Patents by Inventor Claudio Cobelli

Claudio Cobelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210145371
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Application
    Filed: January 25, 2021
    Publication date: May 20, 2021
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Patent number: 11006903
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: May 18, 2021
    Assignee: DexCom, Inc.
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Publication number: 20210113122
    Abstract: A method, system, and device for improving the accuracy of a continuous glucose monitoring sensor by estimating a CGM signal at a time t+PH using a value of CGM at time t, using a real-time short-time glucose prediction horizon to estimate the real time denoised CGM value with a noise estimation algorithm.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 22, 2021
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Andrea Facchinetti, Giovanni Sparacino, Claudio Cobelli, Boris Kovatchev
  • Patent number: 10881334
    Abstract: A method, system, and device for improving the accuracy of a continuous glucose monitoring sensor by estimating a CGM signal at a time t+PH using a value of CGM at time t, using a real-time short-time glucose prediction horizon to estimate the real time denoised CGM value with a noise estimation algorithm.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: January 5, 2021
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Andrea Facchinetti, Giovanni Sparacino, Claudio Cobelli, Boris Kovatchev
  • Publication number: 20200305804
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Application
    Filed: May 27, 2020
    Publication date: October 1, 2020
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Publication number: 20200281541
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Application
    Filed: May 27, 2020
    Publication date: September 10, 2020
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Publication number: 20200275881
    Abstract: Method for detecting biomechanical and functional parameters of the knee in a situation of performance stress, which comprises: a step for the set up of video recording means (1); a step for the set up of multiple optical markers (4) at specific landmark anatomic points (PA) of the foot and of the knee of a person; a step for the set up, at the plantar surface of the foot, of baropodometric means (5); a step for the acquisition, by means of the video recording means (1), of images of at least one reference action, and a step for the detection, by means of the baropodometric means (5), of baropodometric parameters; a step for calculating, from the baropodometric parameters, the coordinates of the center of pressure (COP) of the foot and of the constraining reaction force (FV) acting on the foot; a step for calculating a force arm (BF) given by the distance between the center of pressure (COP) and a reference point (PR) of the knee; a step for calculating a biomechanical parameter indicative of the valgus momen
    Type: Application
    Filed: April 26, 2018
    Publication date: September 3, 2020
    Inventors: Zimi SAWACHA, Davide PAVAN, Federica CIBIN, Giorgio SBROCCO, Annamaria GUIOTTO, Claudio COBELLI, Fabiola SPOLAOR
  • Patent number: 10702215
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: July 7, 2020
    Assignee: DexCom, Inc.
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Publication number: 20200138385
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Application
    Filed: December 26, 2019
    Publication date: May 7, 2020
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Publication number: 20200060630
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Application
    Filed: November 5, 2019
    Publication date: February 27, 2020
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Patent number: 10555705
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: February 11, 2020
    Assignee: DexCom, Inc.
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Patent number: 10546659
    Abstract: A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: January 28, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Marc D. Breton, Claudio Cobelli, Chiara Dalla Man
  • Publication number: 20190274636
    Abstract: A device for generating alerts for Hypo and Hyperglycemia Prevention from Continuous Glucose Monitoring (CGM) determines a dynamic risk based on both information of glucose level and a trend obtainable from a CGM signals. The device includes a display whose color depends on the DR (for example, red for high DR, green for low risk). When DR exceeds a certain threshold, alerts are generated to suggest the patient to pay attention to the current glucose reading and to its trend, both of which are shown on the display in numbers and symbols (e.g. an arrow with different slope or color).
    Type: Application
    Filed: May 30, 2019
    Publication date: September 12, 2019
    Inventors: Giovanni Sparacino, Claudio Cobelli, Stefania Guerra, Andrea Facchinetti, Michele Schiavon
  • Publication number: 20190223807
    Abstract: Continuous Glucose Monitoring (CGM) devices provide glucose concentration measurements in the subcutaneous tissue with limited accuracy and precision. Therefore, CGM readings cannot be incorporated in a straightforward manner in outcome metrics of clinical trials e.g. aimed to assess new glycaemic-regulation therapies. To define those outcome metrics, frequent Blood Glucose (BG) reference measurements are still needed, with consequent relevant difficulties in outpatient settings. Here we propose a “retrofitting” algorithm that produces a quasi continuous time BG profile by simultaneously exploiting the high accuracy of available BG references (possibly very sparsely collected) and the high temporal resolution of CGM data (usually noisy and affected by significant bias).
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Inventors: Claudio Cobelli, Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino
  • Patent number: 10357207
    Abstract: A device for generating alerts for Hypo and Hyperglycemia Prevention from Continuous Glucose Monitoring (CGM) determines a dynamic risk based on both information of glucose level and a trend obtainable from a CGM signals. The device includes a display whose color depends on the DR (for example, red for high DR, green for low risk). When DR exceeds a certain threshold, alerts are generated to suggest the patient to pay attention to the current glucose reading and to its trend, both of which are shown on the display in numbers and symbols (e.g. an arrow with different slope or color).
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: July 23, 2019
    Assignee: DexCom, Inc.
    Inventors: Giovanni Sparacino, Claudio Cobelli, Stefania Guerra, Andrea Facchinetti, Michele Schiavon
  • Patent number: 10299733
    Abstract: Continuous Glucose Monitoring (CGM) devices provide glucose concentration measurements in the subcutaneous tissue with limited accuracy and precision. Therefore, CGM readings cannot be incorporated in a straightforward manner in outcome metrics of clinical trials e.g. aimed to assess new glycaemic-regulation therapies. To define those outcome metrics, frequent Blood Glucose (BG) reference measurements are still needed, with consequent relevant difficulties in outpatient settings. Here we propose a “retrofitting” algorithm that produces a quasi continuous time BG profile by simultaneously exploiting the high accuracy of available BG references (possibly very sparsely collected) and the high temporal resolution of CGM data (usually noisy and affected by significant bias).
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: May 28, 2019
    Assignee: DexCom, Inc.
    Inventors: Claudio Cobelli, Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino
  • Publication number: 20190059826
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Application
    Filed: October 26, 2018
    Publication date: February 28, 2019
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Patent number: 10169544
    Abstract: A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: January 1, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Marc D. Breton, Boris P. Kovatchev, Chiara Dalla Man, Claudio Cobelli, Francesco Micheletto
  • Patent number: 10143426
    Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: December 4, 2018
    Assignee: DexCom, Inc.
    Inventors: Hari Hampapuram, Anna Leigh Davis, Naresh C. Bhavaraju, Apurv Ullas Kamath, Claudio Cobelli, Giovanni Sparacino, Andrea Facchinetti, Chiara Zecchin
  • Publication number: 20180089386
    Abstract: In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor (818) at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed (822) using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 29, 2018
    Inventors: Claudio Cobelli, Giuseppe De Nicolao, Andrea Facchinetti, Stefania Guerra, Giovanni Sparacino