Patents by Inventor Claudio De Simone

Claudio De Simone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030086917
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.
    Type: Application
    Filed: December 3, 2002
    Publication date: May 8, 2003
    Applicant: VSL Pharmaceuticals Inc.
    Inventors: Renata Maria Anna Cavaliere widow Vesely, Claudio De Simone
  • Publication number: 20030082791
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7&agr;-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Application
    Filed: June 18, 2002
    Publication date: May 1, 2003
    Inventor: Claudio De Simone
  • Publication number: 20030077269
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.
    Type: Application
    Filed: May 22, 2001
    Publication date: April 24, 2003
    Applicant: VSL Pharmaceuticals Inc.
    Inventors: Renata Maria Anna Cavaliere Vesely, Claudio De Simone
  • Publication number: 20030068309
    Abstract: An orally or parenterally administrable composition which comprises the following components:
    Type: Application
    Filed: October 3, 2001
    Publication date: April 10, 2003
    Inventor: Claudio De Simone
  • Patent number: 6544568
    Abstract: The present invention relates to a functional food/health food in the form of a baked good comprising a non-baked fat-based composition and a baked part, characterized in that the fat-based composition is essentially water-free and comprises live lyophilized lactic bacteria and in that the baked part comprises one or more non-digestible fiber-like substances. Also provided are intermediates thereof, a method for its production and its use.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: April 8, 2003
    Assignee: VSL Pharmaceuticals Inc.
    Inventors: Philippe La Droitte, Claudio De Simone
  • Publication number: 20020192276
    Abstract: The use of G class immunoglobulins, particularly immunoglobulins for intravenous use or for intramuscular use to produce a medicine for the local therapeutic treatment of dermatitis, particularly acne, contact dermatitis, atopic dermatitis, eczema and ichthyosis, psoriasis papulosquamous dermatopathies (seborrehic dermatitis, erythrodermia, etc.), as well as fungus, parasite, bacterium and virus infection dermatitis is disclosed. The pharmaceutical composition containing G class immunoglobulins suitable for topical application for the treatment of dermatitis is also disclosed.
    Type: Application
    Filed: May 20, 2002
    Publication date: December 19, 2002
    Applicant: Mendes S.R.L.
    Inventors: Claudio De Simone, Pietro Bruschi
  • Publication number: 20020094328
    Abstract: The disclosure is of a combination of lactic acid bacteria comprising: (a) a first component consisting of at least one strain of H2O2-producing lactic acid bacteria; and (b) a second component consisting of at least one strain of arginine-utilizing lactic acid bacteria. The disclosure is also of the use of this combination for making a food supplement, a hygiene product or a pharmaceutical preparation for the prevention and/or treatment of infections and inflammatory conditions caused by bacteria, viruses or fungi, especially in the mouth, vagina, urethra, nose, eyes and ears.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 18, 2002
    Inventor: Claudio De Simone
  • Patent number: 6410019
    Abstract: The use of G class immunoglobulins, particularly immunoglobulins for intravenous use or for intramuscular use to produce a medicine for the local therapeutic treatment of dermatitis, particularly acne, contact dermatitis, atopic dermatitis, eczema and ichthyosis, psoriasis, papulosquamous dermatopathies (seborrehic dermatitis, erythrodermia, etc.), as well as fungus, parasite, bacterium and virus infection dermatitis is disclosed. The pharmaceutical composition containing G class immunoglobulins suitable for topical application for the treatment of dermatitis is also disclosed.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: June 25, 2002
    Assignee: Mendes s.u.r.l.
    Inventors: Claudio De Simone, Pietro Bruschi
  • Publication number: 20020061292
    Abstract: This invention provides materials and procedures for the delivery of selected strains of bacteria and/or oxalate-degrading enzymes to the intestinal tracts of persons who are at increased risk for oxalate related disease because they have lost, or have inadequate concentrations of these bacteria. The administration of these bacteria and/or the relevant enzyme removes oxalate from the intestinal tract and thus reduces the amount of oxalate available for absorption and reduces the risk for oxalate related disease.
    Type: Application
    Filed: November 26, 2001
    Publication date: May 23, 2002
    Inventor: Claudio De Simone
  • Patent number: 6380252
    Abstract: A method is provided for increasing the levels of IGF-1 for the therapeutic treatment or prophylaxis of cytological disorders or diseases related to IGF-1 selected from the group including neuropathies of the optic nerve and of the olfactory nerve, neuralgia of the trigmeninal nerve, Bell's paralysis, amyotrophic lateral sclerosis, osteoporosis, anthropathy, arthritis, cervical spondylosis and hernia of the intervertebral discs clinical syndromes of reduced height, cachexia and acute or chronic hepatic necrosis, Turner's syndrome, sarcopoenia, growth hormone insensitivity syndromes, obesity, asthenia, myasthenia and heart asthenia, immunodeficiences and reperfusion injuries, and for the cicatrization of wounds, the healing of ulcers, the treatment of burns, tissue regeneration, cutaneous, intestinal and hepatic tissue regeneration and the formation of dentine, that includes administering, to a patient in need thereof, at least one selected from the group including L-acetylcarnitine, L-isovalerylcarn
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: April 30, 2002
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Mendes S.R.L.
