Abstract: A syringe assembly having needle isolation features includes an elongate barrel having an open proximal end, a chamber for retaining fluid and a tip portion extending from a distal end of the barrel having a passageway therethrough include communication with the chamber. A valve housing extends outwardly from the tip portion of the barrel having a conduit therethrough in communication with the passageway. A needle cannula having a proximal end, a distal end and a lumen therethrough is provided. The proximal end of the needle is connected to the housing so that the lumen is in fluid communication with the conduit. The housing includes internal valve for allowing liquid under pressure in the chamber to flow distally through the conduit and the lumen while preventing unpressurized liquid in the chamber from flowing through the aperture. The internal valve includes a one-way valve structure for preventing liquid flow through the conduit in a proximal direction toward the chamber.

Abstract: A lockable safety shield for a prefillable syringe is provided. The design of the lockable safety shield enhances pharmaceutical manufacturers' ease of assembling the various components as part of its filling or processing of the prefillable syringes in normal practice. A collar is attachable to the distal hub of the prefillable syringe. A safety shield is axially slidable over the collar between a retracted position, wherein the distal end of the piercing element associated with the prefillable syringe is exposed, and an extended position, wherein the safety shield is locked to the collar to protectively cover the distal end of the piercing element. The safety shield includes locking structure configured so that the shield, as supplied to the pharmaceutical manufacturer, can be easily fitted to the syringe. The locking structure includes at least one deflectable arm provided on the body of the shield. The deflectable arm includes a proximal end deflectable towards the interior of the shield.

Abstract: A tip cap is provided for positive sealing engagement with the tip of a syringe barrel. The tip cap includes an inner cap formed from an elastomeric material dimensioned for sealing engagement with the tip of the syringe barrel. The tip cap further includes an outer cap engaged with the inner cap to limit or prevent both axial movement and rotational movement therebetween. The outer cap includes an array of threads for threaded engagement with a luer collar. The luer collar may be a separate component mountable to a syringe barrel or an integral part of the syringe barrel.

Abstract: A syringe nasal sprayer includes an elongate barrel having an open proximal end, a chamber for retaining fluid and a tip portion extending from a distal end of the barrel having a passageway therethrough communicating with the chamber. A stopper is slidably positioned in fluid-tight engagement inside the barrel. An elongate plunger rod projects proximally from the stopper and extends outwardly from the open proximal end of the barrel. A spray nozzle extends outwardly from the tip portion and includes a conduit therethrough in fluid communication with the passageway. A distal end of the nozzle includes a spray aperture in fluid communication with the conduit. The nozzle also includes an internal valve for allowing liquid under pressure in the chamber to flow distally through the conduit and through the aperture while preventing unpressurized liquid in the chamber from flowing through the aperture.

Abstract: A syringe assembly comprising a barrel having a hollow cylindrical shaped body. The body has a proximal first portion with an adjacent second portion which includes a circumferential groove for mounting a finger flange. The barrel has a third portion adjacent to the second portion. The body has a distal tip with a passage therethrough for mounting a needle in fluid communication with the bore. The finger flange has an opening with a diameter defined by a plurality of inwardly facing cantilevers. The diameter of the flange opening is less than that of the body first portion and third portion, requiring a deflection of the cantilevers when the flange is moved over the first portion to the second portion by an installation force. The flange is retained by the barrel through interaction between the inwardly facing cantilevers and the circumferential groove.

Abstract: A syringe assembly includes a hollow cylindrically shaped barrel. The external side of the barrel has a first portion at its proximal end, a second portion adjacent the first portion and a third portion adjacent the second portion. The diameter of the second portion is less than the diameter of the first portion resulting in formation of a shoulder at the intersection of the first and second portions. The third portion outside diameter adjacent the second portion is substantially equal to the outside diameter of the second portion and increases to the outside diameter of the barrel. The assembly further includes a finger flange with a first side and a second side and an opening with an inside wall. The flange opening has an annulus positioned within it which has an opening. The annulus has an end attached to the inside wall of the flange opening and an unattached end projecting toward the first side of the flange, and forms an acute angle with the inside wall of the flange opening.

Abstract: A syringe assembly includes a barrel having an open proximal end, a chamber for retaining fluid and a tip portion extending from a distal end of the barrel having a passageway therethrough communicating with the chamber. A needle cannula having a distal end extends outwardly from the tip portion and includes a lumen in fluid communication with the passageway. A needle shield assembly includes a resilient needle sheath having an open proximal end, a closed distal end, a sidewall defining a receptacle therein and an annular flange extending radially outwardly from the proximal end of the needle sheath. The needle sheath is positioned within an elongate rigid shield having an open proximal end, a distal end and a sidewall therebetween. Structure for holding the sheath within the shield includes a flange-receiving aperture in the needle shield sidewall adjacent to the open proximal end.

Abstract: A syringe barrel includes an elongate barrel portion having a chamber for retaining fluid and a tip extending from a distal end of the barrel portion having a passageway therethrough communicating with the chamber. A coating on the tip increases the roughness of the tip so that the force required to remove a fluid transfer apparatus, removably connected to the tip by a frictional interference fit, is greater than the force required to remove the fluid transfer apparatus from an identically sized tip without the coating.

Abstract: A non-reusable prefilled syringe for a single administration of a drug solution. The syringe has a plunger for expelling the solution which is detachably fitted with an elastomeric cap. The syringe allows for a pre-vein test but is not adapted for reuse. A method of use for subcutaneous injection of mini-doses of the drug solution.