 20150374696
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Application
    Filed: June 2, 2015
    Publication date: December 31, 2015
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Lawrence LUM, Michael G. ROTH, Baozhi CHEN, Chuo CHEN, Michael E. DODGE, Wei TANG
  • Publication number: 20150343056
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.
    Type: Application
    Filed: December 16, 2013
    Publication date: December 3, 2015
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Publication number: 20150157633
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Application
    Filed: May 6, 2013
    Publication date: June 11, 2015
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Lawrence Lum, Michael Roth, Baozhi Chen, Michael Dodge, Chuo Chen
  • Patent number: 9045416
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: June 2, 2015
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Lawrence Lum, Michael G. Roth, Baozhi Chen, Chuo Chen, Michael E. Dodge, Wei Tang
  • Publication number: 20140038922
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Application
    Filed: May 1, 2013
    Publication date: February 6, 2014
    Inventors: Lawrence LUM, Michael G. ROTH, Baozhi CHEN, Chuo CHEN, Michael E. DODGE, Wei TANG
  • Patent number: 8445491
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: May 21, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Lawrence Lum, Michael G. Roth, Baozhi Chen, Chuo Chen, Michael E. Dodge, Wei Tang
  • Publication number: 20110136813
    Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
    Type: Application
    Filed: May 27, 2009
    Publication date: June 9, 2011
    Inventors: Lawrence Lum, Michael G. Roth, Baozhi Chen, Chuo Chen, Michael E. Dodge, Wei Tang
  • Publication number: 20070264623
    Abstract: The present invention generally relates to nanoscale wires for use in determining analytes suspected to be present in a sample, especially in connection with determining information about a sample containing, or suspected of containing, two or more analytes. For example, the invention can involve a competitive, uncompetitive, or non-competitive binding assay including a nanoscale wire to a sample containing a species able to interact with the retain entity to produce a product, where the sample also contains or is suspected of containing a second species able to interact with the reaction entity to prevent production of the product resulting from interaction of the first species and the reaction entity. Based upon determination of production of the product, determination of the second species in the sample can be made.
    Type: Application
    Filed: June 15, 2005
    Publication date: November 15, 2007
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Wayne Wang, Chuo Chen, Keng-Hui Lin, Ying Fang, Charles Lieber
  • Publication number: 20010024798
    Abstract: The present invention provides biomimetic compounds and libraries thereof, as well as methods for their production. In general, the inventive method involves the selection of a desired biological synthetic pathway and mimics that synthetic pathway utilizing modern synthetic tools. The structures formed from this method are preferably generated in fewer than four steps. These scaffold structures can then be functionalized to yield biomimetic compounds and libraries of compounds. In preferred embodiments, biomimetic compounds and libraries are generated from an oxidative phenolic coupling reaction. In other particularly preferred embodiments, the compounds and libraries of compounds are generated from cascade reactions to yield bicyclo [n.3.1] ring systems, medium ring systems, and fused ring systems.
    Type: Application
    Filed: April 19, 2001
    Publication date: September 27, 2001
    Inventors: Matthew D. Shair, Craig W. Lindsley, Henry E. Pelish, Scott M. Sheehan, Brian C. Goess, Mark E. Layton, Lawrence K. Chan, Chuo Chen, Nicholas J. Westwood
  • Patent number: 5436363
    Abstract: A depolymerization and purification process, by which a poly(alkyl-.alpha.-cyanoacrylate) feed is depolymerized into high-purity cyanoacrylate monomers without the use of a high-boiling heat transfer medium such as tricresyl phosphate. The poly(alkyl-.alpha.-cyanoacrylate) feed, which contains one or more polymerization inhibitors such as hydroquinone and phosphorus pentoxide, is first introduced into a thin-film evaporator for a depolymerization reaction. The temperature of the film evaporator is maintained at about 200.degree..about.260.degree. C., and operated under a vacuum of 1.about.20 mm Hg. The produced gas stream from the depolymerization reactor is subject to a two-stage heat transfer process for condensation and purification. The first stage involves a very-high temperature condenser (about 150.degree. C.). The residue collected in the first stage condenser contains primarily dimers of .alpha.-cyanoacrylate.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: July 25, 1995
    Assignee: Industrial Technology Research Institute
    Inventors: Tien-Lu Wang, Tso-Chi Chiu, Kun-Chuo Chen