Abstract: Method to manufacture a component suitable to be installed inside a protected chamber with a controlled atmosphere of a machine for the production and/or packaging of pharmaceutical products, configured to receive one or more pieces of equipment, or devices, or elements, each formed by one or more of the components, wherein the interior of the chamber, that is to say, the components that form the equipment, or the devices, or the elements, is/are intended to be subjected to suitable decontamination and sterilization treatments, for example CIP (Clean-In-Place) treatments and/or SIP (Sterilizing-In-Place) treatments; There are also described components that are manufactured with the manufacturing method as above, and a method to prepare a protected chamber, isolated from the external environment, of a machine for the production and/or packaging of pharmaceutical products.

Abstract: A positive displacement pump, including at least a cylinder, provided with at least an entrance aperture and at least an exit aperture for the liquid and a plunger, mobile inside the cylinder by means of a first actuator and configured to transfer the liquid from the entrance aperture to the exit aperture; the cylinder is provided with at least a first inactive position and at least a second working position between which it can be selectively positioned in an automatic and adjustable manner by at least one second actuator.

Abstract: An opening assembly for a package, particularly for containers including vials, bottles, syringes, and carpules which can be installed in a container handling and filling system. The package includes a tub covered by a covering film, the tub containing a nest bearing the containers in an orderly manner. The opening assembly includes at least one clamp located upstream of an opening placed on a separation wall between a first and second sterile environment. While the package passes through the opening, the clamp clamps a portion of an edge of the covering film, consequently removing the covering film from the tub.

Abstract: A fan assembly for cleanrooms includes a chamber defined by a floor, two opposing side walls and an upper wall, an inlet unit for introducing a laminar stream of gas into said chamber directed towards the floor, said chamber being arranged in such a way as to be internally invested by the gas introduced by the inlet unit, where said assembly further includes a conveying channel for the gas and for liquid substances present within the chamber positioned on the floor, said conveying channel is surmounted by a casing defined by an upper wall and by two opposing side walls and each side wall of the casing, being provided with through openings that place the chamber into communication with the conveying channel, said opposing side walls of the casing are arranged spaced apart from the respective opposing side walls of the chamber.

Abstract: A machine for filling and packaging containers including but not limited to bottles, cartridges, and syringes includes a wall that delimits an operating chamber in which at least one handling arm is arranged and which is facing at least one station placed externally to the operating chamber for the treatment of one or more of the containers. An intermediate element includes at least one coupling member configured to be alternatively operatively associable to the station and to the handling arm, with the intermediate element further including a coupling assembly integral to the intermediate element itself and different than coupling member. The coupling assembly is configured to removably hold one or more of the containers to be treated.

Abstract: A machine to fill and weigh containers (100) is described, comprising at least one movement device (18) configured to transport one or more containers (100) between at least two work stations (12) disposed in a work direction (F) which defines a movement path between said at least two work stations (12), wherein along the movement path at least one weighing device (17) is present to acquire the measurement of the mass of said one or more containers (100). A method to weigh the containers (100) is also described, actuated in the machine to fill and weigh containers as above.

Abstract: A machine (10) to automatically transport, from and to one or more working stations (12), one or more components (11) to make a package, comprises a reference surface (13), with which electric energizing members (14) are associated to selectively generate one or more magnetic fields, and at least a pair of support members (15) each provided with magnetic means (16) configured to interact with the magnetic fields. The machine (10) comprises control means (17) configured to energize selectively and in a coordinated manner the electric energizing members (14) to cause the selective movement of each support member (15) from one point to another of the reference surface (13).

Abstract: Method to weigh containers (C) in a processing line (10) which comprises a filling and weighing station (12) for said containers (C), said method providing to make available a plurality of containers (C) which are initially weighed in order to determine the tare weight and subsequently filled sequentially, determining the weight of the product metered into each container (C).

Abstract: An extraction assembly for extracting content from a bag, said bag having an end mouth formed by two opposing flaps, comprising a separation wall which separates a first environment and a second environment at different contamination classes and which is provided with an opening communicating the first environment and the second environment, closing partitions at the opening movable between a closing position and an opening position, and a gripper to keep closed said flaps and wherein each closing partition has coupling elements to couple with a gripper, wherein said gripper and said coupling elements include a retention device, the spacing apart of partitions causing opening of the jaws and the opening of the end mouth and the communicating of the inside of the bag and of the content with said second environment through said opening.

Abstract: Method to manufacture a component suitable to be installed inside a protected chamber with a controlled atmosphere of a machine for the production and/or packaging of pharmaceutical products, configured to receive one or more pieces of equipment, or devices, or elements, each formed by one or more of the components, wherein the interior of the chamber, that is to say, the components that form the equipment, or the devices, or the elements, is/are intended to be subjected to suitable decontamination and sterilization treatments, for example CIP (Clean-In-Place) treatments and/or SIP (Sterilizing-In-Place) treatments; There are also described components that are manufactured with the manufacturing method as above, and a method to prepare a protected chamber, isolated from the external environment, of a machine for the production and/or packaging of pharmaceutical products.

