Patents by Inventor Claudio De Simone

Claudio De Simone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060141551
    Abstract: The use of an alkanoyl L-carnitine for preparing a medicament for treating the erectile dysfunction is described.
    Type: Application
    Filed: February 23, 2006
    Publication date: June 29, 2006
    Applicant: VSL Pharmaceuticals, Inc
    Inventor: Claudio De Simone
  • Patent number: 7052688
    Abstract: The disclosure is of a combination of lactic acid bacteria comprising: (a) a first component consisting of at least one strain of H2O2-producing lactic acid bacteria; and (b) a second component consisting of at least one strain of arginine-utilizing lactic acid bacteria. The disclosure is also of the use of this combination for making a food supplement, a hygiene product or a pharmaceutical preparation for the prevention and/or treatment of infections and inflammatory conditions caused by bacteria, viruses or fungi, especially in the mouth, vagina, urethra, nose, eyes and ears.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: May 30, 2006
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20060057132
    Abstract: The presence of a vaginal affection is determined in a subject using an identifiable indicator and, if the indication is positive, a gynecological composition comprising one or more Lactobacillus strains is administered locally in an amount effective to treat the vaginal affection. Also described are packages or kits including a probe or tool such as a glove bearing a reporter substance for indicating the presence of a vaginal infection packaged together with a gynecological composition for treating the vaginal infection, if it is found to be present.
    Type: Application
    Filed: November 9, 2005
    Publication date: March 16, 2006
    Applicant: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20050265986
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.
    Type: Application
    Filed: August 3, 2005
    Publication date: December 1, 2005
    Applicant: VSL Pharmaceutcals Inc.
    Inventors: Renata Maria Anna Cavaliere widow Vesely, Claudio De Simone
  • Patent number: 6962697
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: November 8, 2005
    Assignee: VSL Pharmaceuticals Inc.
    Inventors: Renata Maria Anna Cavaliere widow Vesely, Claudio De Simone
  • Publication number: 20050197280
    Abstract: An orally or parenterally administrable composition which comprises the following components: (a) L-carnitine inner salt or a pharmacologically acceptable salt thereof, (b) acetyl L-carnitine inner salt or a pharmacologically acceptable salt thereof; (c) ?-lipoic acid; (d) coenzyme Q10; (e) Vitamin E: and (i) selenomethionine, suitable for counteracting oxidative stress and use thereof are disclosed.
    Type: Application
    Filed: April 27, 2005
    Publication date: September 8, 2005
    Applicant: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20050186190
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Application
    Filed: April 14, 2005
    Publication date: August 25, 2005
    Applicant: VSL PHARMACEUTICALS, INC.
    Inventor: Claudio De Simone
  • Publication number: 20050186196
    Abstract: An orally or parenterally administrable composition which comprises the following components: (a) L-carnitine inner salt or a pharmacologically acceptable salt thereof, (b) acetyl L-carnitine inner salt or a pharmacologically acceptable salt thereof; (c) ?-lipoic acid; (4) coenzyme Q10; (e) Vitamin E; and (f) selenomethionine, suitable for counteracting oxidative stress and use thereof are disclosed.
    Type: Application
    Filed: April 27, 2005
    Publication date: August 25, 2005
    Inventor: Claudio De Simone
  • Patent number: 6923960
    Abstract: An orally or parenterally administrable composition which comprises the following components: (a) L-carnitine inner salt or a pharmacologically acceptable salt thereof; (b) acetyl L-carnitine inner salt or a pharmacologically acceptable salt thereof; (c) ?-lipoic acid; (d) coenzyme Q10; (e) Vitamin E; and (f) selenomethionine, suitable for counteracting oxidative stress and use thereof are disclosed.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: August 2, 2005
    Assignee: VSL Pharmaceuticals Inc.
    Inventor: Claudio De Simone
  • Publication number: 20050118152
    Abstract: An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stools of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 2, 2005
    Inventor: Claudio De Simone
  • Publication number: 20050084486
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Application
    Filed: October 15, 2004
    Publication date: April 21, 2005
    Applicant: VSL Phamaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20040259227
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7&agr;-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Application
    Filed: August 21, 2003
    Publication date: December 23, 2004
    Inventors: Renata Maria Anna Cavaliere Vesely, Claudio De Simone, Marco Vesely
  • Publication number: 20040248278
    Abstract: Describes a new strain of Streptococcus thermophilus ssp. Salivarius (deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drugs and veterinary products containing it. The use of the said strain is particularly effective in the prevention/treatment of hepatic steatosis (fatty liver) and in nonalcoholic hepatic steatosis.
    Type: Application
    Filed: April 7, 2004
    Publication date: December 9, 2004
    Inventor: Claudio De Simone
  • Publication number: 20040241149
    Abstract: Lactic acid bacteria containing unmethylated cytosine-guanine (CpG) dinucleotide are used to positively affect the immune response in a subject having or at risk of having an inflammatory response to lipopolysaccharides.
    Type: Application
    Filed: March 3, 2004
    Publication date: December 2, 2004
    Inventor: Claudio De Simone
  • Publication number: 20040071679
    Abstract: The presence of a vaginal affection is determined in a subject using an identifiable indicator and, if the indication is positive, a gynecological composition comprising one or more Lactobacillus strains is administered locally in an amount effective to treat the vaginal affection. Also described are packages or kits including a probe or tool such as a glove bearing a reporter substance for indicating the presence of a vaginal infection packaged together with a gynecological composition for treating the vaginal infection, if it is found to be present.
    Type: Application
    Filed: October 15, 2002
    Publication date: April 15, 2004
    Inventor: Claudio De Simone
  • Publication number: 20030215429
    Abstract: Disclosed is the use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction, and pharmaceutical or dietetic compositions containing such bacteria. Also disclosed is a strain of Lactobacillus brevis highly endowed with arginine deiminase.
    Type: Application
    Filed: March 28, 2003
    Publication date: November 20, 2003
    Applicant: Mendes s.r.l.
    Inventor: Claudio De Simone
  • Patent number: 6582695
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: June 24, 2003
    Assignee: VSL Pharmaceuticals Inc.
    Inventors: Renata Maria Anna Cavaliere Vesely, Claudio De Simone
  • Patent number: 6572854
    Abstract: Disclosed is the use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction, and pharmaceutical or dietetic compositions containing such bacteria. Also included is a strain of Lactobacillus brevis highly endowed with arginine deiminase.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: June 3, 2003
    Assignee: Mendes S.r.l.
    Inventor: Claudio De Simone
  • Patent number: 6562336
    Abstract: This invention provides materials and procedures for the delivery of selected strains of bacteria and/or oxalate-degrading enzymes to the intestinal tracts of persons who are at increased risk for oxalate related disease because they have lost, or have inadequate concentrations of these bacteria. The administration of these bacteria and/or the relevant enzyme removes oxalate from the intestinal tract and thus reduces the amount of oxalate available for absorption and reduces the risk for oxalate related disease.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: May 13, 2003
    Assignee: VSL Pharma Limited
    Inventor: Claudio De Simone
  • Patent number: RE39118
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatolgical and cosmetic compositions containing game which are suitable for topical application are disclosed.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: June 6, 2006
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone