Abstract: A stent may be actuatable between a delivery configuration and a deployed configuration. A stent may include one or more interwoven filaments each including a cross-sectional profile having at least one flattened portion. A flattened portion of a first filament portion of the one or more filaments may be positioned in contact with a flattened portion of a second filament portion of the one or more filaments.

Abstract: A device for closing a tissue opening includes a body extending from a first end to a second end and a first anchoring element connected to the first end of the body and a second anchoring element connected to the second end of the body. At least one of the first anchoring element and the second anchoring element is movable between an insertion configuration, in which the at least one of the first and second anchoring elements is insertable through a target tissue such that the body extends across a tissue opening to be treated, and an anchoring configuration, in which the first and second anchoring elements engage target tissue on a first side and a second side, respectively, of the tissue opening.

Abstract: A device for closing a tissue opening includes a body extending from a first end to a second end and a first anchoring element connected to the first end of the body and a second anchoring element connected to the second end of the body. At least one of the first anchoring element and the second anchoring element is movable between an insertion configuration, in which the at least one of the first and second anchoring elements is insertable through a target tissue such that the body extends across a tissue opening to be treated, and an anchoring configuration, in which the first and second anchoring elements engage target tissue on a first side and a second side, respectively, of the tissue opening.

Abstract: A stent delivery device is provided that includes an inner member defining a distal tip and a stent holding region, and an outer tubular member slidingly disposed over the inner member and configured to engage the distal tip. Seal members may be disposed on one or more of an outer surface of the inner member, the distal tip, and the outer tubular member. The seal members define a liquid-tight sealed chamber surrounding the stent holding region.

Abstract: A method of loading an expandable stent into a delivery device may include positioning a middle portion of the expandable stent in a collapsing fixture including a passage extending therethrough, radially compressing the middle portion of the expandable stent in the passage before any other portion of the expandable stent while a first end of the expandable stent is disposed outside of the passage, moving the collapsing fixture relative to the expandable stent, radially compressing the expandable stent from the middle portion toward the first end of the expandable stent, and inserting the first end of the expandable stent followed by the middle portion of the expandable stent into a distal end of an elongate outer sheath of the delivery device.

Abstract: A stent delivery device is provided that includes an outer tubular member, an intermediate tubular member disposed and slidable within a lumen of the outer tubular member, and a plurality of elongate members slidable within the intermediate tubular member. The plurality of elongate members have distal end structures that are moveable between a stent retaining configuration to selectively retain a stent and a stent releasing configuration to selectively release the stent.

Abstract: Apparatuses for manipulating a collapsible medical device include a sheath, a first shaft including a first grasping member and a second grasping member. The second grasping member is separated from the first grasping member by a distance. The collapsible medical device may be manipulated by actuating the first grasping member and the second grasping member and by increasing the distance between the first grasping member and the second grasping member. Methods of using the apparatuses are provided.

Abstract: A medical device is disclosed which includes a delivery member having at least two lumens extending within. Each lumen may include a rotational element within. Each rotational element may be configured to convert linear motion into rotational motion. The medical device may also include a snare element including a distal snare loop and two proximally extending legs. Each leg of the snare element may be within one of the two lumens. Further, the rotational element in a first lumen may be configured to impart a clock-wise rotation to a first leg of the two proximally extending legs, while the rotational element in a second lumen of the at least two lumens may be configured to impart a counter clock-wise rotation to a second leg of the two proximally extending legs.

Abstract: A stent delivery device for deploying a low column strength stent may include an inner member having a distal region and a stent receiving area disposed therein. A low column strength stent convertible between a compressed configuration and an expanded configuration may be disposed on the stent receiving area. The stent receiving area may include a soft durometer polymer configured to permit the low column strength stent to sink into the soft durometer polymer when the low column strength stent is in the compressed configuration. An outer member may be moveable between an extended position in which the outer member extends over the stent and a retracted position in which the outer member is proximal of the stent.