Abstract: A conveyor assembly for packages of containers for pharmaceutical use which include an outer bag. The assembly includes a handling line for gripping elements and a dispensing apparatus for a laminar flow of gas positioned above the top of the line and directed towards the line itself. Each gripping element includes at least one clamping jaw for at least one flap of said bag to hang it so that each of its outer surfaces is invested by the laminar flow of gas during its handling.

Abstract: A machine for filling and packaging bottles, cartridges, syringes and the like, said machine including a wall that delimits an operating chamber in which at least one handling arm is arranged, substantially facing at least one station placed externally to the operating chamber for the treatment of at least a container. At least one intermediate element includes, on at least a portion thereof, at least one coupling member configured to be alternatively operatively associable to said station and to said handling arm, said intermediate element further including comprising coupling means, integral to the intermediate element itself, other than said coupling member and configured to removably hold said at least one container to be treated.

Abstract: An opening assembly for bags housing containers for pharmaceutical use, including at least one clamping mechanism for clamping a portion of said bag spaced apart with respect to an end flap of the bag, said clamping mechanism arranged so as to clamp together sections of opposing sheets of said bag, and at least one cutting element for the trimming and the separation of said end flap with respect to said sections of said opposing sheets of said bag mutually clamped together by said clamping mechanism.

Abstract: A fan assembly for cleanrooms includes a chamber defined by a floor, two opposing side walls and an upper wall, an inlet unit for introducing a laminar stream of gas into said chamber directed towards the floor, said chamber being arranged in such a way as to be internally invested by the gas introduced by the inlet unit, where said assembly further includes a conveying channel for the gas and for liquid substances present within the chamber positioned on the floor, said conveying channel is surmounted by a casing defined by an upper wall and by two opposing side walls and each side wall of the casing, being provided with through openings that place the chamber into communication with the conveying channel, said opposing side walls of the casing are arranged spaced apart from the respective opposing side walls of the chamber.

Abstract: A method for weighing containers arranged inside a holding structure includes providing a holding structure suitable to house in a substantially stable position at least one container, said at least one container including a supporting portion shaped so as to keep the container suspended on the holding structure, bringing said at least one container to a weighing station including a weighing member suitable to weight said at least one container, weighing said at container by means of said weighing member; wherein the weighing step is carried out by moving the holding structure so as to put said at least one container housed inside the holding structure in contact with the weighing member kept in a stationary position, until the detachment of the supporting portion of said at least one container from the holding structure is obtained.

Abstract: A dosing apparatus for dosing a powder product inside containers includes a hopper provided with an inner cavity for containing the product, a lower portion provided with a supply duct with a terminal aperture for the outflow of the product, a metering screw rotating inside the supply duct and a washing manifold provided with an inlet opening and containing at least a sonotrode. In a cleaning configuration of the dosing apparatus, the washing manifold is connected to the hopper coupling the inlet opening to the supply duct, so as to receive and contain a washing liquid introduced in the hopper. The sonotrode is activated to produce alternate pressure waves capable of generating in the washing liquid air bubbles adapted to propagate towards the inner cavity through the supply duct, and to implode thus creating shock waves.

Abstract: A positive displacement pump, including at least a cylinder, provided with at least an entrance aperture and at least an exit aperture for the liquid and a plunger, mobile inside the cylinder by means of a first actuator and configured to transfer the liquid from the entrance aperture to the exit aperture; the cylinder is provided with at least a first inactive position and at least a second working position between which it can be selectively positioned in an automatic and adjustable manner by at least one second actuator.

Abstract: A movement apparatus for loading/unloading containers (100) into/from a freeze-dryer (50) provided with a freeze drying chamber (51) that has at least one shelf (52) for receiving and supporting containers (100), comprising a push bar (2) to push the containers (100) and a movement arrangement (3) for moving the push bar (2) through the freeze drying chamber (51) along a direction of movement (A); the movement arrangement (3) comprises at least one rigid interlocking chain linear actuator (4) that has a first movement rigid interlocking chain (43) mobile along the direction of movement (A) and provided with a first operating end (14) connected to the push bar (2).

Abstract: A transferring device is provided for transferring containers from a container advancing device, where they are aligned in at least one row along an advancing direction, to at least one operating unit arranged outside the line, adjacent to the container advancing device, along a transferring direction transverse to the advancing direction. The transferring device includes at least two transferring arms, movable to selectively translate along the transferring direction from the container advancing device toward the operating unit.

Abstract: A dosing apparatus for dosing a product in powder and/or granule form within containers includes a hopper (2) provided with an internal cavity (3) to contain the product, a dosing screw (4) rotatable about, and extending along, a rotation axis (X) inside the hopper and through the internal cavity, and a first driving shaft (5) arranged to rotate the dosing screw; the dosing apparatus also includes a magnetic coupling system (10) to removably connect a first end (6) of the dosing screw (4) to the first driving shaft (5), arranged externally to the hopper (2); the magnetic coupling system includes groups of magnets (21, 22, 23, 24) adapted to magnetically transmit a driving torque from the first driving shaft (5) to the dosing screw (4) and to reversibly fasten, longitudinally along the rotation axis (X), the dosing screw (4) to the first driving shaft (5); the first end (6) of the dosing screw (4) is arranged inside the hopper (2) and the first driving shaft (5) is hermetically separated from the first end (6)