Patents by Inventor Colin Marshall
Colin Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8833376Abstract: The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibers or films, and converting the fibers or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.Type: GrantFiled: September 17, 2010Date of Patent: September 16, 2014Assignee: Innovia Films LimitedInventors: Colin Marshall, Jamie Moffat
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Publication number: 20140221359Abstract: Described are methods of prepraing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.Type: ApplicationFiled: April 9, 2014Publication date: August 7, 2014Applicant: Wis Ta Laboratories Ltd.Inventors: Claude Michel WISCHIK, Janet Elizabeth Rickard, Charles Robert Harrington, David Horsley, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Patent number: 8722162Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: GrantFiled: June 8, 2010Date of Patent: May 13, 2014Assignee: Innovia Films LimitedInventors: Alastair Hugh Servante, Gary Power, Colin Marshall
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Patent number: 8710051Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of the following formula: wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methylthioninium chloride, MTC).Type: GrantFiled: January 21, 2011Date of Patent: April 29, 2014Assignee: Wis Ta Laboratories Ltd.Inventors: Claude Michel Wischik, Janet Elizabeth Rickard, Charles Robert Harrington, David Horsley, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Patent number: 8691979Abstract: Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).Type: GrantFiled: May 11, 2010Date of Patent: April 8, 2014Assignee: Wista Laboratories Ltd.Inventors: Christopher Paul Larch, John Mervyn David Storey, Craig Williamson, Colin Marshall, Steven John Kemp
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Patent number: 8673415Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: GrantFiled: August 9, 2011Date of Patent: March 18, 2014Assignee: Innovia Films LimitedInventors: Alastain Hugh Servante, Gary Power, Colin Marshall
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Patent number: 8663760Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: GrantFiled: February 17, 2011Date of Patent: March 4, 2014Assignee: Innovia Films LimitedInventors: Alastair Hugh Servante, Gary Power, Colin Marshall
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Publication number: 20130315992Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.Type: ApplicationFiled: August 15, 2011Publication date: November 28, 2013Inventors: Scott Clunas, John Mervyn David Storey, James Peter Sinclair, Thomas Craven Baddeley, Ahtsham Ishaq, Michael Simpson, Craig Williamson, Barry Alan Wood, Claude Michel Wischik, Charles Robert Harrington, Janet Elizabeth Rickard, David Horsley, Yin Sze Loh, Colin Marshall, Karrar Ahmad Khan
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Publication number: 20130247926Abstract: The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, wherein the composite filaments are entangled or wherein the two further comprises one or more further thermoplastic materials or wherein the weight ration of cellulose to cellulose acetate in the tow is from 10:90 to 90:10, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibres or films, and converting the fibres or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.Type: ApplicationFiled: May 17, 2013Publication date: September 26, 2013Applicant: INNOVIA FILMS LIMITEDInventors: Colin Marshall, Jamie Moffat
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Publication number: 20130192489Abstract: The present invention provides a process for producing a cellulose film in which a) cellulose is at least partly dissolved at a temperature of about 100° C. or lower in a dope comprising an ionic liquid and a cosolvent to form a cellulose solution, wherein said cosolvent comprises a polar aprotic component, and B) cellulose film is cast from the cellulose solution.Type: ApplicationFiled: June 21, 2011Publication date: August 1, 2013Applicant: INNOVIA FILMS LIMITEDInventors: Martin Cockcroft, Colin Marshall
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Publication number: 20130154139Abstract: The present invention provides a process for producing cellulose shaped articles in which a) cellulose is at least partly dissolved at a temperature of about 100° C. or lower in a dope comprising an ionic liquid and a cosolvent to form a cellulose solution, wherein said cosolvent comprises a polar aprotic component, and b) cellulose shaped articles are cast from the cellulose solution.Type: ApplicationFiled: June 21, 2011Publication date: June 20, 2013Applicant: Innovia Films LimitedInventors: Martin Cockcroft, Colin Marshall