Abstract: A medical device includes a handle, a flexible member extending from a proximal end connected to the handle to a distal end, a rotation mechanism connected to the distal end of the flexible member, an end effector coupled to a distal portion of the rotation mechanism and a push member extending through the handle and flexible member and connecting to the rotation mechanism, the rotation mechanism being configured and dimensioned to convert axial movement of the push member into rotation of the end effector.

Abstract: A stent may be actuatable between a delivery configuration and a deployed configuration. A stent may include one or more interwoven filaments each including a cross-sectional profile having at least one flattened portion. A flattened portion of a first filament portion of the one or more filaments may be positioned in contact with a flattened portion of a second filament portion of the one or more filaments.

Abstract: A system for inserting an element into a target tissue includes an endoscope comprising a working channel extending therethrough and an end cap comprising a cavity extending therein from an open proximal end sized to receive a distal end of the endoscope therein and a closed distal end. The cavity is open to an exterior of the end cap via a window extending laterally through a side wall thereof so that a target tissue may be received within the cavity via the window. The system also comprises a needle sized to be passed through the working channel of the endoscope so that a distal end of the needle is insertable into the cavity thereby, the needle extending longitudinally from a proximal end to a distal end and comprising a lumen for housing an element to be delivered to the target tissue.

Abstract: Stent delivery systems and methods for making and using stent delivery systems are disclosed. An example stent delivery system may include an inner shaft. A deployment sheath may be disposed about the inner shaft. A stent may be disposed between the inner shaft and the deployment sheath. A stent reconstraining member may be secured to an inner surface of the deployment sheath and releasably secured to the stent.

Abstract: A tubular prosthesis that includes a scaffolding formed by at least one scaffolding filament; a cover; and at least one controlled ingrowth feature constructed and arranged to abut an inner surface of a lumen wall when the prosthesis is implanted in the body lumen. The controlled ingrowth feature may extend inwards or outwards from the prosthesis outer surface. The controlled ingrowth feature may be formed by a scaffolding filament; by a separate filament; by the cover; and combinations thereof.

Abstract: A device for closing a tissue opening includes a body extending from a first end to a second end and a first anchoring element connected to the first end of the body and a second anchoring element connected to the second end of the body. At least one of the first anchoring element and the second anchoring element is movable between an insertion configuration, in which the at least one of the first and second anchoring elements is insertable through a target tissue such that the body extends across a tissue opening to be treated, and an anchoring configuration, in which the first and second anchoring elements engage target tissue on a first side and a second side, respectively, of the tissue opening.

Abstract: The present disclosure is directed to a delivery catheter with a mechanism of discharging an adhesive during and/or immediately prior to deployment of the medical device by the delivery catheter.

Abstract: A stent has a braided wire body formed from at least a first wire and a second wire. The first wire has a first cross-sectional area and the second wire has a second cross-sectional area different from the first cross-sectional area. The proximal end of the braided wire body has a plurality of peaks, the peaks including first peaks and first loop ends. The first loop ends alternate circumferentially with the first peaks and the first loop ends extend proximally beyond the first peaks.

Abstract: Apparatuses for manipulating a collapsible medical device include a sheath, a first shaft including a first grasping member and a second grasping member. The second grasping member is separated from the first grasping member by a distance. The collapsible medical device may be manipulated by actuating the first grasping member and the second grasping member and by increasing the distance between the first grasping member and the second grasping member. Methods of using the apparatuses are provided.

Abstract: A medical device is disclosed which includes a delivery member having at least two lumens extending within. Each lumen may include a rotational element within. Each rotational element may be configured to convert linear motion into rotational motion. The medical device may also include a snare element including a distal snare loop and two proximally extending legs. Each leg of the snare element may be within one of the two lumens. Further, the rotational element in a first lumen may be configured to impart a clock-wise rotation to a first leg of the two proximally extending legs, while the rotational element in a second lumen of the at least two lumens may be configured to impart a counter clock-wise rotation to a second leg of the two proximally extending legs.