    Inventor: Claudio De Simone
  • Publication number: 20020031507
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Application
    Filed: September 24, 2001
    Publication date: March 14, 2002
    Applicant: MENDES S.R.L. UNIPERSONALE (MENDES S.U.R.L.)
    Inventor: Claudio De Simone
  • Patent number: 6326000
    Abstract: Enteral compositions containing Streptococcus thermophilus, Bifidobacterium infantis and Bifidobacterium longum, each at a concentration equal to or greater than 1×1011 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by the other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff. The present invention relates to a kit comprising two containers, one containing a foodstuff and the other containing the enteral composition consisting of Streptococcus thermophilus, Bifidobacterium infantis and Bifidobacterium longum.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: December 4, 2001
    Inventors: Renata Maria Anna Cavaliere ved. Vesely, Claudio De Simone
  • Patent number: 6277370
    Abstract: Use of an association of lactobacilli for preparation of a pharmaceutical composition for treatment of vaginosis and vaginitis. Said bacteria association comprises the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, possibly in combination with one or more species selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri. A pharmaceutical composition comprising said association of lactobacilli adapted for treatment of vaginosis and vaginitis. A method of treating vaginosis and vaginitis based on administration of said pharmaceutical composition.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: August 21, 2001
    Inventors: Renata Maria Anna Cavaliere Ved. Vesely, Claudio De Simone
  • Publication number: 20010012629
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7&agr;-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Application
    Filed: March 2, 2001
    Publication date: August 9, 2001
    Inventors: Renata Maria Anna Cavaliere Vesely, Claudio De Simone
  • Patent number: 6258355
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatolgical and cosmetic compositions containing game which are suitable for topical application are disclosed.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: July 10, 2001
    Assignee: VSL Pharmaceuticals Inc.
    Inventors: Renata Maria Anna Cavaliere widow Vesely, Claudio De Simone
  • Patent number: 6225104
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7&agr;-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: May 1, 2001
    Inventors: Renata Maria Anna Cavaliere Vesely, Claudio De Simone
  • Patent number: 6166077
    Abstract: A method is provided for increasing the levels of IGF-1 for the therapeutic treatment or prophylaxis of cytological disorders or diseases related to IGF-1 selected from the group including neuropathies of the optic nerve and of the olfactory nerve, neuralgia of the trigmeninal nerve, Bell's paralysis, amyotrophic lateral sclerosis, osteoporosis, anthropathy, arthritis, cervical spondylosis and hernia of the intervertebral discs clinical syndromes of reduces height, cachexia and acute or chronic hepatic necrosis, Turner's syndrome, sarcopoenia, growth hormone insensitivity syndromes, obesity, asthenia, myasthenia and heart asthenia, immunodeficiencies and reperfusion injuries, and for the cicatrization of wounds, the healing of ulcers, the treatment of burns, tissue regeneration, cutaneous, intestinal and hepatic tissue regeneration and the formation of dentine, that includes administering, to a patient in need thereof, at least one selected from the group including L-acetylcarnitine, L-isovalerylcarnitine, an
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: December 26, 2000
    Assignees: Sigma-TAU Industrie Farmaceutiche Riunite S.p.A., Mendes S.r.l.
    Inventor: Claudio De Simone
  • Patent number: 6077504
    Abstract: Enteral compositions containing a mixture of live lactic bacteria consisting of Streptococcus thermophilus, Bifidobacterium longum and Bifidobacterium infantis, each at a concentration equal to or greater than 1.times.10.sup.11 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by the other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: June 20, 2000
    Inventors: Renata Maria Anna Cavaliere ved. Vesley, Claudio De Simone
  • Patent number: 6037373
    Abstract: A method is provided for increasing the levels of IGF-1 for the therapeutic treatment or prophylaxis of cytological disorders or diseases related to IGF-1 selected from the group consisting of neuropathies of the optic nerve and of the olfactory nerve, neuralgia of the trigeminal nerve, Bell's paralysis, amyotrophic lateral sclerosis, osteoporosis, arthropathy, arthritis, cervical spondylosis and hernia of the intervertebral discs, clinical syndromes of reduced height, cachexia and acute or chronic hepatic necrosis, Turner's syndrome, sarcopoenia, growth hormone insensitivity syndromes, obesity, asthenia, myasthenia and heart asthenia, immunodeficiencies and reperfusion injuries, and for the cicatrization of wounds, the healing of ulcers, the treatment of burns, tissue regeneration, cutaneous, intestinal and hepatic tissue regeneration and the formation of dentine, that includes administering, to a patient in need thereof, at least one selected from the group consisting of L-acetylcarnitine, L-isovalerylcarni
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: March 14, 2000
    Assignees: SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A., MENDES s.r.l.
    Inventor: Claudio De Simone
  • Patent number: 5719192
    Abstract: A method of use comprising administering terbinafine for the primary and secondary prophylaxis and treatment of Pneumocystis carinii pneumonia, including oral administration of terbinafine at does of 3 to 20 mg/kg/day, to a subject suffering from this type of pneumonia is disclosed.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: February 17, 1998
    Assignee: Mendes s.r.l.
    Inventors: Claudio De Simone, Carlo Contini, Sonia Tzoutzoglou