Abstract: In some embodiments, apparatuses and methods are provided herein useful to orthodontic appliances. In some embodiments, an orthodontic appliance comprises a main body portion including a first end and a second end, wherein the first end is opposite the second end, the main body portion comprising a first orthodontic device, wherein the first orthodontic device is configured to be bonded to a first tooth of a patient's mouth, and wherein the first orthodontic device is located to proximal the first end, and an eyelet, wherein the eyelet is located proximal to the second end, and a second orthodontic device, wherein the second orthodontic device is configured to be bonded to a second tooth of the patient's mouth, wherein the second orthodontic device includes a protrusion, and wherein the protrusion is located within the eyelet during use in the patient's mouth.

Abstract: In some embodiments, systems, apparatuses, and methods are provided herein useful to orthodontic systems. In some embodiments, an orthodontic system comprises a carrier structure comprising a base, a plurality of groups of support structures, a plurality of orthodontic appliances associated with one of the plurality of groups of support structures, and at least one rail extending from the base, and an assembly structure comprising a body, a plurality of complementary pieces associated with one of the plurality of orthodontic appliances, at least one channel configured to interface with the at least one rail to allow the assembly structure to be moved from a first position to a second position with respect to the carrier structure, wherein movement of the assembly structure with respect to the carrier structure causes the plurality of complementary pieces to mate with the plurality of orthodontic appliances.

Abstract: An automatic injector dispenses a predetermined dose of medicament without a user having to manually force the needle into an injection site. The automatic injector includes a needle cover having a locked retracted position with respect to the injector housing prior to a medicament dispensing operation. The needle cover is operative to engage an injection site prior to a medicament dispensing operation.

Abstract: The present disclosure relates to complexes and compositions of cationic compounds combined with low mass percentages of PEGylated compounds, such as PEGylated lipids, for the delivery of nucleic acids and other polyanionic cargoes to cells, methods for preparing complexes and compositions comprising one or more cationic compounds and a low mass percentage of PEGylated compounds with polyanionic compounds, and methods for delivering the polyanionic compounds to cells.

Abstract: A system and method for intelligent self-calibration of target load thresholds for users of exercise machines is disclosed herein. In one embodiment, a method includes determining, by one or more processing devices, a bone geometry of a bone in a portion of a body of a user, where said portion is going to be exercised by the user performing an exercise on an exercise machine. The method also includes determining, using the bone geometry, a strain on the bone in the portion of the body of the user such that the strain triggers osteogenesis, determining a target load threshold to be added by the user to the exercise machine during the exercise to achieve the strain that triggers osteogenesis, and, while the user performs the exercise on the exercise machine, causing the target load threshold to be represented on a user interface of a computing device.

Abstract: The present disclosure relates to lipid mixtures comprising lipidated cationic peptide compounds, such as tertiary amino lipidated and/or PEGylated cationic peptide compounds or lipitoids, for nucleic acid delivery. More specifically, the present disclosure relates to lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids. The present disclosure also relates to methods of preparing and using the lipid mixtures.

Abstract: A system for query optimization by a federation engine is provided. When a data source supports a target feature of an expression of a query in the common query language, the system executes a converter for the data source to convert the target feature to the corresponding feature of the data source query language. The system then submits to the data source a query with the expression with the converted target feature so that the expression is evaluated at the data source and receives query results. When a data source does not support the target feature of the expression, the system submits to the data source a query without the expression and evaluates the expression on the query results returned by the data source. The system then combines the query results based on the evaluation of the expression as the query results of the query.

Abstract: In some embodiments, apparatuses, and methods are provided herein pertaining to orthodontic devices. In some embodiments, a hybrid attachment for orthodontic use comprises a body, wherein the body comprises an archwire slot, wherein the archwire slot is configured to receive an archwire, a bonding surface, wherein the bonding surface is configured to bond to a facial surface of a patient's tooth via an adhesive, and wherein the bonding surface is located on a first side of the body, and a facial surface, wherein the facial surface has a nonnegative draft normal to the facial surface of the patient's tooth, wherein the facial surface is configured to releasably retain a removable orthodontic aligner, and wherein the facial surface is located on a second side of the body.

Abstract: A molded container assembly includes a pallet, a molded container, and a plurality of connection systems. The pallet supports the molded container thereon and includes stacking alignment structure for stacking the pallet on another molded container assembly. The molded container includes a tank portion, several leg supports, several buttresses, and several horizontally extending ribs. The tank portion includes several curved sidewalls and a fill opening. The leg supports include lower and upper sections that extend above the fill opening for spacing a pallet stacked on top of the molded container above the fill opening. The upper sections include pallet engaging structure for engaging pallets of at least two different types. The horizontally extending ribs minimize outward deflection due to hydrostatic loading and/or pressurization. The connection systems include washers that allow for shrinkage and expansion between the molded container and the pallet in a number of directions.