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Patent number: 8464728Abstract: The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibers or films, and converting the fibers or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.Type: GrantFiled: September 29, 2010Date of Patent: June 18, 2013Assignee: Innovia Films LimitedInventors: Colin Marshall, Jamie Moffat
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Patent number: 8440821Abstract: Described is a method for the synthesis and/or purification of a high purity diaminophenothiazinium compound of the following formula: characterized by a purity of greater than 98% and less than 1% Azure B, 0.15% Azure A, 0.15% Azure C and 0.05% Methylene Violet Bernthsen (MVB), as impurities. Also described are related high purity compounds, compositions, and methods of using such compounds and compositions. The compounds and compositions are useful in the treatment of diseases caused by tau aggregation, such as Alzheimer's disease and other dementias, and infection.Type: GrantFiled: May 31, 2011Date of Patent: May 14, 2013Assignee: Wista Laboratories Ltd.Inventors: Claude Michel Wischik, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley
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Patent number: 8256434Abstract: The present invention concerns an at least partially transparent cigarette filter tipping film comprising a biodegradable substrate, and softener in an amount of less than 25% by weight of the biodegradable substrate, and a cigarette filter comprising a filtration material encased in a cylinder of the said tipping film.Type: GrantFiled: August 11, 2010Date of Patent: September 4, 2012Assignee: Innovia Films LimitedInventors: Paul Watters, Colin Marshall
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Publication number: 20120199147Abstract: The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibres or films, and converting the fibres or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.Type: ApplicationFiled: September 17, 2010Publication date: August 9, 2012Applicant: INNOVIA FILMS LIMIITEDInventors: Colin Marshall, Jamie Moffat
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Publication number: 20120202398Abstract: The present invention concerns a biodegradable fibre comprising composite filaments of cellulose and cellulose acetate, and a process for making such a fibre comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibres. The invention also concerns materials made from such a fibre, and garments or soft furnishings made from such a material.Type: ApplicationFiled: October 21, 2010Publication date: August 9, 2012Applicant: INNOVIA FILMS LIMITEDInventors: Colin Marshall, Jamie Moffat
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Publication number: 20120192883Abstract: The present invention concerns an at least partially transparent cigarette filter tipping film comprising a biodegradable substrate, and softener in an amount of less than 25% by weight of the biodegradable substrate, and a cigarette filter comprising a filtration material encased in a cylinder of the said tipping film.Type: ApplicationFiled: August 5, 2010Publication date: August 2, 2012Applicant: INNOVIA FILMS LIMITEDInventors: Paul Watters, Colin Marshall
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Publication number: 20120135650Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.Type: ApplicationFiled: August 9, 2011Publication date: May 31, 2012Applicant: INNOVIA FILMS LIMITEDInventors: Alastain Hugh SERVANTE, Gary Power, Colin Marshall
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Publication number: 20120058995Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the e//i method comprises the steps of in order: a thiosulfonic acid formation (TSAF) as illustrated below, wherein the reaction is carried out in the presence of a thio sulfate and an oxidizing agent that is or comprises persulfate an oxidative coupling (OC); and a ring closure (RC). The resulting compounds and compositions comprising them (e.g., tablets, capsules) are useful in methods of medical treatment and diagnosis, etc., for example, tauopathies, or Alzheimer's disease (AD).Type: ApplicationFiled: May 11, 2010Publication date: March 8, 2012Applicant: WisTa Laboratories Ltd.Inventors: Christopher Paul Larch, John Mervyn David Storey, Craig Williamson, Colin Marshall, Steven John Kemp
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Publication number: 20110294795Abstract: Described are compositions and methods of making high purity diaminophenothiazinium compounds of the following formula which are characterised by: a purity of greater than 98%; less than 1% Azure B as impurity; less than 0.15% Azure A as impurity; less than 0.15% Azure C as impurity; and less than 0.05% Methylene Violet Bernthsen (MVB) as impurity. Examples include methylthioninium chloride (MTC), also known as Methylene Blue (MB).Type: ApplicationFiled: May 31, 2011Publication date: December 1, 2011Inventors: Claude Michel WISCHIK, John Mervyn David Storey, Colin Marshall, James Peter Sinclair, Thomas Craven Baddeley