Patents by Inventor Clark A. Sehon

Clark A. Sehon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STEREOSELECTIVE HYDROGENATION OF A KETONE
    Publication number: 20110306765
    Abstract: The present invention relates to a method comprising reducing a ketone of formula I: with an enantioselective hydrogenating agent to form substantially enantiomerically pure alcohol of formula II: where R—R4 and m are as defined herein. The method of the present invention is useful for making CCR2 modulators as wells as precursors CCR2 modulators.
    Type: Application
    Filed: February 23, 2010
    Publication date: December 15, 2011
    Inventors: Pamela A. Haile, Clark A. Sehon, Huan Wang
  • SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS
    Publication number: 20110124671
    Abstract: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof; where R1-R5, Y, m, n, and p are defined herein. Compounds and compositions of the present invention are useful the treatment of atherosclerosis.
    Type: Application
    Filed: August 14, 2008
    Publication date: May 26, 2011
    Inventors: Brian W. Budzik, Michael Jonathan Bury, Minghua Gu, Ronggang Liu, Feng Ren, Clark A. Sehon, Gren Z. Wang, Jing Zhang
  • SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS
    Publication number: 20110034499
    Abstract: The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
    Type: Application
    Filed: June 20, 2008
    Publication date: February 10, 2011
    Inventors: Brian W. Budzik, Hilary Schenck Eidam, Ryan Michael Fox, Krista B. Goodman, Dimitar B. Gotchev, Pamela A. Haile, Terry Vincent Hughes, Ronggang Liu, Nathan A. Miller, Tamara Ann Miskowski, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang, Jing Zhang
  • MORPHOLINYL AND PYRROLIDINYL ANALOGS
    Publication number: 20100256130
    Abstract: The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: May 19, 2010
    Publication date: October 7, 2010
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • Morpholinyl and pyrrolidinyl analogs
    Patent number: 7749998
    Abstract: The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: July 6, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • Spiroindolines as modulators of chemokine receptors
    Patent number: 7723350
    Abstract: The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: May 25, 2010
    Assignee: Glaxo Group Limited
    Inventors: Hilary Schenck Eidam, Pamela A. Haile, Terry Vincent Hughes, Clark A. Sehon
  • MORPHOLINYL AND PYRROLIDINYL ANALOGS
    Publication number: 20090275571
    Abstract: The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: July 20, 2007
    Publication date: November 5, 2009
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS
    Publication number: 20080318990
    Abstract: The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
    Type: Application
    Filed: June 20, 2008
    Publication date: December 25, 2008
    Inventors: Hilary Schenck Eidam, Pamela A. Haile, Terry Vincent Hughes, Clark A. Sehon
  • CCK-1 receptor modulators
    Patent number: 7465808
    Abstract: There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: December 16, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Terrance D. Barrett, J. Guy Breitenbucher, Laurent Gomez, Michael D. Hack, Liming Huang, Kelly J. McClure, Magda F. Morton, Clark A. Sehon, Nigel P. Shankley
  • Pyridinyl Sulfonamide Modulators of Chemokine Receptors
    Publication number: 20080293720
    Abstract: The present invention relates to compounds of following formula: or pharmaceutically acceptable salts thereof; pharmaceutical compositions containing them, and their use in the treatment of disorders mediated by the CCR-2 receptor.
    Type: Application
    Filed: December 4, 2006
    Publication date: November 27, 2008
    Applicant: Glaxo Group Limited
    Inventors: Pamela A. Cleary, Krista B. Goodman, Simon Peace, Joanne Philp, Clark A. Sehon
  • Chemical Compounds
    Publication number: 20080293716
    Abstract: There is provided a compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof:
    Type: Application
    Filed: January 28, 2005
    Publication date: November 27, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: David Harold Drewry, Robert Neil Hunter, III, David Kendall Jung, James Andrew Linn, Clark Sehon, Robert A. Stavenger
  • CCK-1 receptor modulators
    Patent number: 7456208
    Abstract: Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: November 25, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: J. Guy Breitenbucher, Michael D. Hack, Clark A. Sehon
  • Chemical Compounds
    Publication number: 20080275062
    Abstract: There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy, C1-4alkoxycarbonyl, C1-4alkylsulfonyl and a group R3R4NSO2 (wherein R3 and R4 are independently hydrogen or C1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consistin
    Type: Application
    Filed: January 28, 2005
    Publication date: November 6, 2008
    Inventors: David Harold Drewry, David Kendall Jung, James Andrew Linn, Robert Neil Hunter, Dennis Lee, Robert A. Stavenger, Clark Sehon
  • Morpholinyl and pyrrolidinyl analogs
    Patent number: 7432258
    Abstract: The present invention relates to 4?-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin- 4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid and its pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: October 7, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • Novel Inhibitors of Rho-Kinases
    Publication number: 20080125427
    Abstract: Novel inhibitors of Rho-kinases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: May 29, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Clark A. Sehon, Dennis Lee, Krista B. Goodman, Gren Z. Wang, Andrew Q. Viet
  • MORPHOLINYL AND PYRROLIDINYL ANALOGS
    Publication number: 20080021023
    Abstract: The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
    Type: Application
    Filed: July 20, 2007
    Publication date: January 24, 2008
    Inventors: Krista B. Goodman, Michael J. Neeb, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang
  • CCK-1 Receptor Modulators
    Publication number: 20070249698
    Abstract: Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.
    Type: Application
    Filed: July 3, 2007
    Publication date: October 25, 2007
    Inventors: J. Breitenbucher, Michael Hack, Clark Sehon
  • CCK-1 receptor modulators
    Patent number: 7250434
    Abstract: Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: July 31, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: J. Guy Breitenbucher, Michael D. Hack, Clark A. Sehon
  • Substituted pyrazoles and methods of treatment with substituted pyrazoles
    Publication number: 20070117785
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases or allergic conditions, including atopic allergic conditions, mediated by cathepsin S are described.
    Type: Application
    Filed: October 4, 2006
    Publication date: May 24, 2007
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Joanne Quan, Clark Sehon, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei, Ann Welton
  • CCK-1 receptor modulators
    Patent number: 7037931
    Abstract: There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: May 2, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Terrance D. Barrett, J. Guy Breitenbucher, Laurent Gomez, Michael D. Hack, Liming Huang, Kelly J. McClure, Magda F. Morton, Clark A. Sehon, Nigel P. Shankley