Abstract: A method of inspecting a component using an image retrieval module includes storing an inspection image file in a memory and identifying a region of interest in the inspection image file. The method further includes accessing a database storing image files and determining feature vectors associated with the image files. The method also includes determining a hash code for each image file based on the feature vectors and classifying a subset of image files as relevant based on the hash codes. The method further includes sorting the subset of image files based on the feature vectors and generating search results based on the sorted subset of image files. The image retrieval module includes a convolutional neural network configured to learn from the determination of the feature vectors and increase the accuracy of the image retrieval module in classifying the image files.

Abstract: A method of inspecting a component includes storing at least one inspection image file in a memory and receiving a search request associated with the at least one inspection image file. The method also includes accessing a database including a plurality of image files, comparing the hash code of the at least one inspection image file to the hash code of each image file of the plurality of image files, and identifying a first subset of image files based on the hash code comparison. The method also includes comparing the feature data of the at least one inspection image file to the feature data of each image file of the first subset of image files and classifying a second subset of image files as relevant based on the feature data comparison. The method further includes generating search results based on the second subset of image files.

Abstract: A well advisor system and console for monitoring and managing pressure testing operations at a well site. The system may be accessed through one or more workstations, or other computing devices, which may be located at a well site or remotely. The system is in communication with and receives input from various sensors. It collects real-time sensor data sampled during operations at the well site. The system processes the data, and provides nearly instantaneous numerical and visual feedback through a variety of graphical user interfaces (“GUIs”), which are presented in the form of an operation-specific console. The input and data provides information related to pressure testing at a well site.

Abstract: Systems, methods, and computer readable medium are provided for automatically resetting a zero-offset calibration coefficient for a pressure transducer. Ambient pressure measurements from a first pressure sensor and a second pressure sensor can be received by a computing device and compared. Based on determining a difference in the received ambient pressure measurements, an updated zero-offset calibration coefficient can be generated. The updated zero-offset calibration coefficient can be transmitted to the first pressure sensor, which once received, causes the first pressure sensor to update a previously determined zero-offset calibration coefficient with the updated zero-offset calibration coefficient.

Abstract: The present disclosure relates to lipid mixtures comprising lipidated cationic peptide compounds, such as tertiary amino lipidated and/or PEGylated cationic peptide compounds or lipitoids, for nucleic acid delivery. More specifically, the present disclosure relates to lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids. The present disclosure also relates to methods of preparing and using the lipid mixtures.

Abstract: The present disclosure relates to tertiary amino lipidated and/or PEGylated cationic peptide compounds and complexes thereof with nucleic acids for endocellular delivery, methods for preparing the compounds and complexes, and methods for delivering polyanionic compounds to cells.

Abstract: The present disclosure relates to lipid mixtures comprising lipidated cationic peptide compounds, such as tertiary amino lipidated and/or PEGylated cationic peptide compounds or lipitoids, for nucleic acid delivery. More specifically, the present disclosure relates to lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids. The present disclosure also relates to methods of preparing and using the lipid mixtures.

Abstract: The present disclosure relates to tertiary amino lipidated and/or PEGylated cationic peptide compounds and complexes thereof with nucleic acids for endocellular delivery, methods for preparing the compounds and complexes, and methods for delivering polyanionic compounds to cells.

Abstract: A molded container assembly including a pallet, a molded container, and a plurality of connection systems. The pallet supports the molded container thereon and includes stacking alignment structure for stacking the pallet on another molded container assembly. The molded container includes a tank portion, several leg supports, and several buttresses. The tank portion includes several curved sidewalls and a fill opening. The leg supports include lower sections and upper sections that extend above the fill opening for spacing a pallet stacked on top of the molded container above the fill opening. The upper sections include pallet engaging structure for engaging pallets of at least two different types. The buttresses extend between the tank portion and the leg supports. The connection systems include washers that allow for shrinkage and expansion between the molded container and the pallet in a number of directions.

Abstract: A method of inspecting a component using an image inspection controller that includes a processor communicatively coupled to a memory includes classifying each sample image in a first database as a first sample or a second sample using a classification module, extracting at least one class generic feature from each first sample to generate a plurality of class generic features, and extracting at least one class specific feature from each second sample to generate a plurality of class specific features. The method further includes combining the class generic features and the class specific features to generate a plurality of supplemental images. The method further includes storing the sample images and the supplemental images in a second database, classifying each sample image and each supplemental image, capturing at least one image of the component using a camera, and identifying at least one feature of the component in the at least one image of the component using the classification module.

Abstract: A well advisor system and console for monitoring and managing well drilling and production operations. The system may be accessed through one or more workstations, or other computing devices, which may be located at a well site or remotely. The system is in communication with and receives input from various sensors. It collects real-time sensor data sampled during operations at the well site. The system processes the data, and provides nearly instantaneous numerical and visual feedback through a variety of graphical user interfaces (“GUIs”), which are presented in the form of an operation-specific console. The input and data provides information related to geologic uncertainty concerning a well being drilled, with a focus on the safety of the drilling operation.